This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
Transcription factors with Perturb-seq knockdown data for CASP10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CASP10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CASP10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:200,888,532–200,889,950 | 293.8 kb | Distal (>10kb) Multiome | 1108 | |
| chr2:200,962,915–200,964,242 | 219.5 kb | Distal (>10kb) Multiome HiCAR | 1021 | |
| chr2:201,071,202–201,072,338 | 111.3 kb | Distal (>10kb) Multiome | 993 | |
| chr2:201,090,426–201,091,071 | 92.3 kb | Distal (>10kb) Multiome | 68 | |
| chr2:201,116,279–201,117,190 | 66.5 kb | Distal (>10kb) Multiome | 907 | |
| chr2:201,125,205–201,126,756 | 56.7 kb | Distal (>10kb) Multiome | 696 | |
| chr2:201,157,926–201,158,657 | 24.7 kb | Distal (>10kb) Multiome | 540 | |
| chr2:201,177,411–201,177,648 | 5.5 kb | Proximal (<10kb) | 252 | |
| chr2:201,182,711–201,183,380 | 88 bp | At TSS Multiome | 624 | |
| chr2:201,450,975–201,452,588 | 268.6 kb | Distal (>10kb) Multiome | 1008 |
Genomic view of the CASP10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.