GRK4

G protein-coupled receptor kinase 4 | GPRK4, GPRK2L

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Biological processes 18 terms

ATP binding (GO:0005524)G protein-coupled receptor kinase activity (GO:0004703)cell cortex (GO:0005938)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)photoreceptor disc membrane (GO:0097381)protein binding (GO:0005515)protein kinase activity (GO:0004672)protein kinase activity (GO:0004672)protein serine/threonine kinase activity (GO:0004674)receptor internalization (GO:0031623)regulation of G protein-coupled receptor signaling pathway (GO:0008277)regulation of G protein-coupled receptor signaling pathway (GO:0008277)regulation of opsin-mediated signaling pathway (GO:0022400)regulation of signal transduction (GO:0009966)rhodopsin kinase activity (GO:0050254)signal transduction (GO:0007165)

Expression (TPM)

TFs regulating GRK4 0 TFs

Transcription factors with Perturb-seq knockdown data for GRK4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GRK4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to GRK4

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GRK4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr4:2,755,816–2,757,021	207.2 kb	Distal (>10kb) Multiome	760
chr4:2,763,947–2,764,427	199.3 kb	Distal (>10kb) Multiome	311
chr4:2,792,387–2,793,280	170.6 kb	Distal (>10kb) Multiome	561
chr4:2,800,892–2,801,392	162.5 kb	Distal (>10kb) Multiome	538
chr4:2,817,772–2,818,865	145.3 kb	Distal (>10kb) Multiome	350
chr4:2,843,009–2,844,539	119.8 kb	Distal (>10kb) Multiome	762
chr4:2,867,740–2,868,353	95.5 kb	Distal (>10kb) Multiome	232
chr4:2,886,596–2,887,030	76.7 kb	Distal (>10kb) Multiome	64
chr4:2,922,643–2,923,182	40.7 kb	Distal (>10kb) Multiome	115
chr4:2,934,626–2,935,335	28.7 kb	Distal (>10kb) Multiome	661
chr4:2,962,729–2,964,377	96 bp	At TSS Multiome	1035
chr4:3,073,152–3,075,706	110.7 kb	Distal (>10kb) Multiome	810

Genome Browser

Genomic view of the GRK4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.