chr4:2,886,596–2,887,030

chr4 : 2,886,596 – 2,887,030

434 bp 64 TFs 8 linked genes

This 434 bp open chromatin element is linked to 8 target genes and is bound by 64 transcription factors.

Linked Genes

8 genes

Gene	Expression	Dist. to TSS	Distance	Link type
ADD1		42.9 kb	Distal	Multiome
MFSD10		47.9 kb	Distal	Multiome
NOP14-AS1		48.0 kb	Distal	Multiome
NOP14		76.5 kb	Distal	Multiome
GRK4		76.7 kb	Distal	Multiome
SH3BP2		93.9 kb	Distal	Multiome
TNIP2		130.5 kb	Distal	Multiome+HiCAR
HTT		187.8 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

64 transcription factors

ARID1A 1 dataset

ChIP NGP GSE134626.ARID1A.NGP 426 bp overlap

ARID2 1 dataset

ChIP NGP GSE134626.ARID2.NGP 238 bp overlap

ASCL1 1 dataset

ChIP NCI-H82 GSE69394.ASCL1.NCI-H82 212 bp overlap

ChIP metastatic-neuroblastoma_SKNMM GSE100148.ATRX.metastatic-neuroblastoma_SKNMM 315 bp overlap

BRD4 6 datasets

ChIP Kelly_resistant GSE103030.BRD4.Kelly_resistant 187 bp overlap

ChIP Kelly_sensitive GSE103030.BRD4.Kelly_sensitive 231 bp overlap

ChIP MV4-11_IBET151_5000nM GSE120715.BRD4.MV4-11_IBET151_5000nM 166 bp overlap

ChIP SK-N-BE2-C_Naive-veh GSE107706.BRD4.SK-N-BE2-C_Naive-veh 405 bp overlap

ChIP SK-N-BE2-C_Resistant-veh GSE107706.BRD4.SK-N-BE2-C_Resistant-veh 252 bp overlap

ChIP retina_AB1-RB GSE86981.BRD4.retina_AB1-RB 199 bp overlap

CHD2 2 datasets

ChIP SK-N-SH ENCFF669KMB 361 bp overlap

ChIP SK-N-SH ENCSR274SLQ.CHD2.SK-N-SH 400 bp overlap

CTCF 3 datasets

ChIP heart_left-ventricle ENCSR791AYW.CTCF.heart_left-ventricle 180 bp overlap

ChIP heart_left-ventricle ENCSR544APK.CTCF.heart_left-ventricle 201 bp overlap

ChIP retina_Hu25 GSE137311.CTCF.retina_Hu25 307 bp overlap

EBF3_P177L 1 dataset

ChIP SK-N-SH GSE90682.EBF3_P177L.SK-N-SH 337 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 251 bp overlap

EP300 4 datasets

ChIP SK-N-SH ENCFF829RWA 208 bp overlap

ChIP SK-N-SH ENCSR000EHV.EP300.SK-N-SH 294 bp overlap

ChIP SK-N-SH ENCSR000BUA.EP300.SK-N-SH 143 bp overlap

ChIP neural ENCSR843ZUP.EP300.neural 291 bp overlap

ChIP VCaP_ETOH GSE49091.ERG.VCaP_ETOH 203 bp overlap

ESR1 7 datasets

ChIP MCF-7 GSE117492.ESR1.MCF-7 84 bp overlap

ChIP T-47D GSE148277.ESR1.T-47D 333 bp overlap

ChIP T-47D_D538G_E2 GSE148277.ESR1.T-47D_D538G_E2 128 bp overlap

ChIP ZR751 ERP000783.ESR1.ZR751 273 bp overlap

ChIP ZR751_E2 GSE72249.ESR1.ZR751_E2 304 bp overlap

ChIP breast-cancer_S176 GSE128018.ESR1.breast-cancer_S176 114 bp overlap

ChIP breast-cancer_S440-2187 GSE128018.ESR1.breast-cancer_S440-2187 150 bp overlap

ESR1_pS118 1 dataset

ChIP MCF-7_E2_sc GSE117569.ESR1_pS118.MCF-7_E2_sc 275 bp overlap

ESRRG 1 dataset

ChIP cardiomyocyte GSE113760.ESRRG.cardiomyocyte 321 bp overlap

FOXA1 2 datasets

ChIP ZR751_E2 GSE72249.FOXA1.ZR751_E2 107 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.FOXA1.pancreatic-progenitor_PP1 198 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 434 bp overlap

ChIP DE DE-FOXA2-2 381 bp overlap

FOXJ3 1 dataset

ChIP SK-N-SH ENCFF124KVL 429 bp overlap

GATA2 4 datasets

ChIP SH-SY5Y ENCFF485YIB 211 bp overlap

ChIP SH-SY5Y ENCSR000EYB.GATA2.SH-SY5Y 351 bp overlap

ChIP SK-N-SH ENCFF764OZD 171 bp overlap

ChIP SK-N-SH ENCSR706VOO.GATA2.SK-N-SH 299 bp overlap

GATA3 6 datasets

ChIP BE2C GSE65664.GATA3.BE2C 215 bp overlap

ChIP Kelly GSE65664.GATA3.Kelly 314 bp overlap

ChIP Kelly GSE94822.GATA3.Kelly 215 bp overlap

ChIP SH-SY5Y ENCSR000EXZ.GATA3.SH-SY5Y 247 bp overlap

ChIP SK-N-BE2-C GSE94822.GATA3.SK-N-BE2-C 283 bp overlap

ChIP SK-N-SH ENCFF040SSB 365 bp overlap

GATA4 9 datasets

ChIP DE DE-GATA4-1 388 bp overlap

ChIP DE DE-GATA4-2 434 bp overlap

ChIP G296S GSE85628.GATA4.G296S 279 bp overlap

ChIP G296S_2 GSE85628.GATA4.G296S_2 279 bp overlap

ChIP cardiomyocyte GSE85628.GATA4.cardiomyocyte 239 bp overlap

ChIP cardiomyocyte_1 GSE85628.GATA4.cardiomyocyte_1 239 bp overlap

ChIP cardiomyocyte_5 GSE85628.GATA4.cardiomyocyte_5 275 bp overlap

ChIP cardiomyocyte_7 GSE85628.GATA4.cardiomyocyte_7 434 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 322 bp overlap

GATA6 10 datasets

ChIP DE DE-GATA6-1 350 bp overlap

ChIP DE DE-GATA6-2 434 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 299 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 339 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 273 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 314 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 355 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 298 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 301 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA6.pancreatic-progenitor_PP1 293 bp overlap

GLIS3 1 dataset

ChIP SK-N-SH_all-trans-retinoic-acid_6-uM_48-hour ENCSR507BWM.GLIS3.SK-N-SH_all-trans-retinoic-acid_6-uM_48-hour 140 bp overlap

HAND2 3 datasets

ChIP CLB-Ga GSE90683.HAND2.CLB-Ga 434 bp overlap

ChIP Kelly GSE94822.HAND2.Kelly 434 bp overlap

ChIP SK-N-BE2-C GSE94822.HAND2.SK-N-BE2-C 434 bp overlap

ISL1 2 datasets

ChIP SK-N-BE2-C GSE94822.ISL1.SK-N-BE2-C 434 bp overlap

ChIP SK-N-SH ENCFF285GEQ 410 bp overlap

KDM1A 2 datasets

ChIP SH-SY5Y_B0 GSE58258.KDM1A.SH-SY5Y_B0 177 bp overlap

ChIP SH-SY5Y_B3 GSE58258.KDM1A.SH-SY5Y_B3 399 bp overlap

ChIP islet ERP004003.MAFB.islet 257 bp overlap

MAML3 1 dataset

ChIP SK-N-SH GSE69119.MAML3.SK-N-SH 344 bp overlap

ChIP NCI-H2171 GSE41105.MAX.NCI-H2171 327 bp overlap

ChIP NCI-H2171 GSE36354.MAX.NCI-H2171 168 bp overlap

MXI1 2 datasets

ChIP SK-N-SH ENCFF746HVJ 414 bp overlap

ChIP SK-N-SH ENCSR000EIA.MXI1.SK-N-SH 346 bp overlap

ChIP NCI-H2171 GSE36354.MYC.NCI-H2171 173 bp overlap

MYCN 5 datasets

ChIP COG-N-415 GSE138295.MYCN.COG-N-415 385 bp overlap

ChIP Kelly GSE94822.MYCN.Kelly 236 bp overlap

ChIP Kelly_sensitive GSE115249.MYCN.Kelly_sensitive 203 bp overlap

ChIP LA-N-5 GSE138295.MYCN.LA-N-5 404 bp overlap

ChIP SK-N-BE2-C GSE94822.MYCN.SK-N-BE2-C 237 bp overlap

NEUROD1 1 dataset

ChIP D341-Med_shGFP GSE92582.NEUROD1.D341-Med_shGFP 288 bp overlap

NKX2-5 2 datasets

ChIP hESC_ab3584 GSE89457.NKX2-5.hESC_ab3584 294 bp overlap

ChIP hESC_sc-14033 GSE89457.NKX2-5.hESC_sc-14033 169 bp overlap

NKX3-1 1 dataset

ChIP islet ERP004003.NKX3-1.islet 272 bp overlap

PAX3-FOXO1 1 dataset

ChIP RH4 GSE140115.PAX3-FOXO1.RH4 274 bp overlap

ChIP SK-N-SH ENCFF876BMC 199 bp overlap

PDX1 2 datasets

ChIP hiPSC GSE125768.PDX1.hiPSC 298 bp overlap

ChIP islet ERP001456.PDX1.islet 135 bp overlap

PHOX2B 2 datasets

ChIP CLB-Ga GSE90683.PHOX2B.CLB-Ga 434 bp overlap

ChIP SK-N-BE2-C GSE94822.PHOX2B.SK-N-BE2-C 390 bp overlap

PITX3 1 dataset

ChIP SH-SY5Y GSE93275.PITX3.SH-SY5Y 434 bp overlap

POLR2A 2 datasets

ChIP SK-N-SH ENCFF683PFH 216 bp overlap

ChIP neural cell ENCFF604SPB 261 bp overlap

RAD21 4 datasets

ChIP SK-N-SH ENCFF747MAS 251 bp overlap

ChIP SK-N-SH ENCSR000EHX.RAD21.SK-N-SH 189 bp overlap

ChIP neural ENCSR198ZYJ.RAD21.neural 257 bp overlap

ChIP neural cell ENCFF564MOT 406 bp overlap

ChIP hiPSC_D5 GSE132532.RARA.hiPSC_D5 350 bp overlap

RCOR1 2 datasets

ChIP SK-N-SH ENCFF518EXB 232 bp overlap

ChIP SK-N-SH ENCSR009TKN.RCOR1.SK-N-SH 434 bp overlap

ChIP neural ENCSR000BTV.REST.neural 239 bp overlap

ChIP SK-N-SH ENCFF755HLO 341 bp overlap

SIN3A 1 dataset

ChIP SK-N-SH ENCSR000BPB.SIN3A.SK-N-SH 293 bp overlap

SMAD2-3 2 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 422 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 243 bp overlap

SMAD2_3 3 datasets

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 252 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 401 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 303 bp overlap

SMARCA4 4 datasets

ChIP NGP GSE134626.SMARCA4.NGP 336 bp overlap

ChIP NGP_ARID1A-het GSE134626.SMARCA4.NGP_ARID1A-het 389 bp overlap

ChIP NGP_ARID1A-mut1 GSE134626.SMARCA4.NGP_ARID1A-mut1 350 bp overlap

ChIP NGP_ARID1A-mut2 GSE134626.SMARCA4.NGP_ARID1A-mut2 434 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 282 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 392 bp overlap

ChIP HEK293 ENCFF733RBE 434 bp overlap

ChIP HEK293 ENCSR468IJT.SP7.HEK293 288 bp overlap

ChIP NGP_ARID1A-mut1 GSE134626.SS18.NGP_ARID1A-mut1 239 bp overlap

ChIP erythroid GSE42390.TAL1.erythroid 178 bp overlap

TBX2 2 datasets

ChIP Kelly GSE94822.TBX2.Kelly 331 bp overlap

ChIP SK-N-BE2-C GSE94822.TBX2.SK-N-BE2-C 406 bp overlap

TBX5 5 datasets

ChIP G296S GSE85628.TBX5.G296S 304 bp overlap

ChIP G296S_2 GSE85628.TBX5.G296S_2 304 bp overlap

ChIP G296S_4 GSE85628.TBX5.G296S_4 169 bp overlap

ChIP cardiomyocyte_7 GSE85628.TBX5.cardiomyocyte_7 259 bp overlap

ChIP hiPSC GSE81585.TBX5.hiPSC 297 bp overlap

TCF12 1 dataset

ChIP SK-N-SH ENCFF147AHB 281 bp overlap

TCF4 2 datasets

ChIP SH-SY5Y GSE96915.TCF4.SH-SY5Y 288 bp overlap

ChIP SK-N-SH ENCFF270OWF 260 bp overlap

TEAD4 6 datasets

ChIP BE2C GSE84389.TEAD4.BE2C 354 bp overlap

ChIP MCF-7_BLRP_WT_Veh GSE125594.TEAD4.MCF-7_BLRP_WT_Veh 272 bp overlap

ChIP SK-N-BE2 GSE84389.TEAD4.SK-N-BE2 354 bp overlap

ChIP SK-N-SH ENCFF754TJT 401 bp overlap

ChIP SK-N-SH ENCSR000BUQ.TEAD4.SK-N-SH 190 bp overlap

ChIP hMSC-TERT4 GSE140782.TEAD4.hMSC-TERT4 177 bp overlap

TFAP2B 1 dataset

ChIP SK-N-SH ENCFF869XXQ 412 bp overlap

TRPS1 1 dataset

ChIP MCF-7 GSE133072.TRPS1.MCF-7 206 bp overlap

TSHZ2 2 datasets

ChIP SK-N-SH ENCFF182EBB 381 bp overlap

ChIP SK-N-SH_all-trans-retinoic-acid_6-uM_48-hour ENCSR282NLQ.TSHZ2.SK-N-SH_all-trans-retinoic-acid_6-uM_48-hour 302 bp overlap

TWIST1 2 datasets

ChIP BE2C GSE80151.TWIST1.BE2C 368 bp overlap

ChIP SK-N-BE2-C GSE80151.TWIST1.SK-N-BE2-C 368 bp overlap

ChIP hiPSC GSE111930.YAP1.hiPSC 160 bp overlap