chr5 : 135,877,361 135,878,257
896 bp 83 TFs 2 linked genes
This 896 bp open chromatin element is linked to SMAD5 and SLC25A48 and is bound by 83 transcription factors.
Linked Genes
2 genes
Link type
Gene Expression Dist. to TSS Distance Link type
SMAD5 255.1 kb Distal Multiome
SLC25A48 298.6 kb Distal Multiome+HiCAR
Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

View limited to ±500 kb around this element.
For the full data, please see the UCSC track linked below.
chr5:135,872,361 – 135,883,257
This element Other elements Gene links ATAC-seq RNA-seq

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding
83 transcription factors
Source
Cell type
ARID1A 1 dataset
ChIP RMG-I GSE104545.ARID1A.RMG-I 125 bp overlap
ASCL1 1 dataset
ChIP SCLC_ASCLP GSE61197.ASCL1.SCLC_ASCLP 52 bp overlap
BRD4 2 datasets
ChIP Hep-G2 GSE123097.BRD4.Hep-G2 263 bp overlap
ChIP MCF-10A ERP003925.BRD4.MCF-10A 404 bp overlap
CDKN1B 1 dataset
ChIP MDA-MB-231_p27CK-DD GSE112444.CDKN1B.MDA-MB-231_p27CK-DD 82 bp overlap
CTCF 2 datasets
Motif DE_48h DE_48h-CTCF_MA1929.2 31 bp overlap
Motif DE_72h DE_72h-CTCF_MA1929.2 31 bp overlap
Cebpa 1 dataset
ChIP BLaER1 ENCFF031ISE 285 bp overlap
Crx 1 dataset
Motif DE_72h DE_72h-Crx_MA0467.3 6 bp overlap
DPRX 1 dataset
Motif DE_72h DE_72h-DPRX_MA1480.2 9 bp overlap
EOMES 1 dataset
ChIP hESC GSE26097.EOMES.hESC 260 bp overlap
ESR1 4 datasets
ChIP MCF-7_PaPE-1_OA GSE93510.ESR1.MCF-7_PaPE-1_OA 187 bp overlap
ChIP MCF-7_RUNX2_DOX GSE86538.ESR1.MCF-7_RUNX2_DOX 240 bp overlap
ChIP T-47D_Y537S_E2 GSE148277.ESR1.T-47D_Y537S_E2 286 bp overlap
ChIP breast_tumor_Male_10 GSE104399.ESR1.breast_tumor_Male_10 231 bp overlap
ESRRG 1 dataset
ChIP cardiomyocyte GSE113760.ESRRG.cardiomyocyte 239 bp overlap
EZH2 1 dataset
ChIP LNCaP-abl GSE39459.EZH2.LNCaP-abl 239 bp overlap
FOXA2 2 datasets
ChIP DE DE-FOXA2-1 323 bp overlap
ChIP DE DE-FOXA2-2 296 bp overlap
GATA1::TAL1 3 datasets
Motif DE_48h DE_48h-GATA1TAL1_MA0140.3 17 bp overlap
Motif DE_60h DE_60h-GATA1TAL1_MA0140.3 17 bp overlap
Motif DE_72h DE_72h-GATA1TAL1_MA0140.3 17 bp overlap
GATA2 2 datasets
Motif DE_48h DE_48h-GATA2_MA0036.4 7 bp overlap
Motif DE_72h DE_72h-GATA2_MA0036.4 7 bp overlap
GATA3 1 dataset
ChIP Kelly GSE65664.GATA3.Kelly 163 bp overlap
GATA4 7 datasets
ChIP DE DE-GATA4-1 672 bp overlap
ChIP DE DE-GATA4-2 636 bp overlap
Motif DE_48h DE_48h-GATA4_MA0482.3 8 bp overlap
Motif DE_72h DE_72h-GATA4_MA0482.3 8 bp overlap
ChIP foregut GSE117136.GATA4.foregut 540 bp overlap
ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 400 bp overlap
ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 396 bp overlap
GATA5 2 datasets
Motif DE_48h DE_48h-GATA5_MA0766.3 8 bp overlap
Motif DE_72h DE_72h-GATA5_MA0766.3 8 bp overlap
GATA6 18 datasets
ChIP DE DE-GATA6-1 655 bp overlap
ChIP DE DE-GATA6-2 804 bp overlap
Motif DE_48h DE_48h-GATA6_MA1104.3 8 bp overlap
Motif DE_48h DE_48h-GATA6_MA1104.3 8 bp overlap
Motif DE_72h DE_72h-GATA6_MA1104.3 8 bp overlap
Motif DE_72h DE_72h-GATA6_MA1104.3 8 bp overlap
ChIP DE_D1 S09-DE-d1-GATA6-exp1 513 bp overlap
ChIP DE_D1 S14-DE-d1-GATA6-exp1 481 bp overlap
ChIP DE_D1 S41-DE-d1-GATA6-exp2 418 bp overlap
ChIP DE_D2 S55-DE-d2-GATA6-exp2 603 bp overlap
ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 668 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 512 bp overlap
ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 525 bp overlap
ChIP foregut GSE117136.GATA6.foregut 465 bp overlap
ChIP foregut_KO GSE117136.GATA6.foregut_KO 480 bp overlap
ChIP pancreatic-progenitor GSE117136.GATA6.pancreatic-progenitor 460 bp overlap
ChIP pancreatic-progenitor_KO GSE117136.GATA6.pancreatic-progenitor_KO 489 bp overlap
ChIP pancreatic-progenitor_PP1 GSE104840.GATA6.pancreatic-progenitor_PP1 264 bp overlap
GFI1 1 dataset
Motif DE_72h DE_72h-GFI1_MA0038.3 11 bp overlap
GSC 1 dataset
Motif DE_72h DE_72h-GSC_MA0648.2 6 bp overlap
GSC2 1 dataset
Motif DE_72h DE_72h-GSC2_MA0891.2 6 bp overlap
Gata3 4 datasets
Motif DE_48h DE_48h-Gata3_MA0037.5 8 bp overlap
Motif DE_48h DE_48h-Gata3_MA0037.5 8 bp overlap
Motif DE_72h DE_72h-Gata3_MA0037.5 8 bp overlap
Motif DE_72h DE_72h-Gata3_MA0037.5 8 bp overlap
HAND2 1 dataset
ChIP CLB-Ga GSE90683.HAND2.CLB-Ga 295 bp overlap
HNF1B 1 dataset
ChIP PANC-1_HNF1B-OE GSE119930.HNF1B.PANC-1_HNF1B-OE 108 bp overlap
IKZF2 2 datasets
Motif DE_48h DE_48h-IKZF2_MA2326.1 6 bp overlap
Motif DE_72h DE_72h-IKZF2_MA2326.1 6 bp overlap
Ikzf3 2 datasets
Motif DE_48h DE_48h-Ikzf3_MA1992.2 9 bp overlap
Motif DE_72h DE_72h-Ikzf3_MA1992.2 9 bp overlap
JUN 1 dataset
ChIP DE_D2 S02-DE-d2-JUN-exp1 281 bp overlap
KDM5B 1 dataset
ChIP HCC2157 GSE46055.KDM5B.HCC2157 73 bp overlap
KLF16 1 dataset
Motif DE_72h DE_72h-KLF16_MA0741.1 11 bp overlap
KLF17 1 dataset
Motif DE_60h DE_60h-KLF17_MA1514.2 14 bp overlap
KLF9 1 dataset
Motif DE_72h DE_72h-KLF9_MA1107.3 11 bp overlap
MEIS1 4 datasets
Motif DE_48h DE_48h-MEIS1_MA0498.3 5 bp overlap
Motif DE_48h DE_48h-MEIS1_MA0498.3 5 bp overlap
Motif DE_72h DE_72h-MEIS1_MA0498.3 5 bp overlap
Motif DE_72h DE_72h-MEIS1_MA0498.3 5 bp overlap
MYOD1 2 datasets
ChIP IMR-90_GM GSE128527.MYOD1.IMR-90_GM 260 bp overlap
ChIP rhabdomyosarcoma GSE50413.MYOD1.rhabdomyosarcoma 95 bp overlap
NEUROG2 6 datasets
ChIP MRC-5_NFD_02DPT GSE75910.NEUROG2.MRC-5_NFD_02DPT 253 bp overlap
ChIP MRC-5_NFD_05DPT GSE75910.NEUROG2.MRC-5_NFD_05DPT 357 bp overlap
ChIP MRC-5_NFD_1DPT GSE75910.NEUROG2.MRC-5_NFD_1DPT 401 bp overlap
ChIP MRC-5_N_02DPT GSE75910.NEUROG2.MRC-5_N_02DPT 458 bp overlap
ChIP MRC-5_N_05DPT GSE75910.NEUROG2.MRC-5_N_05DPT 215 bp overlap
ChIP MRC-5_N_1DPT GSE75910.NEUROG2.MRC-5_N_1DPT 442 bp overlap
NKX2-5 1 dataset
ChIP hESC_ab3584 GSE89457.NKX2-5.hESC_ab3584 324 bp overlap
NR2C2 2 datasets
Motif DE_48h DE_48h-NR2C2_MA0504.2 14 bp overlap
Motif DE_60h DE_60h-NR2C2_MA0504.2 14 bp overlap
NR2F1 2 datasets
Motif DE_48h DE_48h-NR2F1_MA1538.1 15 bp overlap
Motif DE_72h DE_72h-NR2F1_MA1538.1 15 bp overlap
NR2F6 2 datasets
Motif DE_48h DE_48h-NR2F6_MA1539.1 15 bp overlap
Motif DE_72h DE_72h-NR2F6_MA1539.1 15 bp overlap
NUTM1 1 dataset
ChIP NMC24335 GSE96775.NUTM1.NMC24335 732 bp overlap
Nanog 1 dataset
Motif DE_72h DE_72h-Nanog_MA2339.1 7 bp overlap
OGG1 1 dataset
ChIP HEK293 GSE89017.OGG1.HEK293 208 bp overlap
OSR2 3 datasets
Motif DE_48h DE_48h-OSR2_MA1646.2 8 bp overlap
Motif DE_60h DE_60h-OSR2_MA1646.2 8 bp overlap
Motif DE_72h DE_72h-OSR2_MA1646.2 8 bp overlap
OTX1 1 dataset
Motif DE_72h DE_72h-OTX1_MA0711.2 6 bp overlap
OTX2 1 dataset
Motif DE_72h DE_72h-OTX2_MA0712.3 7 bp overlap
PATZ1 1 dataset
Motif DE_72h DE_72h-PATZ1_MA1961.2 11 bp overlap
PHF8 1 dataset
ChIP Hep-G2 ENCSR604VAE.PHF8.Hep-G2 112 bp overlap
PITX1 1 dataset
Motif DE_72h DE_72h-PITX1_MA0682.3 6 bp overlap
PITX2 1 dataset
Motif DE_72h DE_72h-PITX2_MA1547.2 8 bp overlap
PITX3 1 dataset
Motif DE_72h DE_72h-PITX3_MA0714.2 6 bp overlap
PRDM10 2 datasets
ChIP Hep-G2 ENCSR289PSX.PRDM10.Hep-G2 195 bp overlap
ChIP K-562 ENCSR120MPG.PRDM10.K-562 204 bp overlap
PRDM9 1 dataset
Motif DE_72h DE_72h-PRDM9_MA1723.2 20 bp overlap
Plagl1 2 datasets
Motif DE_48h DE_48h-Plagl1_MA1615.2 8 bp overlap
Motif DE_60h DE_60h-Plagl1_MA1615.2 8 bp overlap
Prdm5 2 datasets
Motif DE_48h DE_48h-Prdm5_MA1999.2 11 bp overlap
Motif DE_72h DE_72h-Prdm5_MA1999.2 11 bp overlap
RHOXF1 1 dataset
Motif DE_72h DE_72h-RHOXF1_MA0719.2 6 bp overlap
Rarg 3 datasets
Motif DE_48h DE_48h-Rarg_MA0860.1 17 bp overlap
Motif DE_60h DE_60h-Rarg_MA0860.1 17 bp overlap
Motif DE_72h DE_72h-Rarg_MA0860.1 17 bp overlap
SMAD2 1 dataset
ChIP endoderm GSE29422.SMAD2.endoderm 165 bp overlap
SMAD2-3 1 dataset
ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 878 bp overlap
SMAD2_3 2 datasets
ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 567 bp overlap
ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 460 bp overlap
SMAD3 1 dataset
ChIP endoderm GSE29422.SMAD3.endoderm 179 bp overlap
SMAD4 1 dataset
ChIP endoderm GSE29422.SMAD4.endoderm 201 bp overlap
SOX17 1 dataset
ChIP DE_D2 DED2-SOX17_Batch_II 207 bp overlap
SOX17_M 1 dataset
ChIP DE_D2 DED2-SOX17-M_Batch_II 896 bp overlap
SP8 1 dataset
Motif DE_72h DE_72h-SP8_MA0747.2 11 bp overlap
SP9 1 dataset
Motif DE_72h DE_72h-SP9_MA1564.2 10 bp overlap
TBX5 1 dataset
ChIP hiPSC GSE81585.TBX5.hiPSC 233 bp overlap
THAP1 1 dataset
Motif DE_72h DE_72h-THAP1_MA0597.3 8 bp overlap
TRPS1 4 datasets
Motif DE_48h DE_48h-TRPS1_MA1970.2 8 bp overlap
Motif DE_48h DE_48h-TRPS1_MA1970.2 8 bp overlap
Motif DE_72h DE_72h-TRPS1_MA1970.2 8 bp overlap
Motif DE_72h DE_72h-TRPS1_MA1970.2 8 bp overlap
VDR 1 dataset
ChIP kidney-cortex GSE129585.VDR.kidney-cortex 214 bp overlap
Wt1 1 dataset
Motif DE_72h DE_72h-Wt1_MA1627.2 10 bp overlap
ZFX 1 dataset
ChIP HEK293T_FLAG GSE145160.ZFX.HEK293T_FLAG 420 bp overlap
ZFY 2 datasets
ChIP Hep-G2 ENCSR949OEV.ZFY.Hep-G2 165 bp overlap
ChIP HepG2 ENCFF106ELT 441 bp overlap
ZNF24 3 datasets
ChIP K-562 ENCSR099NCH.ZNF24.K-562 364 bp overlap
ChIP K-562 ENCSR695EQB.ZNF24.K-562 372 bp overlap
ChIP K562 ENCFF877JCX 424 bp overlap
ZNF257 1 dataset
Motif DE_72h DE_72h-ZNF257_MA1710.2 10 bp overlap
ZNF281 1 dataset
Motif DE_72h DE_72h-ZNF281_MA1630.3 10 bp overlap
ZNF354C 2 datasets
Motif DE_48h DE_48h-ZNF354C_MA0130.1 6 bp overlap
Motif DE_60h DE_60h-ZNF354C_MA0130.1 6 bp overlap
ZNF530 2 datasets
Motif DE_48h DE_48h-ZNF530_MA1981.2 14 bp overlap
Motif DE_60h DE_60h-ZNF530_MA1981.2 14 bp overlap
ZNF547 1 dataset
Motif DE_72h DE_72h-ZNF547_MA2334.1 13 bp overlap
ZNF669 1 dataset
Motif DE_48h DE_48h-ZNF669_MA1985.1 15 bp overlap
ZNF740 1 dataset
Motif DE_72h DE_72h-ZNF740_MA0753.3 10 bp overlap