chr11:61,010,497–61,011,303

chr11 : 61,010,497 – 61,011,303

806 bp 81 TFs 6 linked genes

This 806 bp open chromatin element is linked to 6 target genes and is bound by 81 transcription factors.

Linked Genes

6 genes

Gene	Expression	Dist. to TSS	Distance	Link type
CD6		2.1 kb	Proximal	Proximity
TMEM132A		86.3 kb	Distal	Multiome
TMEM109		96.6 kb	Distal	Multiome
PRPF19		104.2 kb	Distal	Multiome
VPS37C		150.6 kb	Distal	Multiome
VWCE		284.2 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

81 transcription factors

Bcl11B 2 datasets

Motif DE_60h DE_60h-Bcl11B_MA1989.2 9 bp overlap

Motif DE_72h DE_72h-Bcl11B_MA1989.2 9 bp overlap

ChIP SET-2 GSE65138.CDK8.SET-2 86 bp overlap

CREBBP 1 dataset

ChIP retina_Hu33 GSE137311.CREBBP.retina_Hu33 235 bp overlap

ChIP retina_Hu20 GSE137311.CRX.retina_Hu20 413 bp overlap

ChIP retina_Hu21 GSE137311.CRX.retina_Hu21 275 bp overlap

ChIP retina_Hu3 GSE137311.CRX.retina_Hu3 464 bp overlap

ChIP retina_Hu6 GSE137311.CRX.retina_Hu6 562 bp overlap

CTCF 3 datasets

ChIP retina_Hu22 GSE137311.CTCF.retina_Hu22 443 bp overlap

ChIP retina_Hu25 GSE137311.CTCF.retina_Hu25 431 bp overlap

ChIP retina_Hu6 GSE137311.CTCF.retina_Hu6 522 bp overlap

ChIP K-562 ENCSR219BXP.DPF2.K-562 272 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 198 bp overlap

ChIP aortic-endothelial-cell_D49 GSE139377.ERG.aortic-endothelial-cell_D49 105 bp overlap

ChIP U2OS_10nM-E2-B GSE151039.ESR1.U2OS_10nM-E2-B 62 bp overlap

EZH2 7 datasets

ChIP Hep-G2 ENCSR000ARI.EZH2.Hep-G2 529 bp overlap

ChIP dermal-fibroblast_Untransformed GSE126396.EZH2.dermal-fibroblast_Untransformed 266 bp overlap

ChIP endothelial cell of umbilical vein ENCFF539AKL 292 bp overlap

ChIP endothelial cell of umbilical vein ENCFF539AKL 491 bp overlap

ChIP endothelial cell of umbilical vein ENCFF539AKL 770 bp overlap

ChIP fibroblast of dermis ENCFF029VZK 355 bp overlap

ChIP neural progenitor cell ENCFF018MKA 426 bp overlap

EZH2_phosphoT487 1 dataset

ChIP neural_progenitor ENCSR656MXA.EZH2_phosphoT487.neural_progenitor 390 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 571 bp overlap

ChIP DE DE-FOXA2-2 521 bp overlap

GATA4 6 datasets

ChIP DE DE-GATA4-1 541 bp overlap

ChIP DE DE-GATA4-2 629 bp overlap

Motif DE_60h DE_60h-GATA4_MA0482.3 8 bp overlap

Motif DE_72h DE_72h-GATA4_MA0482.3 8 bp overlap

ChIP foregut GSE117136.GATA4.foregut 317 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 660 bp overlap

GATA6 4 datasets

ChIP DE DE-GATA6-1 532 bp overlap

ChIP DE DE-GATA6-2 625 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 473 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 442 bp overlap

GLIS1 2 datasets

ChIP HEK293 ENCFF299RSE 77 bp overlap

ChIP HEK293 ENCSR482BBZ.GLIS1.HEK293 209 bp overlap

GLIS3 1 dataset

ChIP H9_plus GSE109562.GLIS3.H9_plus 84 bp overlap

Gli1 2 datasets

Motif DE_60h DE_60h-Gli1_MA1990.2 10 bp overlap

Motif DE_72h DE_72h-Gli1_MA1990.2 10 bp overlap

HIVEP1 1 dataset

ChIP Hep-G2 ENCSR697WMX.HIVEP1.Hep-G2 322 bp overlap

HOXB4 2 datasets

Motif DE_60h DE_60h-HOXB4_MA1499.2 6 bp overlap

Motif DE_72h DE_72h-HOXB4_MA1499.2 6 bp overlap

HOXC4 2 datasets

Motif DE_60h DE_60h-HOXC4_MA1504.2 6 bp overlap

Motif DE_72h DE_72h-HOXC4_MA1504.2 6 bp overlap

HOXD4 2 datasets

Motif DE_60h DE_60h-HOXD4_MA1507.2 6 bp overlap

Motif DE_72h DE_72h-HOXD4_MA1507.2 6 bp overlap

IKZF1 1 dataset

ChIP K-562 ENCSR395HWC.IKZF1.K-562 531 bp overlap

IRF3 2 datasets

Motif DE_60h DE_60h-IRF3_MA1418.2 17 bp overlap

Motif DE_72h DE_72h-IRF3_MA1418.2 17 bp overlap

IRF4 2 datasets

Motif DE_60h DE_60h-IRF4_MA1419.2 14 bp overlap

Motif DE_72h DE_72h-IRF4_MA1419.2 14 bp overlap

IRF6 2 datasets

Motif DE_60h DE_60h-IRF6_MA1509.1 9 bp overlap

Motif DE_72h DE_72h-IRF6_MA1509.1 9 bp overlap

IRF7 2 datasets

Motif DE_60h DE_60h-IRF7_MA0772.2 13 bp overlap

Motif DE_72h DE_72h-IRF7_MA0772.2 13 bp overlap

IRF8 2 datasets

Motif DE_60h DE_60h-IRF8_MA0652.2 13 bp overlap

Motif DE_72h DE_72h-IRF8_MA0652.2 13 bp overlap

IRF9 2 datasets

Motif DE_60h DE_60h-IRF9_MA0653.1 15 bp overlap

Motif DE_72h DE_72h-IRF9_MA0653.1 15 bp overlap

Irf1 2 datasets

Motif DE_60h DE_60h-Irf1_MA0050.4 11 bp overlap

Motif DE_72h DE_72h-Irf1_MA0050.4 11 bp overlap

KLF17 2 datasets

Motif DE_60h DE_60h-KLF17_MA1514.2 14 bp overlap

Motif DE_72h DE_72h-KLF17_MA1514.2 14 bp overlap

MEF2D 3 datasets

ChIP retina_Hu13 GSE137311.MEF2D.retina_Hu13 447 bp overlap

ChIP retina_Hu21 GSE137311.MEF2D.retina_Hu21 450 bp overlap

ChIP retina_Hu25 GSE137311.MEF2D.retina_Hu25 497 bp overlap

MXI1 2 datasets

Motif DE_60h DE_60h-MXI1_MA1108.3 6 bp overlap

Motif DE_72h DE_72h-MXI1_MA1108.3 6 bp overlap

Mafb 2 datasets

Motif DE_60h DE_60h-Mafb_MA0117.3 11 bp overlap

Motif DE_72h DE_72h-Mafb_MA0117.3 11 bp overlap

NEUROD1 4 datasets

ChIP D283-Med GSE92582.NEUROD1.D283-Med 410 bp overlap

ChIP D283-Med_shNEUROD1-1579 GSE92582.NEUROD1.D283-Med_shNEUROD1-1579 321 bp overlap

ChIP D341-Med_shNEUROD1-1154 GSE92582.NEUROD1.D341-Med_shNEUROD1-1154 230 bp overlap

ChIP D341-Med_shNEUROD1-1579 GSE92582.NEUROD1.D341-Med_shNEUROD1-1579 349 bp overlap

NFATC3 2 datasets

Motif DE_60h DE_60h-NFATC3_MA0625.3 6 bp overlap

Motif DE_72h DE_72h-NFATC3_MA0625.3 6 bp overlap

NFATC4 2 datasets

Motif DE_60h DE_60h-NFATC4_MA1525.3 9 bp overlap

Motif DE_72h DE_72h-NFATC4_MA1525.3 9 bp overlap

Motif DE_60h DE_60h-NRL_MA0842.3 12 bp overlap

Motif DE_72h DE_72h-NRL_MA0842.3 12 bp overlap

ChIP retina_Hu13 GSE137311.NRL.retina_Hu13 402 bp overlap

Nfat5 2 datasets

Motif DE_60h DE_60h-Nfat5_MA0606.3 8 bp overlap

Motif DE_72h DE_72h-Nfat5_MA0606.3 8 bp overlap

Nfatc1 2 datasets

Motif DE_60h DE_60h-Nfatc1_MA0624.3 6 bp overlap

Motif DE_72h DE_72h-Nfatc1_MA0624.3 6 bp overlap

Nfatc2 2 datasets

Motif DE_60h DE_60h-Nfatc2_MA0152.3 8 bp overlap

Motif DE_72h DE_72h-Nfatc2_MA0152.3 8 bp overlap

ChIP retina_Hu7 GSE137311.OTX2.retina_Hu7 537 bp overlap

ChIP GM12878 ENCSR000BGR.PBX3.GM12878 100 bp overlap

POLR2A 1 dataset

ChIP spleen ENCFF044PYR 57 bp overlap

POU1F1 2 datasets

Motif DE_60h DE_60h-POU1F1_MA0784.3 14 bp overlap

Motif DE_72h DE_72h-POU1F1_MA0784.3 14 bp overlap

POU2F2 2 datasets

Motif DE_60h DE_60h-POU2F2_MA0507.3 13 bp overlap

Motif DE_72h DE_72h-POU2F2_MA0507.3 13 bp overlap

POU3F1 2 datasets

Motif DE_60h DE_60h-POU3F1_MA0786.2 10 bp overlap

Motif DE_72h DE_72h-POU3F1_MA0786.2 10 bp overlap

POU3F2 2 datasets

Motif DE_60h DE_60h-POU3F2_MA0787.1 12 bp overlap

Motif DE_72h DE_72h-POU3F2_MA0787.1 12 bp overlap

POU3F3 2 datasets

Motif DE_60h DE_60h-POU3F3_MA0788.1 13 bp overlap

Motif DE_72h DE_72h-POU3F3_MA0788.1 13 bp overlap

POU3F4 2 datasets

Motif DE_60h DE_60h-POU3F4_MA0789.1 9 bp overlap

Motif DE_72h DE_72h-POU3F4_MA0789.1 9 bp overlap

PRDM10 1 dataset

ChIP HEK293 ENCFF145WQQ 271 bp overlap

Motif DE_60h DE_60h-Pgr_MA2323.1 17 bp overlap

Motif DE_72h DE_72h-Pgr_MA2323.1 17 bp overlap

Prdm5 2 datasets

Motif DE_60h DE_60h-Prdm5_MA1999.2 11 bp overlap

Motif DE_72h DE_72h-Prdm5_MA1999.2 11 bp overlap

RBBP5 1 dataset

ChIP WA01 ENCSR000AQC.RBBP5.WA01 135 bp overlap

RBPJ 2 datasets

Motif DE_60h DE_60h-RBPJ_MA1116.2 6 bp overlap

Motif DE_72h DE_72h-RBPJ_MA1116.2 6 bp overlap

ChIP retina_Hu22 GSE137311.RORB.retina_Hu22 567 bp overlap

RUNX2 2 datasets

Motif DE_60h DE_60h-RUNX2_MA0511.2 9 bp overlap

Motif DE_72h DE_72h-RUNX2_MA0511.2 9 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.RXR.pancreatic-progenitor_PP1 154 bp overlap

Runx1 2 datasets

Motif DE_60h DE_60h-Runx1_MA0002.3 9 bp overlap

Motif DE_72h DE_72h-Runx1_MA0002.3 9 bp overlap

SIX1 2 datasets

Motif DE_60h DE_60h-SIX1_MA1118.2 9 bp overlap

Motif DE_72h DE_72h-SIX1_MA1118.2 9 bp overlap

SIX2 3 datasets

Motif DE_60h DE_60h-SIX2_MA1119.2 11 bp overlap

Motif DE_72h DE_72h-SIX2_MA1119.2 11 bp overlap

ChIP HEK GSE73865.SIX2.HEK 168 bp overlap

SMAD2-3 1 dataset

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 426 bp overlap

SOX10 2 datasets

Motif DE_60h DE_60h-SOX10_MA0442.3 6 bp overlap

Motif DE_72h DE_72h-SOX10_MA0442.3 6 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 199 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 520 bp overlap

STAT1::STAT2 2 datasets

Motif DE_60h DE_60h-STAT1STAT2_MA0517.2 13 bp overlap

Motif DE_72h DE_72h-STAT1STAT2_MA0517.2 13 bp overlap

STAT3 1 dataset

ChIP T-47D_JC5056 GSE126004.STAT3.T-47D_JC5056 234 bp overlap

SUZ12 1 dataset

ChIP CRL-7250_shSS18 GSE108025.SUZ12.CRL-7250_shSS18 81 bp overlap

Six4 2 datasets

Motif DE_60h DE_60h-Six4_MA2001.2 7 bp overlap

Motif DE_72h DE_72h-Six4_MA2001.2 7 bp overlap

Stat2 2 datasets

Motif DE_60h DE_60h-Stat2_MA1623.2 10 bp overlap

Motif DE_72h DE_72h-Stat2_MA1623.2 10 bp overlap

ChIP CHRF28811 ERP008568.TAL1.CHRF28811 79 bp overlap

TFAP2B 1 dataset

ChIP SK-N-SH ENCFF869XXQ 95 bp overlap

TFAP2C 1 dataset

ChIP UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc 210 bp overlap

ZBTB2 1 dataset

ChIP GM12878 GSE97661.ZBTB2.GM12878 97 bp overlap

ZKSCAN1 4 datasets

ChIP HeLa-S3 ENCSR000ECJ.ZKSCAN1.HeLa-S3 137 bp overlap

ChIP Hep-G2 ENCSR157CAU.ZKSCAN1.Hep-G2 156 bp overlap

ChIP K-562 ENCSR882ERE.ZKSCAN1.K-562 501 bp overlap

ChIP K562 ENCFF977CBA 357 bp overlap

ZNF135 1 dataset

Motif DE_72h DE_72h-ZNF135_MA1587.1 14 bp overlap

ZNF317 2 datasets

Motif DE_60h DE_60h-ZNF317_MA1593.2 8 bp overlap

Motif DE_72h DE_72h-ZNF317_MA1593.2 8 bp overlap

ZNF354C 2 datasets

Motif DE_60h DE_60h-ZNF354C_MA0130.1 6 bp overlap

Motif DE_72h DE_72h-ZNF354C_MA0130.1 6 bp overlap

ZNF558 2 datasets

Motif DE_60h DE_60h-ZNF558_MA2335.1 29 bp overlap

Motif DE_72h DE_72h-ZNF558_MA2335.1 29 bp overlap

ZNF777 1 dataset

ChIP HEK293T GSE78099.ZNF777.HEK293T 164 bp overlap

ZSCAN4 2 datasets

Motif DE_60h DE_60h-ZSCAN4_MA1155.1 15 bp overlap

Motif DE_72h DE_72h-ZSCAN4_MA1155.1 15 bp overlap

Zfp809 2 datasets

Motif DE_60h DE_60h-Zfp809_MA2125.1 9 bp overlap

Motif DE_72h DE_72h-Zfp809_MA2125.1 9 bp overlap