PLK1

polo like kinase 1 | PLK

The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of this protein in cancer cells dramatically inhibited cell proliferation and induced apoptosis; hence, it is a target for cancer therapy. [provided by RefSeq, Sep 2015]

Member of: DE-11 DE-11.1

Biological processes 96 terms

ATP binding (GO:0005524)ATP binding (GO:0005524)G2/M transition of mitotic cell cycle (GO:0000086)G2/M transition of mitotic cell cycle (GO:0000086)Golgi inheritance (GO:0048313)anaphase-promoting complex binding (GO:0010997)astral microtubule organization (GO:0030953)centriolar satellite (GO:0034451)centriole (GO:0005814)centrosome (GO:0005813)centrosome (GO:0005813)centrosome (GO:0005813)centrosome (GO:0005813)centrosome cycle (GO:0007098)chromatin (GO:0000785)chromosome, centromeric region (GO:0000775)condensed chromosome, centromeric region (GO:0000779)cytoplasm (GO:0005737)cytosol (GO:0005829)double-strand break repair (GO:0006302)double-strand break repair via alternative nonhomologous end joining (GO:0097681)establishment of protein localization (GO:0045184)identical protein binding (GO:0042802)kinetochore (GO:0000776)kinetochore (GO:0000776)kinetochore (GO:0000776)magnesium ion binding (GO:0000287)metaphase/anaphase transition of mitotic cell cycle (GO:0007091)microtubule binding (GO:0008017)microtubule bundle formation (GO:0001578)microtubule cytoskeleton (GO:0015630)midbody (GO:0030496)midbody (GO:0030496)mitotic G2 DNA damage checkpoint signaling (GO:0007095)mitotic cell cycle (GO:0000278)mitotic cell cycle (GO:0000278)mitotic cell cycle (GO:0000278)mitotic chromosome condensation (GO:0007076)mitotic cleavage furrow formation (GO:1903673)mitotic cytokinesis (GO:0000281)mitotic cytokinesis (GO:0000281)mitotic nuclear membrane disassembly (GO:0007077)mitotic sister chromatid segregation (GO:0000070)mitotic sister chromatid segregation (GO:0000070)mitotic spindle assembly checkpoint signaling (GO:0007094)mitotic spindle organization (GO:0007052)mitotic spindle organization (GO:0007052)mitotic spindle pole (GO:0097431)negative regulation of apoptotic process (GO:0043066)negative regulation of double-strand break repair via homologous recombination (GO:2000042)negative regulation of transcription by RNA polymerase II (GO:0000122)nuclear division (GO:0000280)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)outer kinetochore (GO:0000940)positive regulation of mitotic metaphase/anaphase transition (GO:0045842)positive regulation of mitotic nuclear envelope disassembly (GO:1905559)positive regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032436)positive regulation of protein localization to nucleus (GO:1900182)positive regulation of ubiquitin-dependent protein catabolic process (GO:2000060)protein binding (GO:0005515)protein kinase activity (GO:0004672)protein kinase activity (GO:0004672)protein kinase binding (GO:0019901)protein localization to chromatin (GO:0071168)protein phosphorylation (GO:0006468)protein serine kinase activity (GO:0106310)protein serine kinase activity (GO:0106310)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)regulation of anaphase-promoting complex-dependent catabolic process (GO:1905784)regulation of cell cycle (GO:0051726)regulation of cell cycle process (GO:0010564)regulation of cytokinesis (GO:0032465)regulation of cytokinesis (GO:0032465)regulation of mitotic cell cycle (GO:0007346)regulation of mitotic cell cycle phase transition (GO:1901990)regulation of mitotic metaphase/anaphase transition (GO:0030071)regulation of mitotic metaphase/anaphase transition (GO:0030071)regulation of mitotic spindle assembly (GO:1901673)regulation of protein localization to cell cortex (GO:1904776)sister chromatid cohesion (GO:0007062)spindle (GO:0005819)spindle (GO:0005819)spindle microtubule (GO:0005876)spindle midzone (GO:0051233)spindle pole (GO:0000922)spindle pole (GO:0000922)spindle pole (GO:0000922)synaptonemal complex (GO:0000795)

Expression (TPM)

TFs regulating PLK1 0 TFs

Transcription factors with Perturb-seq knockdown data for PLK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to PLK1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr16:23,452,612–23,453,515	225.9 kb	Distal (>10kb) Multiome	1008
chr16:23,509,880–23,510,853	168.4 kb	Distal (>10kb) Multiome	947
chr16:23,557,038–23,558,356	121.3 kb	Distal (>10kb) Multiome	1119
chr16:23,595,873–23,596,693	82.6 kb	Distal (>10kb) Multiome	938
chr16:23,640,088–23,640,480	38.7 kb	Distal (>10kb) Multiome	169
chr16:23,641,019–23,641,779	37.4 kb	Distal (>10kb) Multiome	1055
chr16:23,678,415–23,679,119	101 bp	At TSS Multiome	878
chr16:23,694,678–23,695,256	16.2 kb	Distal (>10kb) Multiome	456
chr16:23,835,511–23,836,674	157.0 kb	Distal (>10kb) Multiome	420

Genome Browser

Genomic view of the PLK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.