Enables histone H4K20 methyltransferase activity. Predicted to be involved in several processes, including positive regulation of inflammatory response; positive regulation of macromolecule biosynthetic process; and regulation of cell proliferation in bone marrow. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SETD4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SETD4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SETD4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:34,745,569–34,746,197 | 1314.8 kb | Distal (>10kb) Multiome HiCAR | 505 | |
| chr21:34,888,547–34,890,899 | 1170.3 kb | Distal (>10kb) Multiome HiCAR | 896 | |
| chr21:36,059,813–36,061,105 | 17 bp | At TSS Multiome | 865 | |
| chr21:36,069,719–36,070,524 | 9.5 kb | Proximal (<10kb) Multiome | 634 | |
| chr21:36,096,914–36,097,455 | 36.6 kb | Distal (>10kb) Multiome HiCAR | 76 | |
| chr21:36,099,712–36,100,295 | 39.5 kb | Distal (>10kb) Multiome HiCAR | 79 | |
| chr21:36,104,387–36,104,959 | 44.2 kb | Distal (>10kb) Multiome | 137 | |
| chr21:36,155,542–36,157,554 | 96.1 kb | Distal (>10kb) Multiome | 789 | |
| chr21:36,319,638–36,321,035 | 259.6 kb | Distal (>10kb) Multiome | 945 |
Genomic view of the SETD4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.