DE-11 ›

DE-11.3

Submodule 22 genes

Mitotic cell cycle phase transition regulation

This 22-gene module includes FOXM1, CIP2A, WEE1, CBX5, and PBK, with enrichment in mitotic cell cycle phase transition and cell cycle phase transition processes. Knockdown of GRHL2 activates this module. Knockdown of SMAD4, FOXH1, and SMAD3 represses this module.

Key terms: mitotic cell cycle mitotic cell cycle process cell cycle cell cycle process Notable genes: FOXM1 CIP2A WEE1 CBX5 PBK CEP55 STIL KIF15 Top TFs: SMAD4 FOXH1 SMAD3 GATA4 GRHL2

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (22)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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