This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Transcription factors with Perturb-seq knockdown data for BIRC5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BIRC5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BIRC5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:77,915,676–77,916,129 | 298.3 kb | Distal (>10kb) Multiome | 105 | |
| chr17:77,935,380–77,936,363 | 278.4 kb | Distal (>10kb) Multiome | 171 | |
| chr17:77,957,585–77,959,667 | 255.7 kb | Distal (>10kb) Multiome | 1117 | |
| chr17:78,127,361–78,129,338 | 85.5 kb | Distal (>10kb) Multiome | 909 | |
| chr17:78,140,136–78,141,130 | 73.7 kb | Distal (>10kb) Multiome | 594 | |
| chr17:78,168,117–78,169,078 | 45.7 kb | Distal (>10kb) Multiome | 738 | |
| chr17:78,186,463–78,187,739 | 27.0 kb | Distal (>10kb) Multiome | 1021 | |
| chr17:78,213,978–78,214,702 | 38 bp | At TSS Multiome | 902 | |
| chr17:78,231,715–78,232,315 | 17.8 kb | Distal (>10kb) Multiome | 147 | |
| chr17:78,250,689–78,251,651 | 36.8 kb | Distal (>10kb) Multiome | 714 | |
| chr17:78,254,178–78,254,892 | 40.3 kb | Distal (>10kb) Multiome | 860 | |
| chr17:78,270,255–78,273,257 | 58.2 kb | Distal (>10kb) Multiome | 667 | |
| chr17:78,278,089–78,278,902 | 64.3 kb | Distal (>10kb) Multiome | 225 | |
| chr17:78,313,762–78,314,579 | 100.0 kb | Distal (>10kb) Multiome | 636 | |
| chr17:78,341,604–78,342,374 | 127.8 kb | Distal (>10kb) Multiome | 423 | |
| chr17:78,351,461–78,352,240 | 137.5 kb | Distal (>10kb) Multiome | 383 | |
| chr17:78,352,598–78,353,774 | 138.8 kb | Distal (>10kb) Multiome | 687 | |
| chr17:78,356,201–78,356,710 | 142.2 kb | Distal (>10kb) Multiome | 319 | |
| chr17:78,358,869–78,361,525 | 146.0 kb | Distal (>10kb) Multiome | 898 | |
| chr17:78,365,478–78,366,101 | 151.6 kb | Distal (>10kb) Multiome | 305 | |
| chr17:78,378,324–78,379,091 | 164.4 kb | Distal (>10kb) Multiome | 921 |
Genomic view of the BIRC5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.