This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for WEE1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WEE1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WEE1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:9,313,980–9,315,407 | 259.0 kb | Distal (>10kb) Multiome | 997 | |
| chr11:9,318,649–9,319,624 | 254.4 kb | Distal (>10kb) Multiome | 258 | |
| chr11:9,363,967–9,364,851 | 209.2 kb | Distal (>10kb) Multiome | 1019 | |
| chr11:9,384,450–9,385,531 | 189.0 kb | Distal (>10kb) Multiome | 939 | |
| chr11:9,460,209–9,461,643 | 112.8 kb | Distal (>10kb) Multiome | 1040 | |
| chr11:9,566,018–9,566,393 | 7.3 kb | Proximal (<10kb) | 685 | |
| chr11:9,568,906–9,569,135 | 4.5 kb | Proximal (<10kb) | 297 | |
| chr11:9,569,354–9,569,528 | 4.1 kb | Proximal (<10kb) | 518 | |
| chr11:9,572,794–9,575,580 | 1.7 kb | Proximal (<10kb) Multiome | 1075 | |
| chr11:9,613,193–9,614,617 | 40.5 kb | Distal (>10kb) Multiome | 997 | |
| chr11:9,626,920–9,627,395 | 53.5 kb | Distal (>10kb) Multiome | 172 | |
| chr11:9,663,540–9,664,862 | 90.4 kb | Distal (>10kb) Multiome | 597 | |
| chr11:9,757,927–9,759,329 | 184.6 kb | Distal (>10kb) Multiome | 865 | |
| chr11:10,750,622–10,751,770 | 1177.5 kb | Distal (>10kb) Multiome HiCAR | 974 |
Genomic view of the WEE1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.