chr21:36,096,914–36,097,455

chr21 : 36,096,914 – 36,097,455

541 bp 76 TFs 9 linked genes

This 541 bp open chromatin element is linked to 9 target genes and is bound by 76 transcription factors.

Linked Genes

9 genes

Gene	Expression	Dist. to TSS	Distance	Link type
ENSG00000233393		7.4 kb	Proximal	Proximity
ENSG00000289001		27.1 kb	Distal	Multiome
CBR1		27.1 kb	Distal	Multiome
SETD4		36.6 kb	Distal	Multiome+HiCAR
CBR3		37.9 kb	Distal	Multiome
CBR3-AS1		59.2 kb	Distal	Multiome
DOP1B		59.6 kb	Distal	Multiome
MORC3		223.1 kb	Distal	Multiome
CHAF1B		288.2 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

76 transcription factors

ChIP WA01 ENCSR000BQU.ATF2.WA01 217 bp overlap

Arid3b 1 dataset

Motif DE_24h DE_24h-Arid3b_MA0601.2 7 bp overlap

ChIP WA01_KDM2B_KO GSE104690.BCOR.WA01_KDM2B_KO 390 bp overlap

BRD3 4 datasets

ChIP H-1_DE GSE126661.BRD3.H-1_DE 70 bp overlap

ChIP MV4-11_DMSO GSE120715.BRD3.MV4-11_DMSO 224 bp overlap

ChIP MV4-11_IBET151_50nM GSE120715.BRD3.MV4-11_IBET151_50nM 168 bp overlap

ChIP THP-1_DMSO GSE138084.BRD3.THP-1_DMSO 289 bp overlap

BRD4 2 datasets

ChIP MV4-11_DMSO GSE120715.BRD4.MV4-11_DMSO 152 bp overlap

ChIP THP-1_iBET-BD2 GSE138084.BRD4.THP-1_iBET-BD2 541 bp overlap

ChIP MOLM-14_IBET GSE65138.CDK8.MOLM-14_IBET 170 bp overlap

ChIP WA01 ENCSR000AVA.CHD7.WA01 393 bp overlap

CTBP2 1 dataset

ChIP WA01 ENCSR000EUO.CTBP2.WA01 212 bp overlap

ChIP esophagus_squamous-epithelium ENCSR838RUX.CTCF.esophagus_squamous-epithelium 330 bp overlap

CTNNB1 1 dataset

ChIP hESC_activinA_15h GSE99202.CTNNB1.hESC_activinA_15h 311 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 436 bp overlap

Motif DE_24h DE_24h-Elf5_MA0136.4 8 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 482 bp overlap

ChIP DE DE-FOXA2-2 448 bp overlap

GATA2 1 dataset

Motif DE_24h DE_24h-GATA2_MA0036.4 7 bp overlap

GATA4 3 datasets

ChIP DE DE-GATA4-1 432 bp overlap

ChIP DE DE-GATA4-2 541 bp overlap

Motif DE_24h DE_24h-GATA4_MA0482.3 8 bp overlap

GATA6 10 datasets

ChIP DE DE-GATA6-1 479 bp overlap

ChIP DE DE-GATA6-2 541 bp overlap

Motif DE_24h DE_24h-GATA6_MA1104.3 8 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 541 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 508 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 408 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 490 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 541 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 536 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 437 bp overlap

Gata3 1 dataset

Motif DE_24h DE_24h-Gata3_MA0037.5 8 bp overlap

ChIP K562 ENCFF882TEV 202 bp overlap

HDAC2 1 dataset

ChIP H1 ENCFF939VKA 189 bp overlap

HOXB2::ELK1 1 dataset

Motif DE_24h DE_24h-HOXB2ELK1_MA1957.1 14 bp overlap

ChIP DE_D1 S08-DE-d1-JUN-exp1 476 bp overlap

ChIP DE_D1 S13-DE-d1-JUN-exp1 257 bp overlap

ChIP DE_D1 S40-DE-d1-JUN-exp2 470 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 433 bp overlap

ChIP DE_D2 S54-DE-d2-JUN-exp2 330 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 432 bp overlap

KLF4 2 datasets

ChIP BJ_INDUCED GSE36570.KLF4.BJ_INDUCED 152 bp overlap

ChIP hiPSC GSE56567.KLF4.hiPSC 220 bp overlap

KMT2A 1 dataset

ChIP MV4-11 GSE79899.KMT2A.MV4-11 277 bp overlap

MAF::NFE2 1 dataset

Motif DE_24h DE_24h-MAFNFE2_MA0501.2 11 bp overlap

ChIP WTC11 ENCFF223QFY 391 bp overlap

ChIP hESC_PRIMED GSE69646.MED1.hESC_PRIMED 541 bp overlap

MORC2 1 dataset

ChIP H9 GSE95374.MORC2.H9 233 bp overlap

Mecom 1 dataset

Motif DE_24h DE_24h-Mecom_MA0029.2 11 bp overlap

NANOG 11 datasets

ChIP GM23338 ENCFF065NZG 311 bp overlap

ChIP GM23338 ENCSR061DGF.NANOG.GM23338 359 bp overlap

ChIP H1 ENCFF747ZPQ 241 bp overlap

ChIP HUES-8 GSE109524.NANOG.HUES-8 541 bp overlap

ChIP WA01 ERP004238.NANOG.WA01 475 bp overlap

ChIP WA01 ENCSR000BMT.NANOG.WA01 332 bp overlap

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 502 bp overlap

ChIP WA09 GSE105028.NANOG.WA09 451 bp overlap

ChIP WA09_heat-shock GSE105028.NANOG.WA09_heat-shock 385 bp overlap

ChIP hESC GSE20650.NANOG.hESC 391 bp overlap

ChIP hESC GSE18292.NANOG.hESC 205 bp overlap

NIPBL 4 datasets

ChIP hESC GSE64758.NIPBL.hESC 300 bp overlap

ChIP hESC_WNT3A GSE64758.NIPBL.hESC_WNT3A 299 bp overlap

ChIP hESC_WNT3A_ACTIVIN GSE64758.NIPBL.hESC_WNT3A_ACTIVIN 407 bp overlap

ChIP hESC_activin GSE64758.NIPBL.hESC_activin 305 bp overlap

Nfe2l2 2 datasets

Motif DE_24h DE_24h-Nfe2l2_MA0150.3 11 bp overlap

Motif DE_24h DE_24h-Nfe2l2_MA0150.3 11 bp overlap

Nr2F6 1 dataset

Motif DE_24h DE_24h-Nr2F6_MA0728.1 15 bp overlap

Nr2e1 1 dataset

Motif DE_24h DE_24h-Nr2e1_MA0676.1 9 bp overlap

ChIP K562 ENCFF829SLD 187 bp overlap

POLR2A 1 dataset

ChIP GM23338 ENCFF450WCS 419 bp overlap

POU1F1 1 dataset

Motif DE_24h DE_24h-POU1F1_MA0784.3 14 bp overlap

POU2F1::SOX2 1 dataset

Motif DE_24h DE_24h-POU2F1SOX2_MA1962.1 17 bp overlap

POU2F3 1 dataset

Motif DE_24h DE_24h-POU2F3_MA0627.3 9 bp overlap

POU3F1 1 dataset

Motif DE_24h DE_24h-POU3F1_MA0786.2 10 bp overlap

POU3F2 1 dataset

Motif DE_24h DE_24h-POU3F2_MA0787.1 12 bp overlap

POU3F3 1 dataset

Motif DE_24h DE_24h-POU3F3_MA0788.1 13 bp overlap

POU5F1 9 datasets

ChIP BG03 GSE21614.POU5F1.BG03 153 bp overlap

ChIP DE_D1 DED1-OCT4_Batch_II 500 bp overlap

ChIP GM23338 ENCFF333SNB 311 bp overlap

ChIP HUES-8 GSE109524.POU5F1.HUES-8 458 bp overlap

ChIP hESC ENCSR264RJX.POU5F1.hESC 372 bp overlap

ChIP hESC_NAIVE GSE69646.POU5F1.hESC_NAIVE 358 bp overlap

ChIP hESC_PRIMED GSE69646.POU5F1.hESC_PRIMED 541 bp overlap

ChIP hiPSC GSE56567.POU5F1.hiPSC 302 bp overlap

ChIP hiPSC_3s2 GSE81899.POU5F1.hiPSC_3s2 360 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 265 bp overlap

Pou5f1::Sox2 1 dataset

Motif DE_24h DE_24h-Pou5f1Sox2_MA0142.1 15 bp overlap

Pparg::Rxra 1 dataset

Motif DE_24h DE_24h-PpargRxra_MA0065.3 13 bp overlap

Motif DE_24h DE_24h-RELA_MA0107.1 10 bp overlap

SALL3 1 dataset

ChIP hiPSC GSE104863.SALL3.hiPSC 340 bp overlap

SMAD2 2 datasets

ChIP hESC_YAP-_activinA_15h GSE99202.SMAD2.hESC_YAP-_activinA_15h 541 bp overlap

ChIP hESC_activinA_15h GSE99202.SMAD2.hESC_activinA_15h 530 bp overlap

SMAD2-3 4 datasets

ChIP HUES-8 GSE109524.SMAD2-3.HUES-8 372 bp overlap

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 469 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 541 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 541 bp overlap

SMAD2_3 6 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 541 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 541 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 541 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 541 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 541 bp overlap

ChIP ESC S33-ESC-d0-SMAD2_3-exp2 479 bp overlap

SMAD3 1 dataset

ChIP BG03 GSE21614.SMAD3.BG03 239 bp overlap

SMARCA4 2 datasets

ChIP hiPSC GSE124903.SMARCA4.hiPSC 483 bp overlap

ChIP hiPSC_WT GSE124903.SMARCA4.hiPSC_WT 242 bp overlap

SMARCB1 2 datasets

ChIP hiPSC GSE124903.SMARCB1.hiPSC 452 bp overlap

ChIP hiPSC_WT GSE124903.SMARCB1.hiPSC_WT 235 bp overlap

SMARCC1 4 datasets

ChIP DE_D1 S15-DE-d1-BAF155-exp1 331 bp overlap

ChIP DE_D1 S15-DE-d1-BAF155-exp1 123 bp overlap

ChIP hiPSC GSE124903.SMARCC1.hiPSC 438 bp overlap

ChIP hiPSC_WT GSE124903.SMARCC1.hiPSC_WT 386 bp overlap

SOX10 1 dataset

Motif DE_24h DE_24h-SOX10_MA0442.3 6 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 256 bp overlap

SOX2 2 datasets

ChIP hESC GSE18292.SOX2.hESC 184 bp overlap

ChIP hiPSC GSE56567.SOX2.hiPSC 420 bp overlap

Motif DE_24h DE_24h-SOX4_MA0867.3 8 bp overlap

ChIP H1 ENCFF263FUH 251 bp overlap

ChIP WA01 ENCSR000BIR.SP1.WA01 264 bp overlap

Sox11 1 dataset

Motif DE_24h DE_24h-Sox11_MA0869.3 8 bp overlap

Motif DE_24h DE_24h-Sox6_MA0515.1 10 bp overlap

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 440 bp overlap

ChIP H9_MESODERM GSE60606.T.H9_MESODERM 443 bp overlap

ChIP hESC_2h GSE122298.TBP.hESC_2h 171 bp overlap

ChIP hiPSC_WTb_RNase-pos GSE128135.TBP.hiPSC_WTb_RNase-pos 279 bp overlap

ChIP NPC GSE154479.TCF3.NPC 154 bp overlap

TEAD4 3 datasets

ChIP ESC S26-ESC-d0-TEAD4-exp1 317 bp overlap

ChIP H1 ENCFF778PAX 245 bp overlap

ChIP hESC GSE99202.TEAD4.hESC 390 bp overlap

TFAP2A 1 dataset

ChIP WA09 GSE105081.TFAP2A.WA09 229 bp overlap

TFAP2C 3 datasets

ChIP UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc 304 bp overlap

ChIP UCLA1-hESCs_TFAP2C--_2d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_2d_TFAP2C_Induc 123 bp overlap

ChIP WA09 GSE105081.TFAP2C.WA09 146 bp overlap

TGIF2 1 dataset

ChIP WTC11 ENCFF649SHI 76 bp overlap

TP53 3 datasets

ChIP H9 GSE142050.TP53.H9 469 bp overlap

ChIP H9_ectoderm GSE142050.TP53.H9_ectoderm 359 bp overlap

ChIP hESC_DIFF GSE39912.TP53.hESC_DIFF 304 bp overlap

TP63 2 datasets

ChIP keratinocyte_D0 GSE59824.TP63.keratinocyte_D0 70 bp overlap

ChIP keratinocyte_D2 GSE59824.TP63.keratinocyte_D2 125 bp overlap

TRIM28 1 dataset

ChIP WIBR3_NAIVE GSE84382.TRIM28.WIBR3_NAIVE 396 bp overlap

TRPS1 1 dataset

Motif DE_24h DE_24h-TRPS1_MA1970.2 8 bp overlap

ZBTB17 1 dataset

ChIP HEK293 ENCFF865LIO 51 bp overlap

ZNF512 2 datasets

ChIP K-562 ENCSR591CCL.ZNF512.K-562 283 bp overlap

ChIP K562 ENCFF455WDH 344 bp overlap

ZNF585B 1 dataset

ChIP HEK293 ENCFF657XIZ 275 bp overlap

ZNF700 1 dataset

ChIP K562 ENCFF657OXY 65 bp overlap