Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for DYNLL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DYNLL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DYNLL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:120,200,671–120,201,921 | 294.8 kb | Distal (>10kb) Multiome | 1006 | |
| chr12:120,228,170–120,231,900 | 267.5 kb | Distal (>10kb) Multiome | 1050 | |
| chr12:120,265,150–120,266,362 | 230.3 kb | Distal (>10kb) Multiome | 617 | |
| chr12:120,290,301–120,293,526 | 202.9 kb | Distal (>10kb) Multiome | 1338 | |
| chr12:120,302,138–120,302,609 | 193.8 kb | Distal (>10kb) Multiome | 711 | |
| chr12:120,317,215–120,317,997 | 178.5 kb | Distal (>10kb) Multiome | 872 | |
| chr12:120,361,277–120,362,299 | 134.3 kb | Distal (>10kb) Multiome | 308 | |
| chr12:120,368,637–120,370,303 | 126.9 kb | Distal (>10kb) Multiome | 250 | |
| chr12:120,388,762–120,389,560 | 106.9 kb | Distal (>10kb) Multiome | 178 | |
| chr12:120,394,470–120,395,052 | 101.3 kb | Distal (>10kb) Multiome | 283 | |
| chr12:120,413,842–120,414,516 | 81.9 kb | Distal (>10kb) Multiome | 289 | |
| chr12:120,437,436–120,438,568 | 58.1 kb | Distal (>10kb) Multiome | 725 | |
| chr12:120,445,927–120,446,970 | 49.6 kb | Distal (>10kb) Multiome | 982 | |
| chr12:120,468,864–120,470,390 | 26.3 kb | Distal (>10kb) Multiome HiCAR | 942 | |
| chr12:120,495,362–120,496,939 | 94 bp | At TSS Multiome | 794 | |
| chr12:120,528,856–120,529,468 | 33.1 kb | Distal (>10kb) Multiome HiCAR | 849 | |
| chr12:120,534,230–120,535,077 | 38.4 kb | Distal (>10kb) Multiome | 730 | |
| chr12:120,580,919–120,581,830 | 85.3 kb | Distal (>10kb) Multiome | 736 | |
| chr12:120,584,329–120,585,045 | 88.6 kb | Distal (>10kb) Multiome | 460 | |
| chr12:120,640,005–120,641,704 | 144.4 kb | Distal (>10kb) Multiome | 562 | |
| chr12:120,648,914–120,649,665 | 153.2 kb | Distal (>10kb) Multiome | 405 | |
| chr12:120,668,575–120,669,135 | 172.7 kb | Distal (>10kb) Multiome | 98 | |
| chr12:120,686,185–120,687,741 | 190.7 kb | Distal (>10kb) Multiome | 1030 | |
| chr12:120,710,025–120,711,277 | 214.3 kb | Distal (>10kb) Multiome | 573 | |
| chr12:120,725,271–120,726,309 | 229.7 kb | Distal (>10kb) Multiome | 663 |
Genomic view of the DYNLL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.