This 70-gene module contains highly-published cell cycle regulators including MKI67, AURKA, and PLK1, with strong enrichment for mitotic nuclear division, spindle organization, and microtubule-associated functions. Knockdown of ARID1A activates this module. Knockdown of FOXH1, SMAD3, SMAD4, SIRT6, and FOXA2 represses this module.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.