Predicted to enable calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration and calcium:sodium antiporter activity. Predicted to be involved in several processes, including learning or memory; monoatomic cation transmembrane transport; and regulation of short-term neuronal synaptic plasticity. Predicted to act upstream of or within several processes, including modulation of chemical synaptic transmission; regulation of action potential firing pattern; and response to ischemia. Located in presynapse. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SLC8A2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC8A2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC8A2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:47,157,325–47,158,494 | 290.0 kb | Distal (>10kb) Multiome | 271 | |
| chr19:47,196,586–47,197,452 | 250.8 kb | Distal (>10kb) Multiome | 94 | |
| chr19:47,225,386–47,231,990 | 219.8 kb | Distal (>10kb) Multiome | 1389 | |
| chr19:47,240,827–47,241,572 | 206.4 kb | Distal (>10kb) Multiome | 616 | |
| chr19:47,242,713–47,243,645 | 204.5 kb | Distal (>10kb) Multiome | 568 | |
| chr19:47,243,835–47,244,896 | 203.3 kb | Distal (>10kb) Multiome | 1001 | |
| chr19:47,256,041–47,258,057 | 190.5 kb | Distal (>10kb) Multiome | 907 | |
| chr19:47,272,778–47,275,890 | 174.2 kb | Distal (>10kb) Multiome | 931 | |
| chr19:47,348,695–47,349,758 | 98.4 kb | Distal (>10kb) Multiome | 766 | |
| chr19:47,406,825–47,407,408 | 40.3 kb | Distal (>10kb) Multiome | 333 | |
| chr19:47,427,132–47,428,809 | 20.4 kb | Distal (>10kb) Multiome | 506 | |
| chr19:47,429,865–47,430,531 | 17.3 kb | Distal (>10kb) Multiome | 438 | |
| chr19:47,447,043–47,448,262 | 18 bp | At TSS Multiome | 510 | |
| chr19:47,471,631–47,472,340 | 24.4 kb | Distal (>10kb) Multiome | 500 | |
| chr19:47,483,636–47,484,543 | 36.5 kb | Distal (>10kb) Multiome | 841 | |
| chr19:47,514,152–47,515,901 | 67.7 kb | Distal (>10kb) Multiome | 895 | |
| chr19:47,600,223–47,600,983 | 152.9 kb | Distal (>10kb) Multiome | 807 | |
| chr19:47,607,980–47,609,479 | 161.2 kb | Distal (>10kb) Multiome | 832 | |
| chr19:47,647,803–47,648,987 | 200.8 kb | Distal (>10kb) Multiome | 693 | |
| chr19:47,729,949–47,730,505 | 282.6 kb | Distal (>10kb) Multiome HiCAR | 425 | |
| chr19:47,743,369–47,743,911 | 296.1 kb | Distal (>10kb) Multiome HiCAR | 929 | |
| chr19:47,745,136–47,745,915 | 298.0 kb | Distal (>10kb) Multiome HiCAR | 784 |
Genomic view of the SLC8A2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.