GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GDI2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GDI2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GDI2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:5,623,013–5,623,598 | 190.1 kb | Distal (>10kb) Multiome | 611 | |
| chr10:5,665,943–5,666,966 | 146.9 kb | Distal (>10kb) Multiome | 720 | |
| chr10:5,684,325–5,685,785 | 128.8 kb | Distal (>10kb) Multiome | 1140 | |
| chr10:5,692,454–5,693,306 | 120.6 kb | Distal (>10kb) Multiome | 757 | |
| chr10:5,697,995–5,698,400 | 115.3 kb | Distal (>10kb) Multiome | 69 | |
| chr10:5,812,699–5,814,342 | 71 bp | At TSS Multiome | 1126 | |
| chr10:5,866,673–5,867,954 | 53.9 kb | Distal (>10kb) Multiome | 153 | |
| chr10:5,888,755–5,891,014 | 76.6 kb | Distal (>10kb) Multiome | 918 | |
| chr10:5,976,561–5,978,337 | 164.5 kb | Distal (>10kb) Multiome | 723 | |
| chr10:6,086,345–6,087,026 | 273.1 kb | Distal (>10kb) Multiome | 467 | |
| chr10:6,088,532–6,090,276 | 275.5 kb | Distal (>10kb) Multiome | 847 | |
| chr10:6,108,563–6,109,206 | 295.4 kb | Distal (>10kb) Multiome | 207 |
Genomic view of the GDI2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.