Enables transcription coactivator activity. Involved in Notch signaling pathway and positive regulation of transcription by RNA polymerase II. Located in nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MAML3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAML3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAML3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:139,665,282–139,666,449 | 488.4 kb | Distal (>10kb) Multiome HiCAR | 844 | |
| chr4:139,667,275–139,669,052 | 485.9 kb | Distal (>10kb) Multiome HiCAR | 181 | |
| chr4:139,669,155–139,671,298 | 484.2 kb | Distal (>10kb) Multiome HiCAR | 252 | |
| chr4:139,734,753–139,735,998 | 419.1 kb | Distal (>10kb) Multiome HiCAR | 441 | |
| chr4:139,875,243–139,875,853 | 278.6 kb | Distal (>10kb) Multiome | 198 | |
| chr4:140,049,021–140,049,762 | 104.9 kb | Distal (>10kb) Multiome | 303 | |
| chr4:140,092,187–140,093,074 | 61.5 kb | Distal (>10kb) Multiome | 350 | |
| chr4:140,094,588–140,096,104 | 59.0 kb | Distal (>10kb) Multiome | 411 | |
| chr4:140,150,268–140,153,432 | 2.3 kb | Proximal (<10kb) Multiome | 813 | |
| chr4:140,153,751–140,154,614 | 85 bp | At TSS Multiome | 861 | |
| chr4:140,212,328–140,214,033 | 58.8 kb | Distal (>10kb) Multiome HiCAR | 74 | |
| chr4:140,218,608–140,219,888 | 65.0 kb | Distal (>10kb) Multiome HiCAR | 75 | |
| chr4:140,237,447–140,238,937 | 83.6 kb | Distal (>10kb) Multiome HiCAR | 397 | |
| chr4:140,252,035–140,253,792 | 99.0 kb | Distal (>10kb) Multiome HiCAR | 580 | |
| chr4:140,349,706–140,350,239 | 195.8 kb | Distal (>10kb) Multiome HiCAR | 64 | |
| chr4:140,357,429–140,358,616 | 203.9 kb | Distal (>10kb) Multiome | 90 | |
| chr4:140,372,701–140,374,405 | 219.4 kb | Distal (>10kb) Multiome | 837 | |
| chr4:140,426,688–140,428,067 | 273.4 kb | Distal (>10kb) Multiome | 896 |
Genomic view of the MAML3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.