chr18 : 47,888,213 – 47,888,747

534 bp 112 TFs 1 linked gene

This 534 bp open chromatin element is linked to SMAD2 and is bound by 112 transcription factors.

Linked Genes

1 gene

Gene	Expression	Dist. to TSS	Distance	Link type
SMAD2		42.3 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

112 transcription factors

ALX3 1 dataset

Motif DE_48h DE_48h-ALX3_MA0634.2 6 bp overlap

ARGFX 1 dataset

Motif DE_48h DE_48h-ARGFX_MA1463.2 8 bp overlap

ATF7 1 dataset

ChIP GM12878 ENCSR014YCR.ATF7.GM12878 218 bp overlap

Alx1 1 dataset

Motif DE_48h DE_48h-Alx1_MA0854.2 8 bp overlap

Alx4 1 dataset

Motif DE_48h DE_48h-Alx4_MA0853.2 12 bp overlap

Arx 1 dataset

Motif DE_48h DE_48h-Arx_MA0874.2 10 bp overlap

BHLHE40 2 datasets

ChIP GM12878 ENCFF521IZR 346 bp overlap

ChIP GM12878 ENCSR987MTA.BHLHE40.GM12878 272 bp overlap

CRX 3 datasets

ChIP retina_Hu20 GSE137311.CRX.retina_Hu20 212 bp overlap

ChIP retina_Hu3 GSE137311.CRX.retina_Hu3 265 bp overlap

ChIP retina_Hu6 GSE137311.CRX.retina_Hu6 301 bp overlap

CTCF 3 datasets

ChIP retina_Hu22 GSE137311.CTCF.retina_Hu22 333 bp overlap

ChIP retina_Hu25 GSE137311.CTCF.retina_Hu25 334 bp overlap

ChIP retina_Hu6 GSE137311.CTCF.retina_Hu6 325 bp overlap

DRGX 1 dataset

Motif DE_48h DE_48h-DRGX_MA1481.2 6 bp overlap

DUX4 1 dataset

Motif DE_48h DE_48h-DUX4_MA0468.1 11 bp overlap

DUXA 1 dataset

Motif DE_48h DE_48h-DUXA_MA0884.2 13 bp overlap

EMX1 1 dataset

Motif DE_48h DE_48h-EMX1_MA0612.3 6 bp overlap

EMX2 1 dataset

Motif DE_48h DE_48h-EMX2_MA0886.2 6 bp overlap

EN1 1 dataset

Motif DE_48h DE_48h-EN1_MA0027.3 6 bp overlap

EN2 1 dataset

Motif DE_48h DE_48h-EN2_MA0642.3 7 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 262 bp overlap

ESX1 1 dataset

Motif DE_48h DE_48h-ESX1_MA0644.3 7 bp overlap

ETS1 1 dataset

ChIP CTV-1_DSG GSE128835.ETS1.CTV-1_DSG 215 bp overlap

EVX1 1 dataset

Motif DE_48h DE_48h-EVX1_MA0887.2 6 bp overlap

EVX2 1 dataset

Motif DE_48h DE_48h-EVX2_MA0888.2 6 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 430 bp overlap

ChIP DE DE-FOXA2-2 410 bp overlap

GATA1 2 datasets

ChIP HUDEP-2_30min GSE104676.GATA1.HUDEP-2_30min 182 bp overlap

ChIP K-562 GSE107726.GATA1.K-562 286 bp overlap

GATA4 2 datasets

ChIP DE DE-GATA4-1 534 bp overlap

ChIP DE DE-GATA4-2 534 bp overlap

GATA6 9 datasets

ChIP DE DE-GATA6-1 534 bp overlap

ChIP DE DE-GATA6-2 534 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 315 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 515 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 274 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 534 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 534 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 432 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 534 bp overlap

GBX1 1 dataset

Motif DE_48h DE_48h-GBX1_MA0889.2 7 bp overlap

GLYR1 1 dataset

ChIP HeLa GSE20303.GLYR1.HeLa 309 bp overlap

GSX1 1 dataset

Motif DE_48h DE_48h-GSX1_MA0892.2 6 bp overlap

GSX2 1 dataset

Motif DE_48h DE_48h-GSX2_MA0893.3 7 bp overlap

HDAC1 1 dataset

ChIP K-562 ENCSR387UWP.HDAC1.K-562 268 bp overlap

HDAC2 1 dataset

ChIP K-562 GSE140325.HDAC2.K-562 92 bp overlap

HOXA1 1 dataset

Motif DE_48h DE_48h-HOXA1_MA1495.2 6 bp overlap

HOXA2 1 dataset

Motif DE_48h DE_48h-HOXA2_MA0900.3 6 bp overlap

HOXA3 1 dataset

Motif DE_48h DE_48h-HOXA3_MA2119.1 7 bp overlap

HOXA5 1 dataset

Motif DE_48h DE_48h-HOXA5_MA0158.2 8 bp overlap

HOXB1 1 dataset

Motif DE_48h DE_48h-HOXB1_MA2093.1 7 bp overlap

HOXB2 1 dataset

Motif DE_48h DE_48h-HOXB2_MA0902.3 6 bp overlap

HOXB3 1 dataset

Motif DE_48h DE_48h-HOXB3_MA0903.2 6 bp overlap

HOXB5 1 dataset

Motif DE_48h DE_48h-HOXB5_MA0904.3 6 bp overlap

HOXC8 1 dataset

Motif DE_48h DE_48h-HOXC8_MA1505.2 6 bp overlap

HOXD3 1 dataset

Motif DE_48h DE_48h-HOXD3_MA0912.2 8 bp overlap

HSF1 1 dataset

ChIP MO91_27A_20UM GSE45852.HSF1.MO91_27A_20UM 175 bp overlap

ISX 1 dataset

Motif DE_48h DE_48h-ISX_MA0654.2 6 bp overlap

KLF1 1 dataset

Motif DE_48h DE_48h-KLF1_MA0493.3 8 bp overlap

KLF10 1 dataset

Motif DE_48h DE_48h-KLF10_MA1511.2 9 bp overlap

KLF14 1 dataset

Motif DE_48h DE_48h-KLF14_MA0740.2 9 bp overlap

KLF2 1 dataset

Motif DE_48h DE_48h-KLF2_MA1515.2 8 bp overlap

KLF4 1 dataset

Motif DE_48h DE_48h-KLF4_MA0039.5 8 bp overlap

KLF5 1 dataset

Motif DE_48h DE_48h-KLF5_MA0599.1 10 bp overlap

KLF9 1 dataset

Motif DE_48h DE_48h-KLF9_MA1107.3 11 bp overlap

LBX1 1 dataset

Motif DE_48h DE_48h-LBX1_MA0618.2 7 bp overlap

LHX5 1 dataset

Motif DE_48h DE_48h-LHX5_MA1519.2 7 bp overlap

LHX6 1 dataset

Motif DE_48h DE_48h-LHX6_MA0658.2 8 bp overlap

LHX9 1 dataset

Motif DE_48h DE_48h-LHX9_MA0701.3 7 bp overlap

LMX1A 1 dataset

Motif DE_48h DE_48h-LMX1A_MA0702.3 7 bp overlap

LMX1B 1 dataset

Motif DE_48h DE_48h-LMX1B_MA0703.3 8 bp overlap

Lhx1 1 dataset

Motif DE_48h DE_48h-Lhx1_MA1518.3 10 bp overlap

Lhx4 1 dataset

Motif DE_48h DE_48h-Lhx4_MA0704.2 6 bp overlap

Lhx8 1 dataset

Motif DE_48h DE_48h-Lhx8_MA0705.2 6 bp overlap

MEF2D 2 datasets

ChIP retina_Hu13 GSE137311.MEF2D.retina_Hu13 204 bp overlap

ChIP retina_Hu25 GSE137311.MEF2D.retina_Hu25 264 bp overlap

MEOX1 1 dataset

Motif DE_48h DE_48h-MEOX1_MA0661.2 7 bp overlap

MEOX2 1 dataset

Motif DE_48h DE_48h-MEOX2_MA0706.2 7 bp overlap

MITF 3 datasets

ChIP 501-mel GSE61965.MITF.501-mel 183 bp overlap

ChIP K-562 ENCSR797SWM.MITF.K-562 321 bp overlap

ChIP K562 ENCFF731XJJ 392 bp overlap

MIXL1 1 dataset

Motif DE_48h DE_48h-MIXL1_MA0662.2 6 bp overlap

MNX1 1 dataset

Motif DE_48h DE_48h-MNX1_MA0707.3 6 bp overlap

MTA2 1 dataset

ChIP GM12878 ENCSR293QAR.MTA2.GM12878 286 bp overlap

NFATC3 1 dataset

ChIP GM12878 ENCSR437GBJ.NFATC3.GM12878 213 bp overlap

NKX6-2 1 dataset

Motif DE_48h DE_48h-NKX6-2_MA0675.2 6 bp overlap

NOTCH1 1 dataset

ChIP HPBALL GSE39263.NOTCH1.HPBALL 212 bp overlap

NOTO 1 dataset

Motif DE_48h DE_48h-NOTO_MA0710.2 7 bp overlap

NRL 1 dataset

ChIP retina_Hu13 GSE137311.NRL.retina_Hu13 204 bp overlap

OTX2 1 dataset

ChIP retina_Hu7 GSE137311.OTX2.retina_Hu7 277 bp overlap

PAX4 1 dataset

Motif DE_48h DE_48h-PAX4_MA0068.2 8 bp overlap

PDX1 1 dataset

Motif DE_48h DE_48h-PDX1_MA0132.3 6 bp overlap

PHOX2A 1 dataset

Motif DE_48h DE_48h-PHOX2A_MA0713.1 11 bp overlap

PHOX2B 2 datasets

ChIP CLB-Ga GSE90683.PHOX2B.CLB-Ga 252 bp overlap

Motif DE_48h DE_48h-PHOX2B_MA0681.3 12 bp overlap

POU1F1 1 dataset

Motif DE_48h DE_48h-POU1F1_MA0784.3 14 bp overlap

POU3F2 1 dataset

Motif DE_48h DE_48h-POU3F2_MA0787.1 12 bp overlap

POU6F1 1 dataset

Motif DE_48h DE_48h-POU6F1_MA0628.2 6 bp overlap

POU6F2 1 dataset

Motif DE_48h DE_48h-POU6F2_MA0793.2 9 bp overlap

PROP1 1 dataset

Motif DE_48h DE_48h-PROP1_MA0715.1 11 bp overlap

PRRX1 1 dataset

Motif DE_48h DE_48h-PRRX1_MA0716.2 6 bp overlap

PRRX2 1 dataset

Motif DE_48h DE_48h-PRRX2_MA0075.4 7 bp overlap

RAD51 2 datasets

ChIP GM12878 ENCFF916JXQ 389 bp overlap

ChIP GM12878 ENCSR482TWQ.RAD51.GM12878 352 bp overlap

RAX2 1 dataset

Motif DE_48h DE_48h-RAX2_MA0717.2 6 bp overlap

RCOR1 1 dataset

ChIP SK-N-SH ENCSR009TKN.RCOR1.SK-N-SH 155 bp overlap

RORB 1 dataset

ChIP retina_Hu22 GSE137311.RORB.retina_Hu22 255 bp overlap

SHOX 1 dataset

Motif DE_48h DE_48h-SHOX_MA0630.2 6 bp overlap

SMAD2 1 dataset

ChIP endoderm GSE29422.SMAD2.endoderm 236 bp overlap

SMAD2-3 1 dataset

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 378 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 280 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 489 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 476 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 534 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 498 bp overlap

SMAD3 1 dataset

ChIP endoderm GSE29422.SMAD3.endoderm 199 bp overlap

SMAD4 1 dataset

ChIP endoderm GSE29422.SMAD4.endoderm 249 bp overlap

SMARCA4 5 datasets

ChIP 501-mel_SHCTR GSE61965.SMARCA4.501-mel_SHCTR 222 bp overlap

ChIP CTV-1_DSG GSE128835.SMARCA4.CTV-1_DSG 350 bp overlap

ChIP CTV-1_DSG_SPI1-mut GSE128835.SMARCA4.CTV-1_DSG_SPI1-mut 309 bp overlap

ChIP CTV-1_FLAG GSE128835.SMARCA4.CTV-1_FLAG 202 bp overlap

ChIP CTV-1_delQ GSE128835.SMARCA4.CTV-1_delQ 228 bp overlap

SMARCE1 1 dataset

ChIP K-562 ENCSR157TCS.SMARCE1.K-562 241 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 128 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 453 bp overlap

SPI1 10 datasets

ChIP CTV-1_FLAG_15perc GSE128835.SPI1.CTV-1_FLAG_15perc 350 bp overlap

ChIP CTV-1_delA GSE128835.SPI1.CTV-1_delA 313 bp overlap

ChIP CTV-1_delQ GSE128835.SPI1.CTV-1_delQ 375 bp overlap

ChIP CTV-1_delQA GSE128835.SPI1.CTV-1_delQA 328 bp overlap

ChIP GM12878 ENCFF134LCP 256 bp overlap

ChIP GM12891 ENCFF563IUT 135 bp overlap

ChIP GM12891 ENCSR000BIJ.SPI1.GM12891 406 bp overlap

ChIP K-562 GSE70482.SPI1.K-562 291 bp overlap

ChIP K-562 ENCSR000BGW.SPI1.K-562 173 bp overlap

ChIP K562 ENCFF410ORC 185 bp overlap

SPIB 2 datasets

ChIP OCI-Ly3 GSE56857.SPIB.OCI-Ly3 427 bp overlap

ChIP OCI-Ly3_SHCTR GSE56857.SPIB.OCI-Ly3_SHCTR 264 bp overlap

Shox2 1 dataset

Motif DE_48h DE_48h-Shox2_MA0720.2 6 bp overlap

T 1 dataset

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 201 bp overlap

TCF12 1 dataset

ChIP SK-N-SH ENCFF147AHB 275 bp overlap

TLX2 1 dataset

Motif DE_48h DE_48h-TLX2_MA1577.2 6 bp overlap

TWIST1 6 datasets

ChIP BE2C GSE80151.TWIST1.BE2C 194 bp overlap

ChIP SHEP-21N GSE80151.TWIST1.SHEP-21N 244 bp overlap

ChIP SHEP-21N GSE80151.TWIST1.SHEP-21N 176 bp overlap

ChIP SHEP-21N_24h GSE80151.TWIST1.SHEP-21N_24h 191 bp overlap

ChIP SHEP-21N_DOX_0H GSE80151.TWIST1.SHEP-21N_DOX_0H 244 bp overlap

ChIP SK-N-BE2-C GSE80151.TWIST1.SK-N-BE2-C 194 bp overlap

UNCX 1 dataset

Motif DE_48h DE_48h-UNCX_MA0721.2 6 bp overlap

USF1 2 datasets

ChIP K-562 ENCSR000BKT.USF1.K-562 211 bp overlap

ChIP SK-N-SH ENCSR000BMF.USF1.SK-N-SH 256 bp overlap

USF2 3 datasets

ChIP GM12878 GSE97661.USF2.GM12878 260 bp overlap

ChIP K-562 ENCSR578KEN.USF2.K-562 167 bp overlap

ChIP K562 ENCFF397QGU 264 bp overlap

VAX1 1 dataset

Motif DE_48h DE_48h-VAX1_MA0722.2 7 bp overlap

VAX2 1 dataset

Motif DE_48h DE_48h-VAX2_MA0723.3 6 bp overlap

VSX1 1 dataset

Motif DE_48h DE_48h-VSX1_MA0725.2 7 bp overlap

VSX2 1 dataset

Motif DE_48h DE_48h-VSX2_MA0726.2 7 bp overlap

ZKSCAN2 1 dataset

ChIP HEK293T GSE78099.ZKSCAN2.HEK293T 189 bp overlap