The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MARCKS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MARCKS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MARCKS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:112,879,611–112,880,686 | 977.3 kb | Distal (>10kb) Multiome HiCAR | 611 | |
| chr6:113,564,351–113,565,381 | 292.5 kb | Distal (>10kb) Multiome | 641 | |
| chr6:113,586,902–113,587,803 | 269.9 kb | Distal (>10kb) Multiome | 171 | |
| chr6:113,776,752–113,777,865 | 80.1 kb | Distal (>10kb) Multiome | 198 | |
| chr6:113,854,564–113,856,446 | 2.3 kb | Proximal (<10kb) Multiome | 538 | |
| chr6:113,856,568–113,860,608 | 90 bp | At TSS Multiome | 1105 | |
| chr6:113,969,821–113,972,040 | 112.8 kb | Distal (>10kb) Multiome | 1107 |
Genomic view of the MARCKS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.