VPS37C is a subunit of ESCRT-I (endosomal sorting complex required for transport I), a complex in the class E vacuolar protein sorting (VPS) pathway required for sorting ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies (Eastman et al., 2005 [PubMed 15509564]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for VPS37C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VPS37C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VPS37C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:60,906,047–60,907,006 | 254.8 kb | Distal (>10kb) Multiome | 787 | |
| chr11:60,913,771–60,914,957 | 247.3 kb | Distal (>10kb) Multiome | 710 | |
| chr11:60,915,279–60,915,720 | 245.8 kb | Distal (>10kb) Multiome | 296 | |
| chr11:60,923,955–60,925,328 | 236.9 kb | Distal (>10kb) Multiome | 668 | |
| chr11:60,950,921–60,951,656 | 210.2 kb | Distal (>10kb) Multiome | 171 | |
| chr11:61,007,475–61,008,948 | 153.2 kb | Distal (>10kb) Multiome | 268 | |
| chr11:61,010,497–61,011,303 | 150.6 kb | Distal (>10kb) Multiome | 81 | |
| chr11:61,158,562–61,159,021 | 2.6 kb | Proximal (<10kb) Multiome | 223 | |
| chr11:61,160,742–61,162,049 | 66 bp | At TSS Multiome | 851 | |
| chr11:61,164,843–61,164,966 | 3.4 kb | Proximal (<10kb) | 105 | |
| chr11:61,165,101–61,165,235 | 3.6 kb | Proximal (<10kb) | 139 | |
| chr11:61,281,385–61,282,193 | 120.3 kb | Distal (>10kb) Multiome | 231 | |
| chr11:61,294,197–61,295,784 | 133.8 kb | Distal (>10kb) Multiome | 761 | |
| chr11:61,332,596–61,333,687 | 171.7 kb | Distal (>10kb) Multiome | 897 | |
| chr11:61,361,602–61,362,481 | 200.7 kb | Distal (>10kb) Multiome | 905 | |
| chr11:61,392,209–61,392,929 | 231.1 kb | Distal (>10kb) Multiome | 800 | |
| chr11:61,429,326–61,430,423 | 268.5 kb | Distal (>10kb) Multiome | 975 |
Genomic view of the VPS37C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.