The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for AURKA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AURKA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AURKA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:54,843,792–54,844,536 | 1548.1 kb | Distal (>10kb) Multiome HiCAR | 141 | |
| chr20:54,849,030–54,850,253 | 1542.5 kb | Distal (>10kb) Multiome HiCAR | 150 | |
| chr20:55,028,728–55,030,077 | 1362.7 kb | Distal (>10kb) Multiome HiCAR | 150 | |
| chr20:56,358,373–56,359,678 | 33.3 kb | Distal (>10kb) Multiome | 612 | |
| chr20:56,391,539–56,393,046 | 217 bp | At TSS Multiome | 1080 | |
| chr20:56,400,135–56,400,293 | 7.9 kb | Proximal (<10kb) | 148 | |
| chr20:56,468,222–56,468,931 | 76.4 kb | Distal (>10kb) Multiome | 887 | |
| chr20:56,624,898–56,625,604 | 232.9 kb | Distal (>10kb) Multiome | 210 | |
| chr20:56,628,380–56,631,136 | 238.2 kb | Distal (>10kb) Multiome | 551 | |
| chr20:56,690,044–56,691,001 | 298.4 kb | Distal (>10kb) Multiome | 191 | |
| chr20:57,002,615–57,003,823 | 611.1 kb | Distal (>10kb) Multiome HiCAR | 200 |
Genomic view of the AURKA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.