DE-11 ›

DE-11.5

Submodule 14 genes

Spindle assembly and mitotic cell cycle progression

This 14-gene module includes BIRC5, PTTG1, CDC20, HMMR, and DYNLL1, with enrichment for spindle structure, mitotic cell cycle phase transition, and cell cycle phase transition. Knockdown of FOXH1, E2F6, and SOX17 represses this module, suggesting these factors normally support its expression during ESC-to-DE differentiation.

Key terms: cell cycle mitotic cell cycle cell cycle process mitotic cell cycle phase transition Notable genes: BIRC5 PTTG1 CDC20 HMMR DYNLL1 KIF20A CDKN3 UBE2S Top TFs: FOXH1 E2F6 SOX17

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (14)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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