This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SLC29A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC29A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC29A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:43,926,273–43,928,465 | 296.4 kb | Distal (>10kb) Multiome | 1000 | |
| chr6:43,951,107–43,951,921 | 272.2 kb | Distal (>10kb) Multiome | 591 | |
| chr6:44,002,061–44,003,708 | 220.9 kb | Distal (>10kb) Multiome | 581 | |
| chr6:44,126,767–44,128,943 | 96.1 kb | Distal (>10kb) Multiome | 845 | |
| chr6:44,151,741–44,152,312 | 71.6 kb | Distal (>10kb) Multiome | 575 | |
| chr6:44,185,920–44,186,571 | 37.3 kb | Distal (>10kb) Multiome | 95 | |
| chr6:44,202,490–44,203,242 | 20.7 kb | Distal (>10kb) Multiome | 229 | |
| chr6:44,216,763–44,217,285 | 6.6 kb | Proximal (<10kb) Multiome | 139 | |
| chr6:44,217,417–44,217,710 | 5.9 kb | Proximal (<10kb) | 236 | |
| chr6:44,218,945–44,220,120 | 4.0 kb | Proximal (<10kb) Multiome | 799 | |
| chr6:44,221,398–44,222,005 | 1.6 kb | Proximal (<10kb) | 538 | |
| chr6:44,223,166–44,224,465 | 82 bp | At TSS Multiome | 783 | |
| chr6:44,225,806–44,226,064 | 2.2 kb | Proximal (<10kb) | 294 | |
| chr6:44,234,203–44,235,350 | 11.2 kb | Distal (>10kb) Multiome | 499 | |
| chr6:44,237,380–44,238,386 | 14.3 kb | Distal (>10kb) Multiome | 969 | |
| chr6:44,245,610–44,248,192 | 24.4 kb | Distal (>10kb) Multiome | 1271 | |
| chr6:44,256,209–44,258,064 | 33.8 kb | Distal (>10kb) Multiome | 1042 | |
| chr6:44,264,892–44,265,788 | 41.9 kb | Distal (>10kb) Multiome | 760 | |
| chr6:44,270,373–44,271,349 | 47.4 kb | Distal (>10kb) Multiome | 166 | |
| chr6:44,275,626–44,276,572 | 52.4 kb | Distal (>10kb) Multiome | 330 | |
| chr6:44,297,234–44,298,035 | 74.1 kb | Distal (>10kb) Multiome | 356 | |
| chr6:44,312,866–44,313,523 | 89.7 kb | Distal (>10kb) Multiome | 1073 | |
| chr6:44,342,481–44,342,962 | 119.1 kb | Distal (>10kb) Multiome | 133 | |
| chr6:44,387,185–44,388,395 | 164.1 kb | Distal (>10kb) Multiome | 955 | |
| chr6:44,469,799–44,470,296 | 246.4 kb | Distal (>10kb) Multiome | 375 | |
| chr6:44,475,548–44,476,402 | 252.3 kb | Distal (>10kb) Multiome | 587 |
Genomic view of the SLC29A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.