CBR1

carbonyl reductase 1 | SDR21C1, CBR

The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]

Member of: DE-1 DE-1.17

Biological processes 29 terms

15-hydroxyprostaglandin dehydrogenase (NADP+) activity (GO:0047021)15-hydroxyprostaglandin dehydrogenase (NADP+) activity (GO:0047021)15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity (GO:0047020)S-nitrosoglutathione reductase (NADPH) activity (GO:0160163)alcohol dehydrogenase (NADP+) activity (GO:0008106)alcohol dehydrogenase [NAD(P)+] activity (GO:0018455)carbonyl reductase (NADPH) activity (GO:0004090)carbonyl reductase (NADPH) activity (GO:0004090)carbonyl reductase (NADPH) activity (GO:0004090)carbonyl reductase (NADPH) activity (GO:0004090)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)epithelial cell differentiation (GO:0030855)extracellular exosome (GO:0070062)extracellular vesicle (GO:1903561)glucocorticoid metabolic process (GO:0008211)oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor (GO:0016655)oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor (GO:0016655)oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (GO:0016616)oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (GO:0016616)positive regulation of reactive oxygen species metabolic process (GO:2000379)prostaglandin E2 9-reductase activity (GO:0050221)prostaglandin E2 9-reductase activity (GO:0050221)prostaglandin E2 9-reductase activity (GO:0050221)prostanoid biosynthetic process (GO:0046457)protein binding (GO:0005515)vitamin K metabolic process (GO:0042373)xenobiotic metabolic process (GO:0006805)

Expression (TPM)

TFs regulating CBR1 0 TFs

Transcription factors with Perturb-seq knockdown data for CBR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CBR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to CBR1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CBR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr21:34,865,900–34,866,326	1203.9 kb	Distal (>10kb) Multiome HiCAR	314
chr21:36,059,813–36,061,105	9.5 kb	Proximal (<10kb) Multiome	865
chr21:36,069,719–36,070,524	11 bp	At TSS Multiome	634
chr21:36,073,934–36,074,218	3.9 kb	Proximal (<10kb)	11
chr21:36,096,914–36,097,455	27.1 kb	Distal (>10kb) Multiome	76
chr21:36,099,712–36,100,295	30.0 kb	Distal (>10kb) Multiome HiCAR	79
chr21:36,104,387–36,104,959	34.8 kb	Distal (>10kb) Multiome	137
chr21:36,155,542–36,157,554	86.6 kb	Distal (>10kb) Multiome	789
chr21:36,319,638–36,321,035	250.2 kb	Distal (>10kb) Multiome	945

Genome Browser

Genomic view of the CBR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.