Transcription factors with Perturb-seq knockdown data for ENSG00000266573. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000266573 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000266573, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:24,426,310–24,427,225 | 299.2 kb | Distal (>10kb) Multiome | 799 | |
| chr18:24,726,751–24,726,965 | 889 bp | At TSS | 142 | |
| chr18:24,923,951–24,924,675 | 198.4 kb | Distal (>10kb) Multiome | 86 | |
| chr18:24,979,051–24,979,672 | 253.5 kb | Distal (>10kb) Multiome | 88 | |
| chr18:25,019,158–25,020,320 | 294.0 kb | Distal (>10kb) Multiome | 217 |
Genomic view of the ENSG00000266573 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.