Adducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, and gamma). Adducin acts as a heterodimer of the related alpha, beta, or gamma subunits. The protein encoded by this gene represents the alpha subunit. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. [provided by RefSeq, Aug 2017]
Transcription factors with Perturb-seq knockdown data for ADD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:2,755,816–2,757,021 | 87.6 kb | Distal (>10kb) Multiome | 760 | |
| chr4:2,763,947–2,764,427 | 79.7 kb | Distal (>10kb) Multiome | 311 | |
| chr4:2,792,387–2,793,280 | 51.0 kb | Distal (>10kb) Multiome | 561 | |
| chr4:2,800,892–2,801,392 | 42.8 kb | Distal (>10kb) Multiome | 538 | |
| chr4:2,817,772–2,818,865 | 25.7 kb | Distal (>10kb) Multiome | 350 | |
| chr4:2,843,009–2,844,539 | 142 bp | At TSS Multiome | 762 | |
| chr4:2,867,740–2,868,353 | 24.1 kb | Distal (>10kb) Multiome | 232 | |
| chr4:2,886,596–2,887,030 | 42.9 kb | Distal (>10kb) Multiome | 64 | |
| chr4:2,922,643–2,923,182 | 78.9 kb | Distal (>10kb) Multiome | 115 | |
| chr4:2,934,626–2,935,335 | 90.9 kb | Distal (>10kb) Multiome | 661 | |
| chr4:2,962,729–2,964,377 | 119.5 kb | Distal (>10kb) Multiome | 1035 | |
| chr4:3,073,152–3,075,706 | 230.3 kb | Distal (>10kb) Multiome | 810 |
Genomic view of the ADD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.