chr19:47,196,586–47,197,452

chr19 : 47,196,586 – 47,197,452

866 bp 94 TFs 13 linked genes

This 866 bp open chromatin element is linked to 13 target genes and is bound by 94 transcription factors.

Linked Genes

13 genes

Gene	Expression	Dist. to TSS	Distance	Link type
BBC3		35.9 kb	Distal	Multiome
CCDC9		59.7 kb	Distal	Multiome
SAE1		66.0 kb	Distal	Multiome
INAFM1		78.0 kb	Distal	Multiome
ZC3H4		84.6 kb	Distal	Multiome
C5AR1		113.0 kb	Distal	Multiome
TMEM160		148.2 kb	Distal	Multiome
DHX34		152.5 kb	Distal	Multiome
ENSG00000288827		152.5 kb	Distal	Multiome
NPAS1		161.5 kb	Distal	Multiome
MEIS3		222.5 kb	Distal	Multiome
SLC8A2		250.8 kb	Distal	Multiome
KPTN		287.4 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

94 transcription factors

Motif DE_72h DE_72h-ALX3_MA0634.2 6 bp overlap

ChIP breast-cancer_ENOB-2854 GSE128018.AR.breast-cancer_ENOB-2854 138 bp overlap

ChIP RCC4 GSE85352.ARNT.RCC4 111 bp overlap

ASCL1 1 dataset

ChIP NCI-H889 GSE69394.ASCL1.NCI-H889 156 bp overlap

Cebpa 3 datasets

ChIP BLaER1 ENCFF031ISE 255 bp overlap

ChIP BLaER1 ENCFF274GAT 248 bp overlap

ChIP BLaER1 ENCFF335XTP 369 bp overlap

Motif DE_72h DE_72h-DRGX_MA1481.2 6 bp overlap

ChIP K562 ENCFF511ZZZ 474 bp overlap

Motif DE_72h DE_72h-EMX1_MA0612.3 6 bp overlap

Motif DE_72h DE_72h-EMX2_MA0886.2 6 bp overlap

Motif DE_72h DE_72h-EN1_MA0027.3 6 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 271 bp overlap

ESR1_pS118 1 dataset

ChIP MCF-7_E2_sc GSE117569.ESR1_pS118.MCF-7_E2_sc 94 bp overlap

ETV2::DRGX 1 dataset

Motif DE_72h DE_72h-ETV2DRGX_MA1940.2 12 bp overlap

ETV5::DRGX 1 dataset

Motif DE_72h DE_72h-ETV5DRGX_MA1944.2 12 bp overlap

Motif DE_72h DE_72h-EVX1_MA0887.2 6 bp overlap

Motif DE_72h DE_72h-EVX2_MA0888.2 6 bp overlap

FOXA1 1 dataset

ChIP LNCaP-abl GSE63034.FOXA1.LNCaP-abl 163 bp overlap

FOXA2 4 datasets

ChIP DE DE-FOXA2-1 498 bp overlap

ChIP DE DE-FOXA2-1 163 bp overlap

ChIP DE DE-FOXA2-2 492 bp overlap

ChIP DE DE-FOXA2-2 246 bp overlap

FOXE1 1 dataset

Motif DE_72h DE_72h-FOXE1_MA1487.3 12 bp overlap

FOXL2 1 dataset

ChIP HGrC1_C134W-TGF GSE138496.FOXL2.HGrC1_C134W-TGF 149 bp overlap

GATA4 3 datasets

ChIP BJ1-hTERT_FOXA2_GATA4_Coexp GSE92491.GATA4.BJ1-hTERT_FOXA2_GATA4_Coexp 218 bp overlap

ChIP DE DE-GATA4-1 843 bp overlap

ChIP DE DE-GATA4-2 866 bp overlap

GATA6 8 datasets

ChIP DE DE-GATA6-1 423 bp overlap

ChIP DE DE-GATA6-1 156 bp overlap

ChIP DE DE-GATA6-2 866 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 298 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 389 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 450 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 347 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 360 bp overlap

Motif DE_72h DE_72h-GSX1_MA0892.2 6 bp overlap

HOXA1 1 dataset

Motif DE_72h DE_72h-HOXA1_MA1495.2 6 bp overlap

HOXA2 1 dataset

Motif DE_72h DE_72h-HOXA2_MA0900.3 6 bp overlap

HOXB2 1 dataset

Motif DE_72h DE_72h-HOXB2_MA0902.3 6 bp overlap

HOXB3 1 dataset

Motif DE_72h DE_72h-HOXB3_MA0903.2 6 bp overlap

HOXB5 1 dataset

Motif DE_72h DE_72h-HOXB5_MA0904.3 6 bp overlap

HOXC8 1 dataset

Motif DE_72h DE_72h-HOXC8_MA1505.2 6 bp overlap

Motif DE_72h DE_72h-Hmx1_MA0896.2 9 bp overlap

Motif DE_72h DE_72h-Hmx3_MA0898.2 9 bp overlap

IKZF2 1 dataset

Motif DE_72h DE_72h-IKZF2_MA2326.1 6 bp overlap

Motif DE_72h DE_72h-ISX_MA0654.2 6 bp overlap

Ikzf3 1 dataset

Motif DE_72h DE_72h-Ikzf3_MA1992.2 9 bp overlap

Motif DE_72h DE_72h-Lhx4_MA0704.2 6 bp overlap

Motif DE_72h DE_72h-Lhx8_MA0705.2 6 bp overlap

Motif DE_48h DE_48h-MAF_MA1520.2 13 bp overlap

Motif DE_72h DE_72h-MAF_MA1520.2 13 bp overlap

MAFA 2 datasets

Motif DE_48h DE_48h-MAFA_MA1521.2 13 bp overlap

Motif DE_72h DE_72h-MAFA_MA1521.2 13 bp overlap

ChIP islet ERP004003.MAFB.islet 270 bp overlap

MAFF 6 datasets

Motif DE_72h DE_72h-MAFF_MA0495.4 11 bp overlap

ChIP HeLa-S3 ENCFF783SBT 277 bp overlap

ChIP HeLa-S3 ENCSR140DSL.MAFF.HeLa-S3 153 bp overlap

ChIP HepG2 ENCFF452YUT 277 bp overlap

ChIP K-562 ENCSR000EGI.MAFF.K-562 193 bp overlap

ChIP K562 ENCFF071YKK 281 bp overlap

MAFK 9 datasets

ChIP A549 ENCFF371EPR 297 bp overlap

ChIP H1 ENCFF854XWE 285 bp overlap

ChIP Hep-G2 ENCSR000EDZ.MAFK.Hep-G2 180 bp overlap

ChIP HepG2 ENCFF743ZOF 123 bp overlap

ChIP HepG2 ENCFF767LDG 257 bp overlap

ChIP IMR-90 ENCFF336DHZ 271 bp overlap

ChIP K-562 ENCSR000EGX.MAFK.K-562 153 bp overlap

ChIP K562 ENCFF380WHM 281 bp overlap

ChIP WA01 ENCSR000EBS.MAFK.WA01 123 bp overlap

MEIS1 4 datasets

Motif DE_48h DE_48h-MEIS1_MA0498.3 5 bp overlap

Motif DE_48h DE_48h-MEIS1_MA0498.3 5 bp overlap

Motif DE_72h DE_72h-MEIS1_MA0498.3 5 bp overlap

Motif DE_72h DE_72h-MEIS1_MA0498.3 5 bp overlap

MEIS2 2 datasets

Motif DE_48h DE_48h-MEIS2_MA0774.1 8 bp overlap

Motif DE_72h DE_72h-MEIS2_MA0774.1 8 bp overlap

MIXL1 1 dataset

Motif DE_72h DE_72h-MIXL1_MA0662.2 6 bp overlap

Motif DE_72h DE_72h-MNX1_MA0707.3 6 bp overlap

Mafg 2 datasets

Motif DE_48h DE_48h-Mafg_MA0659.4 12 bp overlap

Motif DE_72h DE_72h-Mafg_MA0659.4 12 bp overlap

NKX3-1 1 dataset

ChIP islet ERP004003.NKX3-1.islet 215 bp overlap

NKX6-2 1 dataset

Motif DE_72h DE_72h-NKX6-2_MA0675.2 6 bp overlap

NR1D1 1 dataset

Motif DE_72h DE_72h-NR1D1_MA1531.2 14 bp overlap

NR2C1 1 dataset

Motif DE_72h DE_72h-NR2C1_MA1535.2 6 bp overlap

NR2C2 1 dataset

Motif DE_72h DE_72h-NR2C2_MA1536.2 6 bp overlap

NR2F1 1 dataset

Motif DE_72h DE_72h-NR2F1_MA0017.3 12 bp overlap

NR2F2 1 dataset

ChIP MCF-7_E2 GSE132432.NR2F2.MCF-7_E2 594 bp overlap

Nr1H2 1 dataset

Motif DE_72h DE_72h-Nr1H2_MA1996.2 6 bp overlap

Nr1H4 1 dataset

Motif DE_72h DE_72h-Nr1H4_MA1110.3 6 bp overlap

Nr1h3 1 dataset

Motif DE_72h DE_72h-Nr1h3_MA2337.1 6 bp overlap

Nr2F6 1 dataset

Motif DE_72h DE_72h-Nr2F6_MA0728.1 15 bp overlap

Motif DE_72h DE_72h-PDX1_MA0132.3 6 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 493 bp overlap

POU6F1 1 dataset

Motif DE_72h DE_72h-POU6F1_MA0628.2 6 bp overlap

PRRX1 1 dataset

Motif DE_72h DE_72h-PRRX1_MA0716.2 6 bp overlap

Motif DE_72h DE_72h-RAX2_MA0717.2 6 bp overlap

Motif DE_72h DE_72h-Rarb_MA0857.1 16 bp overlap

Motif DE_72h DE_72h-Rarg_MA0859.2 15 bp overlap

Motif DE_72h DE_72h-SHOX_MA0630.2 6 bp overlap

SMAD2 2 datasets

ChIP endoderm GSE29422.SMAD2.endoderm 228 bp overlap

ChIP endoderm GSE29422.SMAD2.endoderm 156 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 866 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 798 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 429 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 449 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 725 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 461 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 634 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 714 bp overlap

SMAD3 1 dataset

ChIP endoderm GSE29422.SMAD3.endoderm 220 bp overlap

SMAD4 1 dataset

ChIP endoderm GSE29422.SMAD4.endoderm 269 bp overlap

SMARCC1 2 datasets

ChIP DE_D1 S15-DE-d1-BAF155-exp1 243 bp overlap

ChIP TTC-549_NoDox GSE71504.SMARCC1.TTC-549_NoDox 158 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 404 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 865 bp overlap

SOX18 1 dataset

Motif DE_72h DE_72h-SOX18_MA1563.2 8 bp overlap

Motif DE_72h DE_72h-SP2_MA0516.3 9 bp overlap

Motif DE_72h DE_72h-SRY_MA0084.2 7 bp overlap

SUPT5H 1 dataset

ChIP HCT-116_pThr806 GSE138548.SUPT5H.HCT-116_pThr806 104 bp overlap

Shox2 1 dataset

Motif DE_72h DE_72h-Shox2_MA0720.2 6 bp overlap

Six3 2 datasets

Motif DE_48h DE_48h-Six3_MA0631.2 11 bp overlap

Motif DE_72h DE_72h-Six3_MA0631.2 11 bp overlap

Stat6 1 dataset

Motif DE_72h DE_72h-Stat6_MA0520.2 10 bp overlap

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 195 bp overlap

Motif DE_72h DE_72h-TBP_MA0108.3 7 bp overlap

Motif DE_72h DE_72h-TLX2_MA1577.2 6 bp overlap

TP63 4 datasets

ChIP keratinocyte_D0 GSE59824.TP63.keratinocyte_D0 206 bp overlap

ChIP keratinocyte_D2 GSE59824.TP63.keratinocyte_D2 264 bp overlap

ChIP keratinocyte_D4 GSE59824.TP63.keratinocyte_D4 235 bp overlap

ChIP keratinocyte_D7 GSE59824.TP63.keratinocyte_D7 235 bp overlap

Motif DE_72h DE_72h-UNCX_MA0721.2 6 bp overlap

Motif DE_72h DE_72h-VAX2_MA0723.3 6 bp overlap

ZNF135 1 dataset

Motif DE_72h DE_72h-ZNF135_MA1587.1 14 bp overlap

ZNF157 1 dataset

Motif DE_72h DE_72h-ZNF157_MA2331.1 21 bp overlap

ZNF316 1 dataset

ChIP K562 ENCFF838QCD 221 bp overlap

ZNF343 1 dataset

Motif DE_72h DE_72h-ZNF343_MA1711.2 16 bp overlap

ZNF35 1 dataset

Motif DE_72h DE_72h-ZNF35_MA2333.1 7 bp overlap

ZNF528 1 dataset

Motif DE_72h DE_72h-ZNF528_MA1597.1 17 bp overlap

Motif DE_72h DE_72h-Zfx_MA0146.3 10 bp overlap

mix-a 1 dataset

Motif DE_72h DE_72h-mix-a_MA0621.2 7 bp overlap