chr18 : 24,923,951 – 24,924,675

724 bp 86 TFs 1 linked gene

This 724 bp open chromatin element is linked to ENSG00000266573 and is bound by 86 transcription factors.

Linked Genes

1 gene

Gene	Expression	Dist. to TSS	Distance	Link type
ENSG00000266573		198.4 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

86 transcription factors

ALX3 1 dataset

Motif DE_48h DE_48h-ALX3_MA0634.2 6 bp overlap

BCOR 1 dataset

ChIP WA01_RNF2-R GSE104690.BCOR.WA01_RNF2-R 168 bp overlap

BRD3 1 dataset

ChIP H-1_DE GSE126661.BRD3.H-1_DE 330 bp overlap

BRD4 6 datasets

ChIP CLL_patient2_4h_CpG GSE109411.BRD4.CLL_patient2_4h_CpG 216 bp overlap

ChIP CLL_patient3 GSE109411.BRD4.CLL_patient3 684 bp overlap

ChIP CLL_patient4_4h_CpG GSE109411.BRD4.CLL_patient4_4h_CpG 442 bp overlap

ChIP Kelly_resistant GSE103030.BRD4.Kelly_resistant 200 bp overlap

ChIP Kelly_resistant_JQ1 GSE103030.BRD4.Kelly_resistant_JQ1 218 bp overlap

ChIP Kelly_sensitive GSE103030.BRD4.Kelly_sensitive 129 bp overlap

Cebpa 1 dataset

ChIP BLaER1 ENCFF364PUR 199 bp overlap

DRGX 1 dataset

Motif DE_48h DE_48h-DRGX_MA1481.2 6 bp overlap

EMX1 1 dataset

Motif DE_48h DE_48h-EMX1_MA0612.3 6 bp overlap

EMX2 1 dataset

Motif DE_48h DE_48h-EMX2_MA0886.2 6 bp overlap

EN1 1 dataset

Motif DE_48h DE_48h-EN1_MA0027.3 6 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 221 bp overlap

ETS1 3 datasets

ChIP HUVEC-C_12h GSE93030.ETS1.HUVEC-C_12h 164 bp overlap

ChIP HUVEC-C_VEGF_12H GSE41166.ETS1.HUVEC-C_VEGF_12H 209 bp overlap

ChIP HUVEC-C_VEGF_12h GSE109625.ETS1.HUVEC-C_VEGF_12h 164 bp overlap

EVX1 1 dataset

Motif DE_48h DE_48h-EVX1_MA0887.2 6 bp overlap

EVX2 1 dataset

Motif DE_48h DE_48h-EVX2_MA0888.2 6 bp overlap

EZH2 2 datasets

ChIP PC-9 ENCSR793USK.EZH2.PC-9 99 bp overlap

ChIP SU-DHL-5 GSE45982.EZH2.SU-DHL-5 75 bp overlap

FOXA2 3 datasets

ChIP DE DE-FOXA2-1 649 bp overlap

ChIP DE DE-FOXA2-2 275 bp overlap

ChIP DE DE-FOXA2-2 83 bp overlap

GATA1 2 datasets

ChIP K-562_enCRISPRi-LK GSE132212.GATA1.K-562_enCRISPRi-LK 138 bp overlap

ChIP erythroid-progenitor GSE124163.GATA1.erythroid-progenitor 126 bp overlap

GATA2 4 datasets

ChIP SH-SY5Y ENCFF485YIB 405 bp overlap

ChIP SH-SY5Y ENCSR000EYB.GATA2.SH-SY5Y 213 bp overlap

ChIP hiPSC_SLC6ebs GSE107639.GATA2.hiPSC_SLC6ebs 240 bp overlap

ChIP hiPSC_SLC9ebs GSE107639.GATA2.hiPSC_SLC9ebs 189 bp overlap

GATA3 2 datasets

ChIP Kelly GSE94822.GATA3.Kelly 166 bp overlap

ChIP Kelly GSE65664.GATA3.Kelly 161 bp overlap

GATA3_Nter 1 dataset

ChIP T-47D_CR3flp GSE99479.GATA3_Nter.T-47D_CR3flp 184 bp overlap

GATA4 2 datasets

ChIP DE DE-GATA4-1 710 bp overlap

ChIP DE DE-GATA4-2 724 bp overlap

GATA6 9 datasets

ChIP DE DE-GATA6-1 607 bp overlap

ChIP DE DE-GATA6-2 669 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 724 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 655 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 724 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 724 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 724 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 724 bp overlap

ChIP foregut_KO GSE117136.GATA6.foregut_KO 373 bp overlap

GSX1 1 dataset

Motif DE_48h DE_48h-GSX1_MA0892.2 6 bp overlap

GSX2 1 dataset

Motif DE_48h DE_48h-GSX2_MA0893.3 7 bp overlap

HAND2 2 datasets

ChIP CLB-Ga GSE90683.HAND2.CLB-Ga 430 bp overlap

ChIP Kelly GSE94822.HAND2.Kelly 187 bp overlap

HDAC2 2 datasets

ChIP H1 ENCFF939VKA 237 bp overlap

ChIP WA01 ENCSR000AVB.HDAC2.WA01 139 bp overlap

HOXA1 1 dataset

Motif DE_48h DE_48h-HOXA1_MA1495.2 6 bp overlap

HOXA2 1 dataset

Motif DE_48h DE_48h-HOXA2_MA0900.3 6 bp overlap

HOXA3 1 dataset

Motif DE_48h DE_48h-HOXA3_MA2119.1 7 bp overlap

HOXA5 1 dataset

Motif DE_48h DE_48h-HOXA5_MA0158.2 8 bp overlap

HOXA6 1 dataset

Motif DE_48h DE_48h-HOXA6_MA1497.2 7 bp overlap

HOXB1 1 dataset

Motif DE_48h DE_48h-HOXB1_MA2093.1 7 bp overlap

HOXB2 1 dataset

Motif DE_48h DE_48h-HOXB2_MA0902.3 6 bp overlap

HOXB3 1 dataset

Motif DE_48h DE_48h-HOXB3_MA0903.2 6 bp overlap

HOXB5 1 dataset

Motif DE_48h DE_48h-HOXB5_MA0904.3 6 bp overlap

HOXB6 1 dataset

Motif DE_48h DE_48h-HOXB6_MA1500.2 7 bp overlap

HOXB7 1 dataset

Motif DE_48h DE_48h-HOXB7_MA1501.2 7 bp overlap

HOXB8 1 dataset

Motif DE_48h DE_48h-HOXB8_MA1502.2 7 bp overlap

HOXC8 1 dataset

Motif DE_48h DE_48h-HOXC8_MA1505.2 6 bp overlap

HOXD8 1 dataset

Motif DE_48h DE_48h-HOXD8_MA0910.3 7 bp overlap

ISX 1 dataset

Motif DE_48h DE_48h-ISX_MA0654.2 6 bp overlap

JUN 2 datasets

ChIP DE_D2 S02-DE-d2-JUN-exp1 393 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 293 bp overlap

LHX5 1 dataset

Motif DE_48h DE_48h-LHX5_MA1519.2 7 bp overlap

Lhx4 1 dataset

Motif DE_48h DE_48h-Lhx4_MA0704.2 6 bp overlap

Lhx8 1 dataset

Motif DE_48h DE_48h-Lhx8_MA0705.2 6 bp overlap

MED1 1 dataset

ChIP RH4 GSE83726.MED1.RH4 217 bp overlap

MEOX1 1 dataset

Motif DE_48h DE_48h-MEOX1_MA0661.2 7 bp overlap

MEOX2 1 dataset

Motif DE_48h DE_48h-MEOX2_MA0706.2 7 bp overlap

MITF 3 datasets

ChIP 501-mel GSE137522.MITF.501-mel 373 bp overlap

ChIP 501-mel GSE61965.MITF.501-mel 216 bp overlap

ChIP 501-mel_K243Q GSE137522.MITF.501-mel_K243Q 303 bp overlap

MIXL1 1 dataset

Motif DE_48h DE_48h-MIXL1_MA0662.2 6 bp overlap

MNX1 1 dataset

Motif DE_48h DE_48h-MNX1_MA0707.3 6 bp overlap

NANOG 10 datasets

ChIP GM23338 ENCSR061DGF.NANOG.GM23338 126 bp overlap

ChIP H1 ENCFF747ZPQ 137 bp overlap

ChIP HUES-8 GSE109524.NANOG.HUES-8 540 bp overlap

ChIP WA01 ERP004238.NANOG.WA01 364 bp overlap

ChIP WA01 ENCSR000BMT.NANOG.WA01 238 bp overlap

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 667 bp overlap

ChIP WA09 GSE105028.NANOG.WA09 362 bp overlap

ChIP WA09_heat-shock GSE105028.NANOG.WA09_heat-shock 302 bp overlap

ChIP hESC GSE20650.NANOG.hESC 185 bp overlap

ChIP hESC GSE18292.NANOG.hESC 115 bp overlap

NCOA3 1 dataset

ChIP MCF-7_E2 ERP000901.NCOA3.MCF-7_E2 141 bp overlap

NKX6-2 1 dataset

Motif DE_48h DE_48h-NKX6-2_MA0675.2 6 bp overlap

PAX3 1 dataset

Motif DE_48h DE_48h-PAX3_MA1546.2 14 bp overlap

PDX1 1 dataset

Motif DE_48h DE_48h-PDX1_MA0132.3 6 bp overlap

POU5F1 3 datasets

ChIP DE_D1 DED1-OCT4_Batch_II 269 bp overlap

ChIP HUES-8 GSE109524.POU5F1.HUES-8 262 bp overlap

ChIP hESC_PRIMED GSE69646.POU5F1.hESC_PRIMED 268 bp overlap

POU6F1 1 dataset

Motif DE_48h DE_48h-POU6F1_MA0628.2 6 bp overlap

PPARG 1 dataset

ChIP HUVEC-C_DMSO_HYPO GSE50144.PPARG.HUVEC-C_DMSO_HYPO 156 bp overlap

PRRX1 1 dataset

Motif DE_48h DE_48h-PRRX1_MA0716.2 6 bp overlap

RARA 2 datasets

ChIP hiPSC_D3 GSE109172.RARA.hiPSC_D3 354 bp overlap

ChIP hiPSC_D4 GSE109172.RARA.hiPSC_D4 337 bp overlap

RAX2 1 dataset

Motif DE_48h DE_48h-RAX2_MA0717.2 6 bp overlap

SHOX 1 dataset

Motif DE_48h DE_48h-SHOX_MA0630.2 6 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 566 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 724 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 645 bp overlap

SMAD2_3 6 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 476 bp overlap

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 104 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 556 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 599 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 548 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 380 bp overlap

SMAD3 1 dataset

ChIP BG03_DIFF_48H GSE36578.SMAD3.BG03_DIFF_48H 184 bp overlap

SMARCA4 1 dataset

ChIP hiPSC GSE124903.SMARCA4.hiPSC 238 bp overlap

SMARCB1 1 dataset

ChIP hiPSC GSE124903.SMARCB1.hiPSC 232 bp overlap

SMARCC1 2 datasets

ChIP DE_D1 S15-DE-d1-BAF155-exp1 394 bp overlap

ChIP hiPSC GSE124903.SMARCC1.hiPSC 255 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 571 bp overlap

SOX2 1 dataset

ChIP hiPSC GSE56567.SOX2.hiPSC 310 bp overlap

STAT5A 1 dataset

ChIP MV4-11 GSE64862.STAT5A.MV4-11 91 bp overlap

Shox2 1 dataset

Motif DE_48h DE_48h-Shox2_MA0720.2 6 bp overlap

T 2 datasets

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 266 bp overlap

ChIP H9_MESODERM GSE60606.T.H9_MESODERM 238 bp overlap

TLX2 1 dataset

Motif DE_48h DE_48h-TLX2_MA1577.2 6 bp overlap

UNCX 1 dataset

Motif DE_48h DE_48h-UNCX_MA0721.2 6 bp overlap

VAX2 1 dataset

Motif DE_48h DE_48h-VAX2_MA0723.3 6 bp overlap

ZBTB6 1 dataset

Motif DE_48h DE_48h-ZBTB6_MA1581.2 9 bp overlap

ZIC1 1 dataset

Motif DE_48h DE_48h-ZIC1_MA0696.1 14 bp overlap

ZIC4 1 dataset

Motif DE_48h DE_48h-ZIC4_MA0751.2 14 bp overlap

ZIC5 1 dataset

Motif DE_48h DE_48h-ZIC5_MA1584.2 15 bp overlap

ZNF423 1 dataset

ChIP WTC11 ENCFF574PBR 317 bp overlap

ZNF454 1 dataset

Motif DE_48h DE_48h-ZNF454_MA1712.2 17 bp overlap

ZNF549 1 dataset

Motif DE_48h DE_48h-ZNF549_MA1728.2 8 bp overlap

ZNF573 1 dataset

ChIP HEK293T GSE78099.ZNF573.HEK293T 304 bp overlap

ZNF768 1 dataset

Motif DE_48h DE_48h-ZNF768_MA1731.2 9 bp overlap

Zic2 1 dataset

Motif DE_48h DE_48h-Zic2_MA1629.2 9 bp overlap