This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for LIG3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LIG3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LIG3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:34,742,533–34,742,963 | 237.8 kb | Distal (>10kb) Multiome | 19 | |
| chr17:34,798,552–34,799,335 | 181.6 kb | Distal (>10kb) Multiome | 89 | |
| chr17:34,886,833–34,887,368 | 93.4 kb | Distal (>10kb) Multiome | 205 | |
| chr17:34,961,027–34,961,847 | 19.0 kb | Distal (>10kb) Multiome | 793 | |
| chr17:34,980,134–34,981,317 | 142 bp | At TSS Multiome | 855 | |
| chr17:35,063,589–35,064,217 | 83.3 kb | Distal (>10kb) Multiome | 813 | |
| chr17:35,088,426–35,090,139 | 108.8 kb | Distal (>10kb) Multiome | 805 | |
| chr17:35,119,302–35,120,200 | 139.3 kb | Distal (>10kb) Multiome HiCAR | 761 | |
| chr17:35,141,908–35,142,655 | 161.8 kb | Distal (>10kb) Multiome | 873 | |
| chr17:35,242,191–35,243,858 | 262.4 kb | Distal (>10kb) Multiome | 590 |
Genomic view of the LIG3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.