This 25-gene module includes CHEK2, IDH2, CTCF, and XRCC5, with enrichment in chromosomal regions, centromeric regions, and condensed chromatin, along with processes of chromosome organization, chromosome segregation, and spindle organization. Knockdown of SNAI1, SMAD3, and MIXL1 represses this module. No TFs that activate this module upon knockdown were identified.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.