The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for NFAT5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NFAT5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NFAT5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:69,310,637–69,312,153 | 254.7 kb | Distal (>10kb) Multiome | 963 | |
| chr16:69,329,919–69,331,310 | 235.3 kb | Distal (>10kb) Multiome | 977 | |
| chr16:69,339,182–69,340,174 | 226.4 kb | Distal (>10kb) Multiome | 1014 | |
| chr16:69,385,555–69,386,170 | 180.0 kb | Distal (>10kb) Multiome | 857 | |
| chr16:69,424,128–69,425,019 | 141.5 kb | Distal (>10kb) Multiome | 907 | |
| chr16:69,529,449–69,529,941 | 36.2 kb | Distal (>10kb) Multiome | 450 | |
| chr16:69,565,464–69,566,984 | 149 bp | At TSS Multiome | 1044 | |
| chr16:69,726,315–69,727,097 | 160.6 kb | Distal (>10kb) Multiome | 879 | |
| chr16:69,754,401–69,755,306 | 189.0 kb | Distal (>10kb) Multiome | 922 | |
| chr16:69,762,035–69,762,848 | 196.4 kb | Distal (>10kb) Multiome | 847 |
Genomic view of the NFAT5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.