Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SLC25A48. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC25A48 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC25A48, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:135,307,347–135,308,154 | 271.5 kb | Distal (>10kb) Multiome | 124 | |
| chr5:135,398,125–135,400,713 | 180.7 kb | Distal (>10kb) Multiome | 973 | |
| chr5:135,465,814–135,467,333 | 112.9 kb | Distal (>10kb) Multiome HiCAR | 341 | |
| chr5:135,478,683–135,479,412 | 100.1 kb | Distal (>10kb) Multiome HiCAR | 177 | |
| chr5:135,488,761–135,489,592 | 90.1 kb | Distal (>10kb) Multiome | 472 | |
| chr5:135,491,551–135,492,281 | 87.3 kb | Distal (>10kb) Multiome | 397 | |
| chr5:135,534,725–135,536,450 | 43.0 kb | Distal (>10kb) Multiome | 424 | |
| chr5:135,570,228–135,570,447 | 8.7 kb | Proximal (<10kb) | 113 | |
| chr5:135,578,670–135,579,411 | 130 bp | At TSS Multiome HiCAR | 193 | |
| chr5:135,828,079–135,828,565 | 6.1 kb | Proximal (<10kb) | 23 | |
| chr5:135,829,971–135,830,373 | 4.3 kb | Proximal (<10kb) | 180 | |
| chr5:135,834,157–135,835,549 | 255.6 kb | Distal (>10kb) Multiome HiCAR | 472 | |
| chr5:135,859,255–135,860,157 | 280.6 kb | Distal (>10kb) Multiome HiCAR | 15 | |
| chr5:135,877,361–135,878,257 | 298.6 kb | Distal (>10kb) Multiome HiCAR | 83 | |
| chr5:135,929,925–135,930,988 | 351.2 kb | Distal (>10kb) Multiome | 487 | |
| chr5:135,978,027–135,978,664 | 399.4 kb | Distal (>10kb) Multiome | 32 | |
| chr5:136,028,641–136,029,690 | 449.9 kb | Distal (>10kb) Multiome | 586 | |
| chr5:136,132,529–136,134,031 | 553.7 kb | Distal (>10kb) Multiome | 958 |
Genomic view of the SLC25A48 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.