DE-11

Supermodule 267 genes

Cell cycle and mitotic chromosome segregation machinery

This 267-gene module contains BIRC5, MKI67, AURKA, and PLK1, with strong enrichment for mitotic nuclear division, chromosome segregation, and spindle apparatus components. Knockdown of ARID1A activates this module. Knockdown of FOXH1, SMAD4, SMAD3, E2F6, and SNAI1 represses this module.

Key terms: cell cycle mitotic nuclear division mitotic cell cycle nuclear division cell cycle process Notable genes: BIRC5 MKI67 AURKA PLK1 FOXM1 CHEK2 CDK1 IDH2 Top TFs: FOXH1 SMAD4 SMAD3 E2F6 SNAI1

TF Regulatory Network

Direction indicates the effect of TF knockdown on this module (↑ = KD upregulates; ↓ = KD downregulates).

Perturbation + Binding ↑ ↓

Perturbation only ↑ ↓

Binding only

TF	Dir	NES	#gRNA	padj	Bind	OR

Submodules (7)

Finer-grained co-expression clusters within this supermodule, each with a distinct functional signature.

Submodule	Genes	Notable genes
DE-11.1	70	MKI67 AURKA PLK1 CDK1 TOP2A
DE-11.2	25	CHEK2 IDH2 CTCF XRCC5 SLC29A1
DE-11.3	22	FOXM1 CIP2A WEE1 CBX5 PBK
DE-11.4	17	SRSF1 EIF4G1 NONO LIG3 MATR3
DE-11.5	14	BIRC5 PTTG1 CDC20 HMMR DYNLL1
DE-11.6	13	NCL HNRNPA2B1 HNRNPD MARCKS SFPQ
DE-11.7	10	PTBP1 TCOF1 GORASP2 DHX33 SF1

Module Genes

All genes assigned to this co-expression supermodule.

Gene	Type	Submodule	Publications

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).