Predicted to be involved in phosphatidylinositol phosphate biosynthetic process and protein localization to plasma membrane. Predicted to be located in cytosol and membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for HYCC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HYCC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HYCC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:200,810,854–200,812,782 | 260.1 kb | Distal (>10kb) Multiome | 1048 | |
| chr2:200,863,766–200,865,261 | 207.0 kb | Distal (>10kb) Multiome | 1111 | |
| chr2:200,888,532–200,889,950 | 182.3 kb | Distal (>10kb) Multiome | 1108 | |
| chr2:200,962,915–200,964,242 | 108.0 kb | Distal (>10kb) Multiome | 1021 | |
| chr2:201,071,202–201,072,338 | 162 bp | At TSS Multiome | 993 | |
| chr2:201,090,426–201,091,071 | 19.1 kb | Distal (>10kb) Multiome | 68 | |
| chr2:201,116,279–201,117,190 | 45.0 kb | Distal (>10kb) Multiome | 907 | |
| chr2:201,118,264–201,119,153 | 47.1 kb | Distal (>10kb) Multiome | 863 | |
| chr2:201,125,205–201,126,756 | 54.7 kb | Distal (>10kb) Multiome | 696 | |
| chr2:201,157,926–201,158,657 | 86.7 kb | Distal (>10kb) Multiome | 540 | |
| chr2:201,182,711–201,183,380 | 111.4 kb | Distal (>10kb) Multiome | 624 |
Genomic view of the HYCC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.