chr22:50,720,392–50,721,059

chr22 : 50,720,392 – 50,721,059

667 bp 60 TFs 10 linked genes

This 667 bp open chromatin element is linked to 10 target genes and is bound by 60 transcription factors.

Linked Genes

10 genes

Gene	Expression	Dist. to TSS	Distance	Link type
SHANK3		45.6 kb	Distal	Multiome
RABL2B		63.1 kb	Distal	Multiome
RPL23AP7		63.2 kb	Distal	Multiome
ARSA		92.4 kb	Distal	Multiome
CHKB-DT		137.4 kb	Distal	Multiome
CHKB		137.7 kb	Distal	Multiome
SCO2		194.1 kb	Distal	Multiome
NCAPH2		212.3 kb	Distal	Multiome
LMF2		212.8 kb	Distal	Multiome
SBF1		245.5 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

60 transcription factors

BCL11A 2 datasets

ChIP MCF-10A ERP003925.BCL11A.MCF-10A 297 bp overlap

ChIP MCF-10A ERP003925.BCL11A.MCF-10A 124 bp overlap

BCOR 3 datasets

ChIP WA01 GSE104690.BCOR.WA01 496 bp overlap

ChIP WA01 GSE104690.BCOR.WA01 100 bp overlap

ChIP WA01_RNF2-R GSE104690.BCOR.WA01_RNF2-R 667 bp overlap

BRD4 3 datasets

ChIP CLL_patient2_4h_CpG_BET GSE109411.BRD4.CLL_patient2_4h_CpG_BET 189 bp overlap

ChIP T-47D ERP003925.BRD4.T-47D 439 bp overlap

ChIP retina_AB1-FW15 GSE86981.BRD4.retina_AB1-FW15 189 bp overlap

ChIP ME-1 GSE46044.CBFB.ME-1 121 bp overlap

ChIP hMSC GSE117084.CBX4.hMSC 472 bp overlap

ChIP HCT-116 GSE72622.CDK9.HCT-116 51 bp overlap

CTCF 17 datasets

ChIP GM23338 ENCFF772DML 148 bp overlap

ChIP H1 ENCFF230QSV 129 bp overlap

ChIP H1 ENCFF414GZI 192 bp overlap

ChIP H1 ENCFF764RHO 220 bp overlap

ChIP H9 ENCFF152GTF 308 bp overlap

ChIP SH-SY5Y GSE101295.CTCF.SH-SY5Y 109 bp overlap

ChIP WA01 ENCSR000BNH.CTCF.WA01 147 bp overlap

ChIP WA01 ENCSR000DLK.CTCF.WA01 114 bp overlap

ChIP WA01_NEUR GSE52457.CTCF.WA01_NEUR 146 bp overlap

ChIP hiPSC_IB12 GSE106870.CTCF.hiPSC_IB12 205 bp overlap

ChIP hiPSC_IB7 GSE106870.CTCF.hiPSC_IB7 169 bp overlap

ChIP hiPSC_IIA11 GSE106870.CTCF.hiPSC_IIA11 169 bp overlap

ChIP hiPSC_failed-genome-editing GSE106870.CTCF.hiPSC_failed-genome-editing 108 bp overlap

ChIP keratinocyte ENCSR000DWX.CTCF.keratinocyte 129 bp overlap

ChIP neural progenitor cell ENCFF420RBO 260 bp overlap

ChIP neural_progenitor ENCSR125NBL.CTCF.neural_progenitor 248 bp overlap

ChIP neuron_bipolar_doxy_4d ENCSR619IUE.CTCF.neuron_bipolar_doxy_4d 162 bp overlap

CTCFL 1 dataset

ChIP K-562 GSE70764.CTCFL.K-562 198 bp overlap

ChIP NTERA2 GSE58641.DDX5.NTERA2 327 bp overlap

ChIP CD34_NR29 GSE23730.ERG.CD34_NR29 667 bp overlap

ChIP K-562 GSE23730.ERG.K-562 353 bp overlap

ChIP K-562_DOX GSE23730.ERG.K-562_DOX 256 bp overlap

ESR1 2 datasets

ChIP Ishikawa GSE99905.ESR1.Ishikawa 137 bp overlap

ChIP MCF-7_estradiol_45min_ChIP-and-reChIP GSE99626.ESR1.MCF-7_estradiol_45min_ChIP-and-reChIP 85 bp overlap

EZH2 23 datasets

ChIP A-673 ENCSR179SAO.EZH2.A-673 129 bp overlap

ChIP A673 ENCFF790MVL 268 bp overlap

ChIP A673 ENCFF790MVL 502 bp overlap

ChIP A673 ENCFF955JRZ 268 bp overlap

ChIP DU145_SH4 GSE135623.EZH2.DU145_SH4 667 bp overlap

ChIP GM23248 ENCFF404ZHM 532 bp overlap

ChIP GM23248 ENCSR131FFJ.EZH2.GM23248 667 bp overlap

ChIP H1 ENCFF232NZA 667 bp overlap

ChIP LNCaP-abl GSE39459.EZH2.LNCaP-abl 150 bp overlap

ChIP astrocyte ENCFF365JTP 420 bp overlap

ChIP astrocyte ENCFF365JTP 385 bp overlap

ChIP fibroblast of dermis ENCFF029VZK 226 bp overlap

ChIP fibroblast of lung ENCFF479BAW 62 bp overlap

ChIP hESC GSE113817.EZH2.hESC 667 bp overlap

ChIP hESC_KO GSE113817.EZH2.hESC_KO 644 bp overlap

ChIP hepatocyte ENCFF552DZB 65 bp overlap

ChIP keratinocyte ENCFF070STK 406 bp overlap

ChIP keratinocyte ENCSR000ARK.EZH2.keratinocyte 667 bp overlap

ChIP myotube ENCFF857GWB 345 bp overlap

ChIP myotube ENCSR000ASZ.EZH2.myotube 667 bp overlap

ChIP neural progenitor cell ENCFF018MKA 161 bp overlap

ChIP neural progenitor cell ENCFF018MKA 471 bp overlap

ChIP neural progenitor cell ENCFF472NFV 667 bp overlap

FOXA1 1 dataset

ChIP breast-cancer_heregulin-Herceptin-ICI GSE101407.FOXA1.breast-cancer_heregulin-Herceptin-ICI 128 bp overlap

FOXA2 1 dataset

ChIP BJ1-hTERT_FoxHnf1aCoExp GSE90454.FOXA2.BJ1-hTERT_FoxHnf1aCoExp 256 bp overlap

GABPA 3 datasets

ChIP H1 ENCFF739QFD 232 bp overlap

ChIP WA01 ENCSR000BIW.GABPA.WA01 353 bp overlap

ChIP WA01 ENCSR000BIW.GABPA.WA01 226 bp overlap

GLIS3 1 dataset

ChIP H9_plus GSE109562.GLIS3.H9_plus 286 bp overlap

HEXIM1 1 dataset

ChIP HCT-116 GSE72622.HEXIM1.HCT-116 200 bp overlap

HMGB1 1 dataset

ChIP HUVEC-C GSE98245.HMGB1.HUVEC-C 498 bp overlap

HNRNPK 1 dataset

ChIP Hep-G2 GSE120104.HNRNPK.Hep-G2 113 bp overlap

HOXA3 1 dataset

ChIP Hep-G2 ENCSR999JKC.HOXA3.Hep-G2 163 bp overlap

JARID2 4 datasets

ChIP EDOMIPS2 GSE48516.JARID2.EDOMIPS2 606 bp overlap

ChIP MRC-5_IPS25 GSE48516.JARID2.MRC-5_IPS25 618 bp overlap

ChIP UTEIPS6 GSE48516.JARID2.UTEIPS6 667 bp overlap

ChIP UTEIPS7 GSE48516.JARID2.UTEIPS7 667 bp overlap

ChIP HAEC_TNFa_4h GSE89970.JUN.HAEC_TNFa_4h 134 bp overlap

ChIP HAEC_TNFa_4h GSE89970.JUN.HAEC_TNFa_4h 134 bp overlap

KDM4A 7 datasets

ChIP WA01 ENCSR000AVC.KDM4A.WA01 129 bp overlap

ChIP WA01 ENCSR000AVC.KDM4A.WA01 394 bp overlap

ChIP hiPSC_IA12 GSE106870.KDM4A.hiPSC_IA12 183 bp overlap

ChIP hiPSC_IIA11 GSE106870.KDM4A.hiPSC_IIA11 139 bp overlap

ChIP hiPSC_IIA11 GSE106870.KDM4A.hiPSC_IIA11 170 bp overlap

ChIP hiPSC_IID12 GSE106870.KDM4A.hiPSC_IID12 82 bp overlap

ChIP hiPSC_IID12 GSE106870.KDM4A.hiPSC_IID12 334 bp overlap

ChIP keratinocyte GSE140991.KLF3.keratinocyte 354 bp overlap

KMT2A 2 datasets

ChIP MOLM-13_DMSO-D3-180110 GSE127507.KMT2A.MOLM-13_DMSO-D3-180110 117 bp overlap

ChIP MOLM-13_VTP-d3-180110 GSE127507.KMT2A.MOLM-13_VTP-d3-180110 146 bp overlap

MAF1 2 datasets

ChIP THP-1_macrophage_PMA GSE96800.MAF1.THP-1_macrophage_PMA 302 bp overlap

ChIP THP-1_macrophage_PMA GSE96800.MAF1.THP-1_macrophage_PMA 51 bp overlap

MBD2 2 datasets

ChIP HeLa GSE41006.MBD2.HeLa 162 bp overlap

ChIP HeLa GSE41006.MBD2.HeLa 289 bp overlap

MTF2 2 datasets

ChIP DU145_CTR GSE135623.MTF2.DU145_CTR 215 bp overlap

ChIP DU145_SH4 GSE135623.MTF2.DU145_SH4 667 bp overlap

ChIP P493-6_Dpy30-shRNA GSE101853.MYC.P493-6_Dpy30-shRNA 53 bp overlap

ChIP U2OS_SHMYC GSE77356.MYC.U2OS_SHMYC 60 bp overlap

NANOG 1 dataset

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 181 bp overlap

NCAPH2 3 datasets

ChIP HEK293 GSE97540.NCAPH2.HEK293 157 bp overlap

ChIP IMR-90_Bethyl275_OIS GSE118494.NCAPH2.IMR-90_Bethyl275_OIS 322 bp overlap

ChIP IMR-90_FLAG_OIS GSE118494.NCAPH2.IMR-90_FLAG_OIS 239 bp overlap

NR2F2 1 dataset

ChIP MCF-7_E2 GSE132432.NR2F2.MCF-7_E2 667 bp overlap

OGG1 2 datasets

ChIP HEK293_30_min GSE89017.OGG1.HEK293_30_min 80 bp overlap

ChIP HEK293_60_min GSE89017.OGG1.HEK293_60_min 102 bp overlap

POLR2A 5 datasets

ChIP endothelial cell of umbilical vein ENCFF303XUJ 378 bp overlap

ChIP spleen ENCFF446ZGT 667 bp overlap

ChIP spleen ENCFF706IUS 192 bp overlap

ChIP spleen ENCFF706IUS 263 bp overlap

ChIP vagina ENCFF384GAB 116 bp overlap

POU5F1 4 datasets

ChIP DE_D1 DED1-OCT4_Batch_II 501 bp overlap

ChIP SKM-1 GSE93706.POU5F1.SKM-1 277 bp overlap

ChIP WA01_3IL ERP004238.POU5F1.WA01_3IL 169 bp overlap

ChIP WA01_3IL ERP004238.POU5F1.WA01_3IL 171 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 667 bp overlap

RAD21 1 dataset

ChIP hiPSC_failed-genome-editing GSE106870.RAD21.hiPSC_failed-genome-editing 190 bp overlap

RBBP5 1 dataset

ChIP WA01 ENCSR000AQC.RBBP5.WA01 439 bp overlap

RNF2 4 datasets

ChIP WA01 ENCSR784VUY.RNF2.WA01 287 bp overlap

ChIP WA01 GSE104690.RNF2.WA01 339 bp overlap

ChIP WA09 GSE105028.RNF2.WA09 450 bp overlap

ChIP WA09_heat-shock GSE105028.RNF2.WA09_heat-shock 465 bp overlap

ChIP WA01 GSE104690.RYBP.WA01 667 bp overlap

SIN3A 2 datasets

ChIP hiPSC_IB12 GSE106870.SIN3A.hiPSC_IB12 262 bp overlap

ChIP hiPSC_IID12 GSE106870.SIN3A.hiPSC_IID12 95 bp overlap

SIRT6 1 dataset

ChIP SK-MEL-239_L-C-B GSE102813.SIRT6.SK-MEL-239_L-C-B 667 bp overlap

SMAD2-3 1 dataset

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 495 bp overlap

SMARCC1 3 datasets

ChIP Aska-SS GSE108025.SMARCC1.Aska-SS 304 bp overlap

ChIP Aska-SS GSE108025.SMARCC1.Aska-SS 249 bp overlap

ChIP hiPSC GSE124903.SMARCC1.hiPSC 129 bp overlap

SMC1 2 datasets

ChIP DKO GSE131606.SMC1.DKO 111 bp overlap

ChIP IMR-90_OIS GSE118494.SMC1.IMR-90_OIS 255 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 232 bp overlap

ChIP Aska-SS GSE108025.SS18.Aska-SS 113 bp overlap

STAT1_pS727 1 dataset

ChIP SET-2 GSE100566.STAT1_pS727.SET-2 411 bp overlap

STAT3 1 dataset

ChIP WA01 ERP004237.STAT3.WA01 164 bp overlap

SUZ12 5 datasets

ChIP Aska-SS GSE108025.SUZ12.Aska-SS 667 bp overlap

ChIP H1 ENCFF881NFR 667 bp overlap

ChIP NT2-D1 ENCSR000EXH.SUZ12.NT2-D1 667 bp overlap

ChIP NT2-D1 GSE101538.SUZ12.NT2-D1 313 bp overlap

ChIP WA01 ENCSR000ATS.SUZ12.WA01 667 bp overlap

ChIP ME-1 GSE46044.TAL1.ME-1 79 bp overlap

TCF12 1 dataset

ChIP ME-1 GSE46044.TCF12.ME-1 228 bp overlap

TFAP2C 2 datasets

ChIP UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc 265 bp overlap

ChIP UCLA1-hESCs_TFAP2C--_2d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_2d_TFAP2C_Induc 202 bp overlap

ChIP keratinocyte_diff GSE33571.TP63.keratinocyte_diff 182 bp overlap

TRIM24 2 datasets

ChIP LNCaP-abl_ETOH GSE69331.TRIM24.LNCaP-abl_ETOH 95 bp overlap

ChIP LNCaP-abl_ETOH GSE69331.TRIM24.LNCaP-abl_ETOH 286 bp overlap

TRIM25 2 datasets

ChIP BT-549 GSE79588.TRIM25.BT-549 410 bp overlap

ChIP BT-549 GSE79588.TRIM25.BT-549 151 bp overlap

TRIM28 1 dataset

ChIP HCT-116 GSE72622.TRIM28.HCT-116 131 bp overlap

ChIP SMMC-7721 GSE126982.WDR5.SMMC-7721 173 bp overlap

ZNF30 1 dataset

ChIP HEK293T GSE78099.ZNF30.HEK293T 222 bp overlap

ZNF445 1 dataset

ChIP HEK293T GSE78099.ZNF445.HEK293T 667 bp overlap