Enables identical protein binding activity and ubiquitin-ubiquitin ligase activity. Involved in several processes, including DNA damage checkpoint signaling; mRNA splicing, via spliceosome; and protein K63-linked ubiquitination. Acts upstream of or within protein polyubiquitination. Located in cytoplasm; nuclear lumen; and site of double-strand break. Part of Prp19 complex and U2-type catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PRPF19. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRPF19 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRPF19, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:60,775,417–60,775,969 | 131.0 kb | Distal (>10kb) Multiome | 374 | |
| chr11:60,841,541–60,842,740 | 64.6 kb | Distal (>10kb) Multiome | 839 | |
| chr11:60,852,120–60,853,076 | 53.8 kb | Distal (>10kb) Multiome | 186 | |
| chr11:60,899,443–60,899,607 | 7.0 kb | Proximal (<10kb) | 158 | |
| chr11:60,906,047–60,907,006 | 27 bp | At TSS Multiome | 787 | |
| chr11:60,913,771–60,914,957 | 7.5 kb | Proximal (<10kb) Multiome | 710 | |
| chr11:60,915,279–60,915,720 | 9.0 kb | Proximal (<10kb) Multiome | 296 | |
| chr11:60,923,955–60,925,328 | 17.9 kb | Distal (>10kb) Multiome | 668 | |
| chr11:60,950,921–60,951,656 | 44.6 kb | Distal (>10kb) Multiome | 171 | |
| chr11:61,007,475–61,008,948 | 101.6 kb | Distal (>10kb) Multiome | 268 | |
| chr11:61,010,497–61,011,303 | 104.2 kb | Distal (>10kb) Multiome | 81 | |
| chr11:61,158,562–61,159,021 | 252.2 kb | Distal (>10kb) Multiome | 223 | |
| chr11:61,160,742–61,162,049 | 254.9 kb | Distal (>10kb) Multiome | 851 |
Genomic view of the PRPF19 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.