chr10:5,697,995–5,698,400

chr10 : 5,697,995 – 5,698,400

405 bp 69 TFs 6 linked genes

This 405 bp open chromatin element is linked to 6 target genes and is bound by 69 transcription factors.

Linked Genes

6 genes

Gene	Expression	Dist. to TSS	Distance	Link type
TASOR2		5.2 kb	Proximal	Proximity
ASB13		31.5 kb	Distal	Multiome
GDI2		115.3 kb	Distal	Multiome
ANKRD16		191.8 kb	Distal	Multiome
FBH1		192.1 kb	Distal	Multiome
NET1		251.5 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

69 transcription factors

Arid3a 2 datasets

Motif DE_60h DE_60h-Arid3a_MA0151.1 6 bp overlap

Motif DE_72h DE_72h-Arid3a_MA0151.1 6 bp overlap

BHLHE22 2 datasets

Motif DE_48h DE_48h-BHLHE22_MA1635.2 6 bp overlap

Motif DE_60h DE_60h-BHLHE22_MA1635.2 6 bp overlap

CEBPA 7 datasets

ChIP Hep-G2 ERP000209.CEBPA.Hep-G2 73 bp overlap

ChIP HepG2 ENCFF175DFS 160 bp overlap

ChIP Kasumi-1_CEBPA-ER GSE102697.CEBPA.Kasumi-1_CEBPA-ER 112 bp overlap

ChIP T-47D_progesterone GSE132649.CEBPA.T-47D_progesterone 191 bp overlap

ChIP THP-1_1-25D_2h GSE124032.CEBPA.THP-1_1-25D_2h 154 bp overlap

ChIP THP-1_EtOH_24h GSE124032.CEBPA.THP-1_EtOH_24h 140 bp overlap

ChIP THP-1_EtOH_2h GSE124032.CEBPA.THP-1_EtOH_2h 151 bp overlap

CEBPB 7 datasets

ChIP H1 ENCFF871PTR 160 bp overlap

ChIP HepG2 ENCFF536NTI 115 bp overlap

ChIP K-562 ENCSR000EHE.CEBPB.K-562 92 bp overlap

ChIP K-562 ENCSR000BRQ.CEBPB.K-562 95 bp overlap

ChIP K562 ENCFF189VBN 150 bp overlap

ChIP K562 ENCFF194QGF 161 bp overlap

ChIP K562 ENCFF584CTB 269 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 386 bp overlap

FOXA2 3 datasets

ChIP DE DE-FOXA2-1 405 bp overlap

ChIP DE DE-FOXA2-2 405 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.FOXA2.pancreatic-progenitor_PP1 172 bp overlap

FOXD3 3 datasets

Motif DE_48h DE_48h-FOXD3_MA0041.3 14 bp overlap

Motif DE_60h DE_60h-FOXD3_MA0041.3 14 bp overlap

Motif DE_72h DE_72h-FOXD3_MA0041.3 14 bp overlap

FOXO1::FLI1 2 datasets

Motif DE_60h DE_60h-FOXO1FLI1_MA1956.2 13 bp overlap

Motif DE_72h DE_72h-FOXO1FLI1_MA1956.2 13 bp overlap

GATA1 4 datasets

ChIP CD34_Day7_30min GSE104676.GATA1.CD34_Day7_30min 77 bp overlap

ChIP K-562_enCRISPRi-LK GSE132212.GATA1.K-562_enCRISPRi-LK 179 bp overlap

ChIP erythroblast ENCSR000EXP.GATA1.erythroblast 354 bp overlap

ChIP erythroid_Don001 GSE137982.GATA1.erythroid_Don001 229 bp overlap

GATA2 6 datasets

ChIP SH-SY5Y ENCFF485YIB 305 bp overlap

ChIP SH-SY5Y ENCSR000EYB.GATA2.SH-SY5Y 333 bp overlap

ChIP SK-N-SH ENCFF764OZD 318 bp overlap

ChIP TF1 GSE73207.GATA2.TF1 331 bp overlap

ChIP dermal-fibroblast GSE51025.GATA2.dermal-fibroblast 177 bp overlap

ChIP dermal-fibroblast_alone GSE51025.GATA2.dermal-fibroblast_alone 204 bp overlap

GATA3 6 datasets

ChIP BE2C GSE65664.GATA3.BE2C 157 bp overlap

ChIP CLB-Ga GSE90683.GATA3.CLB-Ga 193 bp overlap

ChIP Jurkat GSE76181.GATA3.Jurkat 163 bp overlap

ChIP SH-SY5Y ENCFF475HYF 340 bp overlap

ChIP SH-SY5Y ENCSR000EXZ.GATA3.SH-SY5Y 320 bp overlap

ChIP T-47D GSE51274.GATA3.T-47D 161 bp overlap

GATA3_Nter 1 dataset

ChIP T-47D_CR3flp GSE99479.GATA3_Nter.T-47D_CR3flp 177 bp overlap

GATA4 7 datasets

ChIP BJ1-hTERT_FOXA2_GATA4_Coexp GSE92491.GATA4.BJ1-hTERT_FOXA2_GATA4_Coexp 233 bp overlap

ChIP DE DE-GATA4-1 405 bp overlap

ChIP DE DE-GATA4-2 405 bp overlap

ChIP Hep-G2 GSE135714.GATA4.Hep-G2 342 bp overlap

ChIP foregut GSE117136.GATA4.foregut 397 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 405 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 340 bp overlap

GATA6 11 datasets

ChIP DE DE-GATA6-1 405 bp overlap

ChIP DE DE-GATA6-2 405 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 401 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 405 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 405 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 405 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 401 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 405 bp overlap

ChIP foregut GSE117136.GATA6.foregut 404 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA6.pancreatic-progenitor 328 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA6.pancreatic-progenitor_PP1 311 bp overlap

GRHL2 1 dataset

ChIP LNCaP GSE80256.GRHL2.LNCaP 198 bp overlap

HOXB13 3 datasets

Motif DE_48h DE_48h-HOXB13_MA0901.3 9 bp overlap

Motif DE_60h DE_60h-HOXB13_MA0901.3 9 bp overlap

Motif DE_72h DE_72h-HOXB13_MA0901.3 9 bp overlap

HOXB4 2 datasets

Motif DE_60h DE_60h-HOXB4_MA1499.2 6 bp overlap

Motif DE_72h DE_72h-HOXB4_MA1499.2 6 bp overlap

HOXC4 2 datasets

Motif DE_60h DE_60h-HOXC4_MA1504.2 6 bp overlap

Motif DE_72h DE_72h-HOXC4_MA1504.2 6 bp overlap

HOXD4 2 datasets

Motif DE_60h DE_60h-HOXD4_MA1507.2 6 bp overlap

Motif DE_72h DE_72h-HOXD4_MA1507.2 6 bp overlap

Hmga1 3 datasets

Motif DE_48h DE_48h-Hmga1_MA2124.1 8 bp overlap

Motif DE_60h DE_60h-Hmga1_MA2124.1 8 bp overlap

Motif DE_72h DE_72h-Hmga1_MA2124.1 8 bp overlap

Hoxa13 3 datasets

Motif DE_48h DE_48h-Hoxa13_MA0650.4 8 bp overlap

Motif DE_60h DE_60h-Hoxa13_MA0650.4 8 bp overlap

Motif DE_72h DE_72h-Hoxa13_MA0650.4 8 bp overlap

Irf1 8 datasets

Motif DE_36h DE_36h-Irf1_MA0050.4 11 bp overlap

Motif DE_36h DE_36h-Irf1_MA0050.4 11 bp overlap

Motif DE_48h DE_48h-Irf1_MA0050.4 11 bp overlap

Motif DE_48h DE_48h-Irf1_MA0050.4 11 bp overlap

Motif DE_60h DE_60h-Irf1_MA0050.4 11 bp overlap

Motif DE_60h DE_60h-Irf1_MA0050.4 11 bp overlap

Motif DE_72h DE_72h-Irf1_MA0050.4 11 bp overlap

Motif DE_72h DE_72h-Irf1_MA0050.4 11 bp overlap

Lef1 2 datasets

Motif DE_60h DE_60h-Lef1_MA0768.3 8 bp overlap

Motif DE_72h DE_72h-Lef1_MA0768.3 8 bp overlap

MEF2A 3 datasets

Motif DE_48h DE_48h-MEF2A_MA0052.5 10 bp overlap

Motif DE_60h DE_60h-MEF2A_MA0052.5 10 bp overlap

Motif DE_72h DE_72h-MEF2A_MA0052.5 10 bp overlap

MEF2B 3 datasets

Motif DE_48h DE_48h-MEF2B_MA0660.1 12 bp overlap

Motif DE_60h DE_60h-MEF2B_MA0660.1 12 bp overlap

Motif DE_72h DE_72h-MEF2B_MA0660.1 12 bp overlap

MEF2C 3 datasets

Motif DE_48h DE_48h-MEF2C_MA0497.2 11 bp overlap

Motif DE_60h DE_60h-MEF2C_MA0497.2 11 bp overlap

Motif DE_72h DE_72h-MEF2C_MA0497.2 11 bp overlap

MEF2D 3 datasets

Motif DE_48h DE_48h-MEF2D_MA0773.1 12 bp overlap

Motif DE_60h DE_60h-MEF2D_MA0773.1 12 bp overlap

Motif DE_72h DE_72h-MEF2D_MA0773.1 12 bp overlap

MEIS1 2 datasets

Motif DE_60h DE_60h-MEIS1_MA0498.3 5 bp overlap

Motif DE_72h DE_72h-MEIS1_MA0498.3 5 bp overlap

ChIP K562 ENCFF820IGH 331 bp overlap

ChIP K562 ENCFF820IGH 405 bp overlap

NANOG 4 datasets

ChIP HUES-8 GSE109524.NANOG.HUES-8 290 bp overlap

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 303 bp overlap

ChIP WA09 GSE105028.NANOG.WA09 199 bp overlap

ChIP hESC GSE18292.NANOG.hESC 93 bp overlap

NFATC3 3 datasets

Motif DE_48h DE_48h-NFATC3_MA0625.3 6 bp overlap

Motif DE_60h DE_60h-NFATC3_MA0625.3 6 bp overlap

Motif DE_72h DE_72h-NFATC3_MA0625.3 6 bp overlap

NFYA 4 datasets

Motif DE_48h DE_48h-NFYA_MA0060.4 8 bp overlap

Motif DE_60h DE_60h-NFYA_MA0060.4 8 bp overlap

Motif DE_72h DE_72h-NFYA_MA0060.4 8 bp overlap

ChIP K-562 GSE26439.NFYA.K-562 249 bp overlap

NFYB 3 datasets

ChIP K-562 GSE26439.NFYB.K-562 312 bp overlap

ChIP K-562 ENCSR000EGQ.NFYB.K-562 181 bp overlap

ChIP K562 ENCFF709RXX 301 bp overlap

NKX3-1 1 dataset

ChIP islet ERP004003.NKX3-1.islet 155 bp overlap

NKX6-1 2 datasets

Motif DE_60h DE_60h-NKX6-1_MA0674.2 7 bp overlap

Motif DE_72h DE_72h-NKX6-1_MA0674.2 7 bp overlap

NUP98-HOXA9 1 dataset

ChIP HEK293-FT GSE62586.NUP98-HOXA9.HEK293-FT 226 bp overlap

Neurod2 2 datasets

Motif DE_48h DE_48h-Neurod2_MA1993.2 6 bp overlap

Motif DE_60h DE_60h-Neurod2_MA1993.2 6 bp overlap

Nfatc1 3 datasets

Motif DE_48h DE_48h-Nfatc1_MA0624.3 6 bp overlap

Motif DE_60h DE_60h-Nfatc1_MA0624.3 6 bp overlap

Motif DE_72h DE_72h-Nfatc1_MA0624.3 6 bp overlap

Nfatc2 3 datasets

Motif DE_48h DE_48h-Nfatc2_MA0152.3 8 bp overlap

Motif DE_60h DE_60h-Nfatc2_MA0152.3 8 bp overlap

Motif DE_72h DE_72h-Nfatc2_MA0152.3 8 bp overlap

Nfe2l2 3 datasets

Motif DE_48h DE_48h-Nfe2l2_MA0150.3 11 bp overlap

Motif DE_60h DE_60h-Nfe2l2_MA0150.3 11 bp overlap

Motif DE_72h DE_72h-Nfe2l2_MA0150.3 11 bp overlap

Olig2 2 datasets

Motif DE_48h DE_48h-Olig2_MA1997.2 6 bp overlap

Motif DE_60h DE_60h-Olig2_MA1997.2 6 bp overlap

PKNOX1 2 datasets

Motif DE_60h DE_60h-PKNOX1_MA0782.3 10 bp overlap

Motif DE_72h DE_72h-PKNOX1_MA0782.3 10 bp overlap

POU2F1::SOX2 3 datasets

Motif DE_48h DE_48h-POU2F1SOX2_MA1962.1 17 bp overlap

Motif DE_60h DE_60h-POU2F1SOX2_MA1962.1 17 bp overlap

Motif DE_72h DE_72h-POU2F1SOX2_MA1962.1 17 bp overlap

POU5F1 1 dataset

ChIP HUES-8 GSE109524.POU5F1.HUES-8 248 bp overlap

PROX1 3 datasets

Motif DE_48h DE_48h-PROX1_MA0794.1 12 bp overlap

Motif DE_60h DE_60h-PROX1_MA0794.1 12 bp overlap

Motif DE_72h DE_72h-PROX1_MA0794.1 12 bp overlap

PSIP1 1 dataset

ChIP T-REx-293 GSE117155.PSIP1.T-REx-293 297 bp overlap

Pou5f1::Sox2 3 datasets

Motif DE_48h DE_48h-Pou5f1Sox2_MA0142.1 15 bp overlap

Motif DE_60h DE_60h-Pou5f1Sox2_MA0142.1 15 bp overlap

Motif DE_72h DE_72h-Pou5f1Sox2_MA0142.1 15 bp overlap

Prdm4 4 datasets

Motif DE_36h DE_36h-Prdm4_MA1647.3 11 bp overlap

Motif DE_48h DE_48h-Prdm4_MA1647.3 11 bp overlap

Motif DE_60h DE_60h-Prdm4_MA1647.3 11 bp overlap

Motif DE_72h DE_72h-Prdm4_MA1647.3 11 bp overlap

SMAD2-3 1 dataset

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 345 bp overlap

SMAD2_3 1 dataset

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 284 bp overlap

SMARCA4 1 dataset

ChIP CTV-1_delA GSE128835.SMARCA4.CTV-1_delA 202 bp overlap

SOX10 2 datasets

Motif DE_60h DE_60h-SOX10_MA0442.3 6 bp overlap

Motif DE_72h DE_72h-SOX10_MA0442.3 6 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 272 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 307 bp overlap

ChIP hiPSC GSE56567.SOX2.hiPSC 185 bp overlap

SPIB 2 datasets

Motif DE_60h DE_60h-SPIB_MA0081.3 13 bp overlap

Motif DE_72h DE_72h-SPIB_MA0081.3 13 bp overlap

Stat2 3 datasets

Motif DE_48h DE_48h-Stat2_MA1623.2 10 bp overlap

Motif DE_60h DE_60h-Stat2_MA1623.2 10 bp overlap

Motif DE_72h DE_72h-Stat2_MA1623.2 10 bp overlap

TP53 4 datasets

Motif DE_48h DE_48h-TP53_MA0106.3 18 bp overlap

Motif DE_60h DE_60h-TP53_MA0106.3 18 bp overlap

Motif DE_72h DE_72h-TP53_MA0106.3 18 bp overlap

ChIP MCF-7_nutlin GSE86164.TP53.MCF-7_nutlin 197 bp overlap

TP63 3 datasets

Motif DE_48h DE_48h-TP63_MA0525.2 18 bp overlap

Motif DE_60h DE_60h-TP63_MA0525.2 18 bp overlap

Motif DE_72h DE_72h-TP63_MA0525.2 18 bp overlap

TP73 3 datasets

Motif DE_48h DE_48h-TP73_MA0861.2 16 bp overlap

Motif DE_60h DE_60h-TP73_MA0861.2 16 bp overlap

Motif DE_72h DE_72h-TP73_MA0861.2 16 bp overlap

Tcf12 2 datasets

Motif DE_48h DE_48h-Tcf12_MA0521.3 6 bp overlap

Motif DE_60h DE_60h-Tcf12_MA0521.3 6 bp overlap

Twist2 2 datasets

Motif DE_48h DE_48h-Twist2_MA0633.3 6 bp overlap

Motif DE_60h DE_60h-Twist2_MA0633.3 6 bp overlap

VEZF1 1 dataset

ChIP K562 ENCFF053XDV 81 bp overlap

ZBTB40 1 dataset

ChIP K-562 ENCSR237VLT.ZBTB40.K-562 92 bp overlap

ZFP64 1 dataset

ChIP HEK293 GSE76494.ZFP64.HEK293 205 bp overlap

ZNF189 3 datasets

Motif DE_60h DE_60h-ZNF189_MA1725.2 9 bp overlap

Motif DE_72h DE_72h-ZNF189_MA1725.2 9 bp overlap

ChIP HEK293 ENCSR163RYW.ZNF189.HEK293 226 bp overlap

ZNF530 2 datasets

Motif DE_48h DE_48h-ZNF530_MA1981.2 14 bp overlap

Motif DE_60h DE_60h-ZNF530_MA1981.2 14 bp overlap

ZNF577 1 dataset

ChIP HEK293 ENCSR776MDR.ZNF577.HEK293 350 bp overlap

ZNF707 2 datasets

Motif DE_60h DE_60h-ZNF707_MA1715.1 15 bp overlap

Motif DE_72h DE_72h-ZNF707_MA1715.1 15 bp overlap