The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants, both protein-coding and not protein-coding, have been described for this gene. [provided by RefSeq, Nov 2010]
Transcription factors with Perturb-seq knockdown data for ASB13. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ASB13 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ASB13, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:5,412,181–5,413,375 | 254.0 kb | Distal (>10kb) Multiome | 650 | |
| chr10:5,446,256–5,446,879 | 220.0 kb | Distal (>10kb) Multiome | 855 | |
| chr10:5,466,039–5,467,339 | 199.8 kb | Distal (>10kb) Multiome | 493 | |
| chr10:5,472,263–5,472,901 | 194.1 kb | Distal (>10kb) Multiome | 181 | |
| chr10:5,623,013–5,623,598 | 43.3 kb | Distal (>10kb) Multiome | 611 | |
| chr10:5,659,044–5,659,569 | 7.0 kb | Proximal (<10kb) | 319 | |
| chr10:5,665,943–5,666,966 | 14 bp | At TSS Multiome | 720 | |
| chr10:5,684,325–5,685,785 | 18.1 kb | Distal (>10kb) Multiome | 1140 | |
| chr10:5,692,454–5,693,306 | 26.3 kb | Distal (>10kb) Multiome | 757 | |
| chr10:5,697,995–5,698,400 | 31.5 kb | Distal (>10kb) Multiome | 69 | |
| chr10:5,812,699–5,814,342 | 146.9 kb | Distal (>10kb) Multiome | 1126 | |
| chr10:5,866,673–5,867,954 | 200.8 kb | Distal (>10kb) Multiome | 153 | |
| chr10:5,888,755–5,891,014 | 223.5 kb | Distal (>10kb) Multiome | 918 |
Genomic view of the ASB13 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.