Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for NCL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NCL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NCL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:231,189,962–231,191,188 | 273.8 kb | Distal (>10kb) Multiome | 358 | |
| chr2:231,198,151–231,199,150 | 265.9 kb | Distal (>10kb) Multiome | 760 | |
| chr2:231,297,093–231,297,547 | 167.2 kb | Distal (>10kb) Multiome | 344 | |
| chr2:231,337,851–231,338,311 | 126.5 kb | Distal (>10kb) Multiome | 58 | |
| chr2:231,370,064–231,371,397 | 93.7 kb | Distal (>10kb) Multiome | 214 | |
| chr2:231,375,406–231,377,370 | 88.0 kb | Distal (>10kb) Multiome | 232 | |
| chr2:231,394,766–231,396,655 | 68.9 kb | Distal (>10kb) Multiome | 339 | |
| chr2:231,410,617–231,411,062 | 53.8 kb | Distal (>10kb) Multiome | 150 | |
| chr2:231,411,845–231,413,014 | 52.2 kb | Distal (>10kb) Multiome | 691 | |
| chr2:231,451,992–231,452,672 | 8.1 kb | Proximal (<10kb) | 373 | |
| chr2:231,452,764–231,453,399 | 7.3 kb | Proximal (<10kb) | 267 | |
| chr2:231,463,695–231,465,687 | 71 bp | At TSS Multiome | 1126 | |
| chr2:231,482,645–231,483,215 | 18.4 kb | Distal (>10kb) Multiome | 450 | |
| chr2:231,483,468–231,484,163 | 19.4 kb | Distal (>10kb) Multiome | 197 | |
| chr2:231,514,074–231,514,984 | 50.0 kb | Distal (>10kb) Multiome | 731 | |
| chr2:231,530,197–231,530,963 | 66.0 kb | Distal (>10kb) Multiome | 395 | |
| chr2:231,557,621–231,558,377 | 93.5 kb | Distal (>10kb) Multiome | 215 | |
| chr2:231,601,487–231,602,111 | 137.3 kb | Distal (>10kb) Multiome | 239 | |
| chr2:231,604,056–231,605,408 | 140.3 kb | Distal (>10kb) Multiome | 677 | |
| chr2:231,611,822–231,613,019 | 148.1 kb | Distal (>10kb) Multiome | 673 | |
| chr2:231,613,128–231,615,041 | 149.7 kb | Distal (>10kb) Multiome | 956 | |
| chr2:231,621,037–231,621,485 | 156.9 kb | Distal (>10kb) Multiome | 189 | |
| chr2:231,661,829–231,663,079 | 197.9 kb | Distal (>10kb) Multiome | 645 | |
| chr2:231,666,093–231,667,175 | 202.1 kb | Distal (>10kb) Multiome | 778 | |
| chr2:231,672,732–231,673,910 | 208.9 kb | Distal (>10kb) Multiome | 570 | |
| chr2:231,674,697–231,675,325 | 210.5 kb | Distal (>10kb) Multiome | 455 | |
| chr2:231,679,801–231,681,869 | 216.6 kb | Distal (>10kb) Multiome | 959 | |
| chr2:231,687,250–231,687,863 | 222.9 kb | Distal (>10kb) Multiome | 640 | |
| chr2:231,706,062–231,711,186 | 243.8 kb | Distal (>10kb) Multiome | 1322 | |
| chr2:231,713,567–231,715,698 | 250.8 kb | Distal (>10kb) Multiome | 974 |
Genomic view of the NCL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.