MFSD10

solute carrier family 75 member 1 | IT10C3, SLC75A1, TETRAN, MFSD10

This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein likely functions in efflux of organic anions, including the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]

Member of: DE-1 DE-1.30 Developmental clusters: GC6

Biological processes 14 terms

brush border membrane (GO:0031526)brush border membrane (GO:0031526)cytoplasmic vesicle membrane (GO:0030659)membrane (GO:0016020)nuclear inner membrane (GO:0005637)nuclear inner membrane (GO:0005637)plasma membrane (GO:0005886)protein binding (GO:0005515)sodium-independent organic anion transport (GO:0043252)tetracycline transmembrane transport (GO:0015904)tetracycline transmembrane transporter activity (GO:0008493)transmembrane transport (GO:0055085)transmembrane transporter activity (GO:0022857)transmembrane transporter activity (GO:0022857)

Expression (TPM)

TFs regulating MFSD10 0 TFs

Transcription factors with Perturb-seq knockdown data for MFSD10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MFSD10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to MFSD10

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MFSD10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr4:2,755,816–2,757,021	178.5 kb	Distal (>10kb) Multiome HiCAR	760
chr4:2,763,947–2,764,427	170.6 kb	Distal (>10kb) Multiome	311
chr4:2,792,387–2,793,280	141.8 kb	Distal (>10kb) Multiome	561
chr4:2,800,892–2,801,392	133.7 kb	Distal (>10kb) Multiome	538
chr4:2,817,772–2,818,865	116.6 kb	Distal (>10kb) Multiome	350
chr4:2,843,009–2,844,539	91.0 kb	Distal (>10kb) Multiome	762
chr4:2,867,740–2,868,353	66.8 kb	Distal (>10kb) Multiome	232
chr4:2,886,596–2,887,030	47.9 kb	Distal (>10kb) Multiome	64
chr4:2,922,643–2,923,182	12.0 kb	Distal (>10kb) Multiome	115
chr4:2,933,826–2,934,574	259 bp	At TSS	283
chr4:2,934,626–2,935,335	7 bp	At TSS Multiome	661
chr4:2,935,874–2,936,152	1.0 kb	Proximal (<10kb)	245
chr4:2,962,729–2,964,377	28.6 kb	Distal (>10kb) Multiome	1035
chr4:3,073,152–3,075,706	139.5 kb	Distal (>10kb) Multiome	810

Genome Browser

Genomic view of the MFSD10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.