Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Transcription factors with Perturb-seq knockdown data for IDH2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IDH2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IDH2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:89,893,669–89,894,442 | 208.4 kb | Distal (>10kb) Multiome | 1083 | |
| chr15:89,912,261–89,913,121 | 189.6 kb | Distal (>10kb) Multiome | 514 | |
| chr15:89,999,673–90,000,089 | 102.5 kb | Distal (>10kb) Multiome | 174 | |
| chr15:90,001,237–90,002,666 | 100.7 kb | Distal (>10kb) Multiome | 589 | |
| chr15:90,059,488–90,060,208 | 42.6 kb | Distal (>10kb) Multiome | 439 | |
| chr15:90,061,829–90,062,285 | 40.4 kb | Distal (>10kb) Multiome | 347 | |
| chr15:90,075,459–90,076,479 | 26.5 kb | Distal (>10kb) Multiome | 275 | |
| chr15:90,095,477–90,095,909 | 6.6 kb | Proximal (<10kb) | 384 | |
| chr15:90,101,222–90,101,417 | 1.1 kb | Proximal (<10kb) | 218 | |
| chr15:90,101,730–90,103,001 | 59 bp | At TSS Multiome | 693 | |
| chr15:90,143,210–90,143,683 | 40.9 kb | Distal (>10kb) Multiome | 578 | |
| chr15:90,152,072–90,152,533 | 49.8 kb | Distal (>10kb) Multiome | 92 | |
| chr15:90,157,949–90,158,473 | 55.7 kb | Distal (>10kb) Multiome | 670 | |
| chr15:90,184,585–90,185,456 | 82.6 kb | Distal (>10kb) Multiome | 806 | |
| chr15:90,200,589–90,202,277 | 98.8 kb | Distal (>10kb) Multiome | 649 | |
| chr15:90,233,136–90,234,524 | 131.6 kb | Distal (>10kb) Multiome | 900 | |
| chr15:90,249,345–90,249,851 | 147.0 kb | Distal (>10kb) Multiome | 655 | |
| chr15:90,265,146–90,266,455 | 163.2 kb | Distal (>10kb) Multiome | 956 | |
| chr15:90,293,225–90,293,932 | 191.1 kb | Distal (>10kb) Multiome | 251 | |
| chr15:90,301,063–90,301,545 | 198.9 kb | Distal (>10kb) Multiome | 241 | |
| chr15:90,319,899–90,320,433 | 217.7 kb | Distal (>10kb) Multiome | 503 | |
| chr15:90,351,610–90,352,876 | 249.7 kb | Distal (>10kb) Multiome | 679 | |
| chr15:90,387,660–90,388,880 | 285.7 kb | Distal (>10kb) Multiome | 722 |
Genomic view of the IDH2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.