This gene encodes a protein that plays a role in pre-18s rRNA processing and small ribosomal subunit assembly. The encoded protein may be involved in the regulation of pancreatic cancer cell proliferation and migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Transcription factors with Perturb-seq knockdown data for NOP14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NOP14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NOP14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:2,755,816–2,757,021 | 207.0 kb | Distal (>10kb) Multiome | 760 | |
| chr4:2,763,947–2,764,427 | 199.1 kb | Distal (>10kb) Multiome | 311 | |
| chr4:2,792,387–2,793,280 | 170.4 kb | Distal (>10kb) Multiome | 561 | |
| chr4:2,800,892–2,801,392 | 162.3 kb | Distal (>10kb) Multiome | 538 | |
| chr4:2,817,772–2,818,865 | 145.1 kb | Distal (>10kb) Multiome | 350 | |
| chr4:2,843,009–2,844,539 | 119.6 kb | Distal (>10kb) Multiome | 762 | |
| chr4:2,867,740–2,868,353 | 95.3 kb | Distal (>10kb) Multiome | 232 | |
| chr4:2,886,596–2,887,030 | 76.5 kb | Distal (>10kb) Multiome | 64 | |
| chr4:2,922,643–2,923,182 | 40.5 kb | Distal (>10kb) Multiome | 115 | |
| chr4:2,934,626–2,935,335 | 28.5 kb | Distal (>10kb) Multiome | 661 | |
| chr4:2,962,729–2,964,377 | 106 bp | At TSS Multiome | 1035 | |
| chr4:3,073,152–3,075,706 | 110.9 kb | Distal (>10kb) Multiome | 810 |
Genomic view of the NOP14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.