Transcription factors with Perturb-seq knockdown data for RPL23AP7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPL23AP7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPL23AP7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:50,506,343–50,508,710 | 275.7 kb | Distal (>10kb) Multiome | 856 | |
| chr22:50,524,965–50,527,480 | 256.6 kb | Distal (>10kb) Multiome | 1031 | |
| chr22:50,529,065–50,532,692 | 252.8 kb | Distal (>10kb) Multiome | 745 | |
| chr22:50,562,609–50,563,508 | 220.8 kb | Distal (>10kb) Multiome | 680 | |
| chr22:50,582,134–50,583,431 | 200.8 kb | Distal (>10kb) Multiome | 871 | |
| chr22:50,627,527–50,628,705 | 155.6 kb | Distal (>10kb) Multiome | 685 | |
| chr22:50,674,352–50,675,344 | 108.7 kb | Distal (>10kb) Multiome | 386 | |
| chr22:50,696,725–50,697,564 | 86.3 kb | Distal (>10kb) Multiome | 184 | |
| chr22:50,720,392–50,721,059 | 63.2 kb | Distal (>10kb) Multiome | 60 | |
| chr22:50,775,176–50,775,482 | 8.3 kb | Proximal (<10kb) | 50 | |
| chr22:50,783,521–50,783,856 | at TSS | At TSS | 231 | |
| chr22:50,785,300–50,785,530 | 1.6 kb | Proximal (<10kb) | 6 |
Genomic view of the RPL23AP7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.