The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
Transcription factors with Perturb-seq knockdown data for PTTG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PTTG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PTTG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:160,133,074–160,134,351 | 288.3 kb | Distal (>10kb) Multiome | 270 | |
| chr5:160,159,956–160,160,873 | 261.6 kb | Distal (>10kb) Multiome | 276 | |
| chr5:160,161,037–160,162,516 | 260.0 kb | Distal (>10kb) Multiome | 167 | |
| chr5:160,165,122–160,166,166 | 256.0 kb | Distal (>10kb) Multiome | 537 | |
| chr5:160,188,095–160,189,161 | 233.3 kb | Distal (>10kb) Multiome | 472 | |
| chr5:160,199,034–160,200,016 | 222.3 kb | Distal (>10kb) Multiome | 455 | |
| chr5:160,287,012–160,288,061 | 134.2 kb | Distal (>10kb) Multiome | 461 | |
| chr5:160,311,564–160,313,046 | 109.3 kb | Distal (>10kb) Multiome | 576 | |
| chr5:160,344,991–160,345,682 | 76.4 kb | Distal (>10kb) Multiome | 420 | |
| chr5:160,399,366–160,400,211 | 22.0 kb | Distal (>10kb) Multiome | 808 | |
| chr5:160,416,486–160,416,678 | 5.2 kb | Proximal (<10kb) | 9 | |
| chr5:160,418,768–160,419,557 | 2.7 kb | Proximal (<10kb) Multiome | 703 | |
| chr5:160,421,652–160,422,209 | 3 bp | At TSS Multiome | 576 | |
| chr5:160,423,244–160,423,455 | 1.4 kb | Proximal (<10kb) | 66 | |
| chr5:160,423,607–160,423,772 | 1.8 kb | Proximal (<10kb) | 16 | |
| chr5:160,438,451–160,439,591 | 17.3 kb | Distal (>10kb) Multiome | 556 |
Genomic view of the PTTG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.