chr2:201,090,426–201,091,071

chr2 : 201,090,426 – 201,091,071

645 bp 68 TFs 11 linked genes

This 645 bp open chromatin element is linked to 11 target genes and is bound by 68 transcription factors.

Linked Genes

11 genes

Gene	Expression	Dist. to TSS	Distance	Link type
NDUFB3		18.8 kb	Distal	Multiome
HYCC2		19.1 kb	Distal	Multiome
CFLAR		25.6 kb	Distal	Multiome
CASP10		92.3 kb	Distal	Multiome
ORC2		127.1 kb	Distal	Multiome
ENSG00000183308		127.5 kb	Distal	Multiome
CASP8		142.7 kb	Distal	Multiome
NIF3L1		201.4 kb	Distal	Multiome
PPIL3		201.5 kb	Distal	Multiome
CLK1		226.1 kb	Distal	Multiome
BZW1		278.9 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

68 transcription factors

ChIP H-1_DE GSE126661.BRD3.H-1_DE 128 bp overlap

ChIP HUVEC-C_modETS1 GSE93030.BRD4.HUVEC-C_modETS1 237 bp overlap

Cebpa 1 dataset

ChIP BLaER1 ENCFF335XTP 274 bp overlap

Motif DE_72h DE_72h-Crx_MA0467.3 6 bp overlap

EOMES 4 datasets

Motif DE_48h DE_48h-EOMES_MA0800.2 9 bp overlap

Motif DE_60h DE_60h-EOMES_MA0800.2 9 bp overlap

Motif DE_72h DE_72h-EOMES_MA0800.2 9 bp overlap

ChIP hESC GSE26097.EOMES.hESC 376 bp overlap

FEZF2 3 datasets

Motif DE_48h DE_48h-FEZF2_MA2341.1 8 bp overlap

Motif DE_60h DE_60h-FEZF2_MA2341.1 8 bp overlap

Motif DE_72h DE_72h-FEZF2_MA2341.1 8 bp overlap

FOSL2 1 dataset

Motif DE_72h DE_72h-FOSL2_MA0478.2 10 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 574 bp overlap

ChIP DE DE-FOXA2-2 645 bp overlap

GATA1 3 datasets

Motif DE_48h DE_48h-GATA1_MA0035.5 7 bp overlap

Motif DE_60h DE_60h-GATA1_MA0035.5 7 bp overlap

Motif DE_72h DE_72h-GATA1_MA0035.5 7 bp overlap

GATA2 1 dataset

ChIP ME-1_CBFB-MYH11-KD GSE117138.GATA2.ME-1_CBFB-MYH11-KD 81 bp overlap

GATA4 5 datasets

ChIP BJ1-hTERT_FOXA2_GATA4_Coexp GSE92491.GATA4.BJ1-hTERT_FOXA2_GATA4_Coexp 205 bp overlap

ChIP DE DE-GATA4-1 645 bp overlap

ChIP DE DE-GATA4-2 645 bp overlap

ChIP foregut GSE117136.GATA4.foregut 300 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 256 bp overlap

GATA6 9 datasets

ChIP DE DE-GATA6-1 606 bp overlap

ChIP DE DE-GATA6-2 645 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 584 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 552 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 478 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 645 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 562 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 478 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 542 bp overlap

Motif DE_72h DE_72h-GSC_MA0648.2 6 bp overlap

Motif DE_72h DE_72h-GSC2_MA0891.2 6 bp overlap

Motif DE_72h DE_72h-Gli1_MA1990.2 10 bp overlap

Motif DE_72h DE_72h-Gli2_MA0734.4 9 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 437 bp overlap

MAFK 3 datasets

ChIP A549 ENCFF371EPR 381 bp overlap

ChIP Hep-G2 ENCSR000EDZ.MAFK.Hep-G2 167 bp overlap

ChIP HepG2 ENCFF743ZOF 241 bp overlap

Motif DE_48h DE_48h-MGA_MA0801.1 8 bp overlap

Motif DE_60h DE_60h-MGA_MA0801.1 8 bp overlap

Motif DE_72h DE_72h-MGA_MA0801.1 8 bp overlap

ChIP Hep-G2 ENCSR398TMP.MYNN.Hep-G2 105 bp overlap

NEUROD1 1 dataset

ChIP D283-Med GSE92582.NEUROD1.D283-Med 378 bp overlap

NFAT5 1 dataset

ChIP Hep-G2 ENCSR565BVI.NFAT5.Hep-G2 124 bp overlap

NR2C1 1 dataset

Motif DE_72h DE_72h-NR2C1_MA1535.2 6 bp overlap

NR2C2 2 datasets

Motif DE_72h DE_72h-NR2C2_MA0504.2 14 bp overlap

Motif DE_72h DE_72h-NR2C2_MA1536.2 6 bp overlap

NR6A1 1 dataset

Motif DE_72h DE_72h-NR6A1_MA1541.2 14 bp overlap

Nr1H2 1 dataset

Motif DE_72h DE_72h-Nr1H2_MA1996.2 6 bp overlap

Nr1H4 1 dataset

Motif DE_72h DE_72h-Nr1H4_MA1110.3 6 bp overlap

Nr1h3 1 dataset

Motif DE_72h DE_72h-Nr1h3_MA2337.1 6 bp overlap

Motif DE_72h DE_72h-OTX1_MA0711.2 6 bp overlap

PITX1 1 dataset

Motif DE_72h DE_72h-PITX1_MA0682.3 6 bp overlap

PITX3 1 dataset

Motif DE_72h DE_72h-PITX3_MA0714.2 6 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 89 bp overlap

PRDM9 1 dataset

Motif DE_72h DE_72h-PRDM9_MA1723.2 20 bp overlap

RHOXF1 1 dataset

Motif DE_72h DE_72h-RHOXF1_MA0719.2 6 bp overlap

Rarg 3 datasets

Motif DE_48h DE_48h-Rarg_MA0859.2 15 bp overlap

Motif DE_60h DE_60h-Rarg_MA0859.2 15 bp overlap

Motif DE_72h DE_72h-Rarg_MA0859.2 15 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 571 bp overlap

ChIP HUVEC-C_TGFB1 GSE134556.SMAD2-3.HUVEC-C_TGFB1 107 bp overlap

ChIP HUVEC-C_TGFB1 GSE134556.SMAD2-3.HUVEC-C_TGFB1 120 bp overlap

SMAD2_3 2 datasets

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 594 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 567 bp overlap

SMAD3 1 dataset

ChIP endoderm GSE29422.SMAD3.endoderm 182 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 421 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 569 bp overlap

Motif DE_72h DE_72h-SP5_MA1965.2 6 bp overlap

Motif DE_72h DE_72h-SP5_MA1965.2 6 bp overlap

Motif DE_72h DE_72h-SP5_MA1965.2 6 bp overlap

TBR1 3 datasets

Motif DE_48h DE_48h-TBR1_MA0802.2 9 bp overlap

Motif DE_60h DE_60h-TBR1_MA0802.2 9 bp overlap

Motif DE_72h DE_72h-TBR1_MA0802.2 9 bp overlap

TBX1 3 datasets

Motif DE_48h DE_48h-TBX1_MA0805.1 8 bp overlap

Motif DE_60h DE_60h-TBX1_MA0805.1 8 bp overlap

Motif DE_72h DE_72h-TBX1_MA0805.1 8 bp overlap

TBX15 3 datasets

Motif DE_48h DE_48h-TBX15_MA0803.1 8 bp overlap

Motif DE_60h DE_60h-TBX15_MA0803.1 8 bp overlap

Motif DE_72h DE_72h-TBX15_MA0803.1 8 bp overlap

TBX18 4 datasets

Motif DE_48h DE_48h-TBX18_MA1565.2 9 bp overlap

Motif DE_60h DE_60h-TBX18_MA1565.2 9 bp overlap

Motif DE_72h DE_72h-TBX18_MA1565.2 9 bp overlap

Motif DE_72h DE_72h-TBX18_MA1565.2 9 bp overlap

TBX2 3 datasets

Motif DE_48h DE_48h-TBX2_MA0688.2 9 bp overlap

Motif DE_60h DE_60h-TBX2_MA0688.2 9 bp overlap

Motif DE_72h DE_72h-TBX2_MA0688.2 9 bp overlap

TBX20 3 datasets

Motif DE_48h DE_48h-TBX20_MA0689.1 11 bp overlap

Motif DE_60h DE_60h-TBX20_MA0689.1 11 bp overlap

Motif DE_72h DE_72h-TBX20_MA0689.1 11 bp overlap

TBX21 3 datasets

Motif DE_48h DE_48h-TBX21_MA0690.3 10 bp overlap

Motif DE_60h DE_60h-TBX21_MA0690.3 10 bp overlap

Motif DE_72h DE_72h-TBX21_MA0690.3 10 bp overlap

TBX3 3 datasets

Motif DE_48h DE_48h-TBX3_MA1566.3 9 bp overlap

Motif DE_60h DE_60h-TBX3_MA1566.3 9 bp overlap

Motif DE_72h DE_72h-TBX3_MA1566.3 9 bp overlap

TBX4 3 datasets

Motif DE_48h DE_48h-TBX4_MA0806.1 8 bp overlap

Motif DE_60h DE_60h-TBX4_MA0806.1 8 bp overlap

Motif DE_72h DE_72h-TBX4_MA0806.1 8 bp overlap

TBX5 3 datasets

Motif DE_48h DE_48h-TBX5_MA0807.1 8 bp overlap

Motif DE_60h DE_60h-TBX5_MA0807.1 8 bp overlap

Motif DE_72h DE_72h-TBX5_MA0807.1 8 bp overlap

Motif DE_72h DE_72h-THRB_MA1574.2 13 bp overlap

Tbx6 3 datasets

Motif DE_48h DE_48h-Tbx6_MA1567.3 9 bp overlap

Motif DE_60h DE_60h-Tbx6_MA1567.3 9 bp overlap

Motif DE_72h DE_72h-Tbx6_MA1567.3 9 bp overlap

Motif DE_72h DE_72h-Wt1_MA1627.2 10 bp overlap

ChIP MCF-7 GSE102616.ZFX.MCF-7 107 bp overlap

ZMYM3 1 dataset

ChIP HepG2 ENCFF408KTI 67 bp overlap

ZNF135 2 datasets

Motif DE_72h DE_72h-ZNF135_MA1587.1 14 bp overlap

Motif DE_72h DE_72h-ZNF135_MA1587.1 14 bp overlap

ZNF213 1 dataset

Motif DE_72h DE_72h-ZNF213_MA2121.1 12 bp overlap

ZNF232 1 dataset

ChIP Hep-G2 ENCSR837GLU.ZNF232.Hep-G2 154 bp overlap

ZNF263 2 datasets

Motif DE_72h DE_72h-ZNF263_MA0528.3 7 bp overlap

ChIP Hep-G2 ENCSR313MMD.ZNF263.Hep-G2 150 bp overlap

ZNF324 3 datasets

Motif DE_48h DE_48h-ZNF324_MA1977.2 14 bp overlap

Motif DE_60h DE_60h-ZNF324_MA1977.2 14 bp overlap

Motif DE_72h DE_72h-ZNF324_MA1977.2 14 bp overlap

ZNF460 2 datasets

Motif DE_72h DE_72h-ZNF460_MA1596.1 16 bp overlap

Motif DE_72h DE_72h-ZNF460_MA1596.1 16 bp overlap

ZNF501 1 dataset

ChIP Hep-G2 ENCSR227PHM.ZNF501.Hep-G2 276 bp overlap

ZNF572 1 dataset

ChIP Hep-G2 ENCSR663CTC.ZNF572.Hep-G2 97 bp overlap

ZNF708 1 dataset

Motif DE_72h DE_72h-ZNF708_MA1730.2 9 bp overlap

ZNF770 2 datasets

Motif DE_72h DE_72h-ZNF770_MA2099.1 8 bp overlap

ChIP HepG2 ENCFF233UVH 50 bp overlap

ZNF891 1 dataset

ChIP Hep-G2 ENCSR020CLV.ZNF891.Hep-G2 79 bp overlap

Motif DE_72h DE_72h-Zfx_MA0146.3 10 bp overlap