Enables RNA binding activity and cadherin binding activity. Involved in regulation of translational initiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for BZW1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BZW1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BZW1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:199,955,094–199,956,570 | 856.3 kb | Distal (>10kb) Multiome HiCAR | 1078 | |
| chr2:200,525,770–200,526,701 | 285.8 kb | Distal (>10kb) Multiome | 869 | |
| chr2:200,585,716–200,586,842 | 225.8 kb | Distal (>10kb) Multiome | 627 | |
| chr2:200,648,397–200,649,297 | 163.1 kb | Distal (>10kb) Multiome | 229 | |
| chr2:200,713,048–200,713,472 | 98.6 kb | Distal (>10kb) Multiome | 763 | |
| chr2:200,736,302–200,737,549 | 74.9 kb | Distal (>10kb) Multiome | 210 | |
| chr2:200,810,854–200,812,782 | 328 bp | At TSS Multiome | 1048 | |
| chr2:200,863,766–200,865,261 | 52.7 kb | Distal (>10kb) Multiome | 1111 | |
| chr2:200,888,532–200,889,950 | 77.4 kb | Distal (>10kb) Multiome | 1108 | |
| chr2:200,962,915–200,964,242 | 151.7 kb | Distal (>10kb) Multiome | 1021 | |
| chr2:201,071,202–201,072,338 | 259.9 kb | Distal (>10kb) Multiome | 993 | |
| chr2:201,090,426–201,091,071 | 278.9 kb | Distal (>10kb) Multiome | 68 |
Genomic view of the BZW1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.