TFs regulating ENSG00000183308 0 TFs

Transcription factors with Perturb-seq knockdown data for ENSG00000183308. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000183308 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ENSG00000183308

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000183308, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr2:200,713,048–200,713,472	250.0 kb	Distal (>10kb) Multiome	763
chr2:200,736,302–200,737,549	226.3 kb	Distal (>10kb) Multiome	210
chr2:200,810,854–200,812,782	151.7 kb	Distal (>10kb) Multiome	1048
chr2:200,863,766–200,865,261	98.6 kb	Distal (>10kb) Multiome	1111
chr2:200,888,532–200,889,950	74.0 kb	Distal (>10kb) Multiome	1108
chr2:200,962,915–200,964,242	329 bp	At TSS Multiome	1021
chr2:201,071,202–201,072,338	108.5 kb	Distal (>10kb) Multiome	993
chr2:201,090,426–201,091,071	127.5 kb	Distal (>10kb) Multiome	68
chr2:201,116,279–201,117,190	153.4 kb	Distal (>10kb) Multiome	907
chr2:201,118,264–201,119,153	155.4 kb	Distal (>10kb) Multiome	863
chr2:201,125,205–201,126,756	163.1 kb	Distal (>10kb) Multiome	696
chr2:201,157,926–201,158,657	195.1 kb	Distal (>10kb) Multiome HiCAR	540
chr2:201,182,711–201,183,380	219.7 kb	Distal (>10kb) Multiome HiCAR	624

Genome Browser

Genomic view of the ENSG00000183308 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.