Predicted to be involved in negative regulation of gene expression, epigenetic. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TASOR2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TASOR2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TASOR2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:3,890,598–3,891,428 | 1793.8 kb | Distal (>10kb) Multiome HiCAR | 408 | |
| chr10:4,007,209–4,008,542 | 1676.9 kb | Distal (>10kb) Multiome HiCAR | 100 | |
| chr10:5,412,181–5,413,375 | 272.2 kb | Distal (>10kb) Multiome | 650 | |
| chr10:5,446,256–5,446,879 | 238.3 kb | Distal (>10kb) Multiome | 855 | |
| chr10:5,466,039–5,467,339 | 218.1 kb | Distal (>10kb) Multiome | 493 | |
| chr10:5,472,263–5,472,901 | 212.3 kb | Distal (>10kb) Multiome | 181 | |
| chr10:5,623,013–5,623,598 | 61.5 kb | Distal (>10kb) Multiome | 611 | |
| chr10:5,665,943–5,666,966 | 18.3 kb | Distal (>10kb) Multiome | 720 | |
| chr10:5,684,325–5,685,785 | 157 bp | At TSS Multiome | 1140 | |
| chr10:5,692,454–5,693,306 | 8.0 kb | Proximal (<10kb) Multiome | 757 | |
| chr10:5,697,405–5,697,831 | 4.6 kb | Proximal (<10kb) | 87 | |
| chr10:5,697,995–5,698,400 | 13.3 kb | Distal (>10kb) Multiome | 69 | |
| chr10:5,812,699–5,814,342 | 128.7 kb | Distal (>10kb) Multiome | 1126 | |
| chr10:5,866,673–5,867,954 | 182.5 kb | Distal (>10kb) Multiome | 153 | |
| chr10:5,888,755–5,891,014 | 205.2 kb | Distal (>10kb) Multiome | 918 | |
| chr10:5,976,561–5,978,337 | 293.1 kb | Distal (>10kb) Multiome | 723 |
Genomic view of the TASOR2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.