This module contains 10 genes including PTBP1, TCOF1, GORASP2, DHX33, and SF1, with enriched terms related to RNA processing, nucleolar organization, and ribosomal biogenesis. Knockdown of SOX17 activates this module, while knockdown of FOXA2, EOMESODERMIN, and GSC repress it. The module's repression by multiple endoderm-specifying factors suggests it represents a function suppressed during definitive endoderm differentiation.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.