Transcription factors with Perturb-seq knockdown data for CBR3-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CBR3-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CBR3-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:36,059,813–36,061,105 | 95.8 kb | Distal (>10kb) Multiome | 865 | |
| chr21:36,069,719–36,070,524 | 86.3 kb | Distal (>10kb) Multiome | 634 | |
| chr21:36,096,914–36,097,455 | 59.2 kb | Distal (>10kb) Multiome | 76 | |
| chr21:36,099,712–36,100,295 | 56.3 kb | Distal (>10kb) Multiome | 79 | |
| chr21:36,104,387–36,104,959 | 51.5 kb | Distal (>10kb) Multiome | 137 | |
| chr21:36,155,542–36,157,554 | 251 bp | At TSS Multiome | 789 | |
| chr21:36,319,638–36,321,035 | 163.9 kb | Distal (>10kb) Multiome | 945 | |
| chr21:36,385,010–36,385,875 | 229.1 kb | Distal (>10kb) Multiome | 530 |
Genomic view of the CBR3-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.