chr2:176,192,304–176,192,888

chr2 : 176,192,304 – 176,192,888

584 bp 56 TFs 5 linked genes

This 584 bp open chromatin element is linked to 5 target genes and is bound by 56 transcription factors.

Linked Genes

5 genes

Gene	Expression	Dist. to TSS	Distance	Link type
ENSG00000279160		at TSS	At TSS	Proximity
MIR7704		3.5 kb	Proximal	Proximity
HOXD1		3.6 kb	Proximal	Proximity
HAGLR		3.7 kb	Proximal	Proximity
ENSG00000218175		8.4 kb	Proximal	Proximity

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

56 transcription factors

BCOR 3 datasets

ChIP WA01 GSE104690.BCOR.WA01 491 bp overlap

ChIP WA01_KDM2B_KO GSE104690.BCOR.WA01_KDM2B_KO 551 bp overlap

ChIP WA01_RNF2-R_Doxycyclin GSE104690.BCOR.WA01_RNF2-R_Doxycyclin 217 bp overlap

ChIP A-549 ENCSR616MOB.CBX8.A-549 501 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 374 bp overlap

EP300 1 dataset

ChIP osteoblast ENCSR000AUD.EP300.osteoblast 245 bp overlap

EZH2 5 datasets

ChIP A-1847 GSE95643.EZH2.A-1847 128 bp overlap

ChIP DND41 ENCSR000ASW.EZH2.DND41 96 bp overlap

ChIP SF8628 GSE94834.EZH2.SF8628 231 bp overlap

ChIP WA01 ENCSR000ASY.EZH2.WA01 584 bp overlap

ChIP keratinocyte ENCFF070STK 140 bp overlap

EZH2_phosphoT487 2 datasets

ChIP hepatocyte ENCSR341VYI.EZH2_phosphoT487.hepatocyte 203 bp overlap

ChIP neural_progenitor ENCSR656MXA.EZH2_phosphoT487.neural_progenitor 584 bp overlap

FOXA1 2 datasets

ChIP LNCaP_FENG_shFOXA1_Ethanol GSE128883.FOXA1.LNCaP_FENG_shFOXA1_Ethanol 219 bp overlap

ChIP PDAC_KOKLF5 GSE64557.FOXA1.PDAC_KOKLF5 77 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 523 bp overlap

ChIP DE DE-FOXA2-2 502 bp overlap

FOXP1 1 dataset

ChIP H9 GSE31006.FOXP1.H9 326 bp overlap

FOXP4 1 dataset

ChIP WTC11 ENCFF708TAF 377 bp overlap

GATA2 1 dataset

ChIP endothelial_umbilical-vein ENCSR000EVW.GATA2.endothelial_umbilical-vein 206 bp overlap

GATA4 2 datasets

ChIP DE DE-GATA4-1 443 bp overlap

ChIP DE DE-GATA4-2 584 bp overlap

GATA6 10 datasets

ChIP DE DE-GATA6-1 429 bp overlap

ChIP DE DE-GATA6-2 549 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 548 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 575 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 533 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 507 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 584 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 575 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 285 bp overlap

ChIP foregut_KO GSE117136.GATA6.foregut_KO 417 bp overlap

GLIS1 2 datasets

ChIP HEK293 ENCFF299RSE 231 bp overlap

ChIP HEK293 ENCSR482BBZ.GLIS1.HEK293 312 bp overlap

GRHL2 2 datasets

Motif DE_12h DE_12h-GRHL2_MA1105.3 8 bp overlap

Motif DE_36h DE_36h-GRHL2_MA1105.3 8 bp overlap

HNF4A 1 dataset

Motif DE_12h DE_12h-HNF4A_MA0114.5 9 bp overlap

HNF4G 1 dataset

Motif DE_12h DE_12h-HNF4G_MA0484.3 9 bp overlap

HOXC13 2 datasets

Motif DE_12h DE_12h-HOXC13_MA0907.2 9 bp overlap

Motif DE_36h DE_36h-HOXC13_MA0907.2 9 bp overlap

ChIP DE_D1 S08-DE-d1-JUN-exp1 536 bp overlap

ChIP DE_D1 S40-DE-d1-JUN-exp2 530 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 396 bp overlap

ChIP ESC S24-ESC-d0-JUN-exp1 371 bp overlap

ChIP HUES-8 GSE109524.JUN.HUES-8 332 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 573 bp overlap

ChIP endothelial cell of umbilical vein ENCFF791BMV 297 bp overlap

ChIP endothelial_umbilical-vein ENCSR000EFA.JUN.endothelial_umbilical-vein 188 bp overlap

MEIS1 1 dataset

Motif DE_12h DE_12h-MEIS1_MA0498.3 5 bp overlap

MORC2 1 dataset

ChIP H9 GSE95374.MORC2.H9 274 bp overlap

NANOG 11 datasets

ChIP GM23338 ENCFF065NZG 311 bp overlap

ChIP GM23338 ENCSR061DGF.NANOG.GM23338 188 bp overlap

ChIP H1 ENCFF747ZPQ 241 bp overlap

ChIP HUES-8 GSE109524.NANOG.HUES-8 584 bp overlap

ChIP WA01 ENCSR000BMT.NANOG.WA01 291 bp overlap

ChIP WA01 ERP004238.NANOG.WA01 241 bp overlap

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 584 bp overlap

ChIP WA09 GSE105028.NANOG.WA09 554 bp overlap

ChIP WA09_heat-shock GSE105028.NANOG.WA09_heat-shock 572 bp overlap

ChIP hESC GSE20650.NANOG.hESC 292 bp overlap

ChIP hESC GSE18292.NANOG.hESC 245 bp overlap

NFKB1 1 dataset

Motif DE_12h DE_12h-NFKB1_MA0105.4 13 bp overlap

NIPBL 4 datasets

ChIP WA09 GSE105028.NIPBL.WA09 303 bp overlap

ChIP hESC_WNT3A GSE64758.NIPBL.hESC_WNT3A 350 bp overlap

ChIP hESC_WNT3A_ACTIVIN GSE64758.NIPBL.hESC_WNT3A_ACTIVIN 394 bp overlap

ChIP hESC_activin GSE64758.NIPBL.hESC_activin 230 bp overlap

NR2F1 1 dataset

Motif DE_12h DE_12h-NR2F1_MA1537.2 13 bp overlap

Nr2f6 1 dataset

Motif DE_12h DE_12h-Nr2f6_MA0677.2 13 bp overlap

POLR2A 1 dataset

ChIP endothelial cell of umbilical vein ENCFF303XUJ 461 bp overlap

POU5F1 8 datasets

ChIP DE_D1 DED1-OCT4_Batch_II 279 bp overlap

ChIP HUES-8 GSE109524.POU5F1.HUES-8 468 bp overlap

ChIP NCCIT_SNF5 GSE36134.POU5F1.NCCIT_SNF5 489 bp overlap

ChIP WA09 GSE105028.POU5F1.WA09 330 bp overlap

ChIP WA09_heat-shock GSE105028.POU5F1.WA09_heat-shock 366 bp overlap

ChIP hESC_PRIMED GSE69646.POU5F1.hESC_PRIMED 460 bp overlap

ChIP hiPSC GSE56567.POU5F1.hiPSC 221 bp overlap

ChIP hiPSC_3s2 GSE81899.POU5F1.hiPSC_3s2 328 bp overlap

PSIP1 1 dataset

ChIP T-REx-293 GSE117155.PSIP1.T-REx-293 108 bp overlap

ChIP hiPSC_D3 GSE109172.RARA.hiPSC_D3 201 bp overlap

RELA 5 datasets

Motif DE_12h DE_12h-RELA_MA0107.1 10 bp overlap

ChIP HAEC_TNFa_4h GSE89970.RELA.HAEC_TNFa_4h 284 bp overlap

ChIP HUVEC-C_TNF GSE53998.RELA.HUVEC-C_TNF 391 bp overlap

ChIP HUVEC-C_TNF_JQ1 GSE53998.RELA.HUVEC-C_TNF_JQ1 318 bp overlap

ChIP aortic-endothelial-cell_IL1B_D38 GSE139377.RELA.aortic-endothelial-cell_IL1B_D38 272 bp overlap

RNF2 3 datasets

ChIP HUES-64 GSE104059.RNF2.HUES-64 438 bp overlap

ChIP WA01 GSE104690.RNF2.WA01 382 bp overlap

ChIP fibroblast GSE139053.RNF2.fibroblast 406 bp overlap

SMAD2-3 4 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 308 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 426 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 511 bp overlap

ChIP HUVEC-C_TGFB1 GSE134556.SMAD2-3.HUVEC-C_TGFB1 327 bp overlap

SMAD2_3 3 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 511 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 396 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 386 bp overlap

SMAD3 2 datasets

ChIP BG03_DIFF_48H GSE36578.SMAD3.BG03_DIFF_48H 148 bp overlap

ChIP endoderm GSE29422.SMAD3.endoderm 171 bp overlap

SMARCA4 5 datasets

ChIP 501-mel_SHMITF GSE61965.SMARCA4.501-mel_SHMITF 347 bp overlap

ChIP HS-SY-2_HA-tagged GSE108926.SMARCA4.HS-SY-2_HA-tagged 427 bp overlap

ChIP WA09 GSE105028.SMARCA4.WA09 276 bp overlap

ChIP hiPSC GSE124903.SMARCA4.hiPSC 472 bp overlap

ChIP hiPSC_WT GSE124903.SMARCA4.hiPSC_WT 420 bp overlap

SMARCB1 2 datasets

ChIP hiPSC GSE124903.SMARCB1.hiPSC 370 bp overlap

ChIP hiPSC_WT GSE124903.SMARCB1.hiPSC_WT 374 bp overlap

SMARCC1 4 datasets

ChIP DE_D1 S10-DE-d1-BAF155-exp1 325 bp overlap

ChIP DE_D1 S15-DE-d1-BAF155-exp1 332 bp overlap

ChIP hiPSC GSE124903.SMARCC1.hiPSC 419 bp overlap

ChIP hiPSC_WT GSE124903.SMARCC1.hiPSC_WT 344 bp overlap

ChIP HCAEC GSE101921.SMC1.HCAEC 296 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 290 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 350 bp overlap

SOX2 2 datasets

ChIP hESC GSE18292.SOX2.hESC 123 bp overlap

ChIP hiPSC GSE56567.SOX2.hiPSC 415 bp overlap

ChIP H1 ENCFF263FUH 321 bp overlap

ChIP WA01 ENCSR000BIR.SP1.WA01 323 bp overlap

SS18 2 datasets

ChIP Aska-SS_BAF47KO1 GSE108025.SS18.Aska-SS_BAF47KO1 584 bp overlap

ChIP SYO-1 GSE108025.SS18.SYO-1 470 bp overlap

SUZ12 2 datasets

ChIP CRL-7250_shSS18 GSE108025.SUZ12.CRL-7250_shSS18 337 bp overlap

ChIP hiPSC_WT GSE124903.SUZ12.hiPSC_WT 59 bp overlap

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 351 bp overlap

ChIP H9_MESODERM GSE60606.T.H9_MESODERM 333 bp overlap

ChIP PRIMA2 GSE33850.TAL1.PRIMA2 200 bp overlap

TCF12 1 dataset

ChIP WA01 ENCSR000BIT.TCF12.WA01 114 bp overlap

TEAD1 1 dataset

ChIP WTC11 ENCFF502QUV 405 bp overlap

ChIP H9_ectoderm GSE142050.TP53.H9_ectoderm 352 bp overlap

ChIP THP-1_1d_1-25-OH-2D3 GSE89431.VDR.THP-1_1d_1-25-OH-2D3 191 bp overlap

ChIP THP-1_EtOH_1d GSE89431.VDR.THP-1_EtOH_1d 127 bp overlap

ZNF207 1 dataset

ChIP WA09 GSE118632.ZNF207.WA09 237 bp overlap

ZNF35 1 dataset

ChIP HEK293 GSE76494.ZNF35.HEK293 139 bp overlap

ZNF418 1 dataset

Motif DE_12h DE_12h-ZNF418_MA1980.1 15 bp overlap

ZNF701 1 dataset

Motif DE_12h DE_12h-ZNF701_MA1987.2 17 bp overlap

Motif DE_12h DE_12h-Zic2_MA1629.2 9 bp overlap